Cnidoscolus aconitifolius(Mill.) I. M. Johnst leaf extract prevents oxidative hepatic injury and improves muscle glucose uptake ex vivo

Abstract

Total phenol, total flavonoid, and ameliorative potentials of aqueous leaf extract of Cnidoscolus aconitifolius in Fe2+‐induced oxidative stress in hepatic tissue and muscle glucose uptake using ex vivo models were assessed. These were carried out using standard procedures. The results revealed that the extract showed the presence of total phenol and total flavonoid, as well as free radicals scavenging abilities in a dose‐dependent manner. Also, the aqueous leaf extract of C. aconitifolius enhanced Fe2+‐induced oxidative injury in hepatic tissue by considerably reducing the concentration of lipid peroxidation, with improvement in the activities of catalase and superoxide dismutase in a dose‐dependent manner. In addition, the extract enhanced glucose uptake in psoas muscle. It can be deduced from this study that the extract might be beneficial to people with diabetes mellitus. Practical applications Aqueous leaf extract of Cnidoscolus aconitifolius displayed the presence of total phenol and total flavonoid, as well as an increase in free radical scavenging activities in a dose‐dependent manner. The plant extract also improved Fe2+‐induced oxidative injury in hepatic tissue by decreasing lipid peroxidation concentration, improved the activities of catalase as well as superoxide dismutase, with enhancement in glucose uptake of psoas muscle in a dose‐dependent manner.

Bioactive compounds of African star apple (Chrysophyllum albidumG. Don) and its modulatory effect on metabolic activities linked to type 2 diabetes in isolated rat psoas muscle

“…The dose‐dependent increased glucose uptake in isolated muscle tissues incubated with C. albidum infusion (Figure 3) further indicates an antidiabetic effect of the infusion. This corroborates previous reports on the ability of plant extracts and fractions to stimulate muscle glucose uptake (Ajiboye et al., 2019; Erukainure, Chukwuma, et al., 2019; Sanni et al., 2018).…”

Macro- and Micronutrients from Traditional Food Plants Could Improve Nutrition and Reduce Non-Communicable Diseases of Islanders on Atolls in the South Pacific

“…Especially important, given the high NCD (particularly diabetes) rates in the Pacific and northern Australia, are the anti-diabetes and anti-cardiovascular disease effects of most of the plants featured in the factsheets, demonstrated in scientific studies. Studies with evidence for this include the following: drumstick [ 36 , 37 , 38 , 50 , 60 ], amaranth [ 61 , 62 , 63 ], bele [ 64 , 65 , 66 ], chilli [ 67 , 68 , 69 ], purslane [ 70 , 71 , 72 ], kangkong [ 73 , 74 , 75 ], ofenga [ 76 , 77 , 78 ], hedge panax [ 79 , 80 ], chaya [ 39 , 40 ], pumpkin [ 81 , 82 ], and choko [ 83 , 84 ]. Their inclusion in the diet in sufficient quantity is likely to reduce the risk of diabetes and cardiovascular disease, not only by reducing glycemic load when they are included with high-carbohydrate meals, but also because of specific anti-diabetes effects.…”

“…Others, notably lutein (which is usually abundant in leafy vegetables) and zeaxanthin are important for eye health and can reduce the risk of cataracts [35]. Importantly, given the current NCD pandemic, there is growing evidence for specific activity of certain plants against diabetes and cardiovascular disease, e.g., drumstick [36][37][38] and chaya [39,40].…”

Hematoprotective and Gastroprotective Effects of Cnidoscolus aconitifolius (Linn)-Supplemented Diet in Male Wistar Rats

“…Cnidoscolus aconitifolius supplemented diet ameliorates MDA activity at 8 th weeks of feeding. Study on C. aconitifolius reveal the ameliorative potential on MDA activity (index of lipid peroxidation) [42,43]. Similarly, the activity of saponins present in the leaf may be responsible for the potential reduction of lipid peroxidation activity as saponins have been seen to exhibit antioxidant activity by reducing the lipid hydroperoxides level [44].…”

“…The increase in Catalase activity in Cnidoscolus aconitifoliussupplemented diet may be attributed to free radical scavenging activities of Cnidoscolus aconitifolius leaf. These antioxidant properties of the leaf can be attributed to the presence of flavonoids and vitamins C and E in the plant known to possess antioxidant activities [49,50,43,35].…”