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This study aimed to determine antiradical (DPPH• and •OH) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified using HPLC/MS-MS. Its water extract exhibited the highest antiradical activity against •OH (3.21 μg/mL), among the rest due to the presence of gallic, p-coumaric and caffeic acids. At the concentration of 100 μg/mL, the same extract displayed a profound AChE inhibitory activity (60.53%) in liquid, compared to donepezil (89.05%), a drug in clinical practice used as positive control. The flavonoids baicalein and quercetin may be responsible compounds for the AChE inhibitory activity observed. These findings have demonstrated considerable potential of T. versicolor water extract as a natural source of antioxidant(s) and/or AChE inhibitor(s) to be eventually used as drug-like compounds or food supplements in the treatment of Alzheimer’s disease.

Summary The aim of this work was to analyse mineral composition and chemical profile of two nonedible fungal species: Ganoderma lucidum and Ganoderma applanatum (Fruška Gora, Serbia) vs. their antioxidant (ABTS and A.E.A.C. assay) and cytotoxic biopotentials (MTT assay on MCF‐7). Both species were analysed for their content of macro‐ and microelements by atomic absorption spectrophotometry, while phenolic profile of EtOH and H2O extracts was examined by LC‐MS/MS technique. Both species mostly contained the following ions: K+ > Ca2+ > Mg2+ > Mn2+ > Zn2+ > Cu2+ > Cr3+. Among nine phenolic compounds, the highest content of vanillic acid was detected in G. applanatum extracts while protocatechuic acid in EtOH extract and quinic acid in H2O extract were mostly contained in G. lucidum. Ganoderma applanatum EtOH extract showed the best antioxidant activities related to its phenolic and flavonoid content. Further, the best cytotoxic effect after 72 h was observed in this extract as well.

ARTICLE This journal isMetoprolol (MET) belongs to a group of frequently used β 1 -blockers, which often occur in waste waters. The objective of this work was to employ liquid chromatography (LC) and total organic carbon methods to study the photocatalytic degradation of MET in UV irradiated aqueous suspensions of TiO 2 (Wackherr's "Oxyde de titane standard" and Degussa P25), in the presence of different electron acceptors such as molecular oxygen, hydrogen peroxide, potassium bromate, and ammonium persulfate. The degradation rates were found to be strongly influenced by the kind of electron acceptor and the type of catalyst. The optimal amount of hydrogen peroxide and potassium bromate was investigated as well. MET photocatalytic degradation was fastest in the presence of O 2 and potassium bromate with TiO 2 Degussa P25, while mineralization was most efficient in the presence of molecular oxygen alone. In all investigated cases, degradation followed a pseudo-first order kinetics. Reaction intermediates of MET degradation in the presence of different electron acceptors with both catalysts were studied in detail and a number of them were indentified using LC-ESI-MS/MS. The interactions with MET of reactive radical species relevant to this study ( − • 2 O , • OH, • 2 BrO , and − • 4 SO ) were theoretically investigated by means of density functional theory (DFT) computations. § Electronic supplementary information (ESI) available: Influence of electron acceptors on the kinetics of metoprolol photocatalytic degradation in TiO2 suspension. A combined experimental and theoretical study.− 2 8 2 O S , and − 3BrO , can act as electron acceptors to enhance the photodegradation efficiency. These electron acceptors can have several effects including: (I) avoidance of e − −h + recombination because of scavenging of conduction-band electrons; (II) increase of the concentration of • OH and (III) production of other oxidizing species that can enhance the oxidation rate of the substrate and of its intermediate compounds. 10

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