The lack of histological changes of CDMA cellular phone‐based radio frequency on rat testis

Lee, Hae June; Pack, Jeong‐Ki; Kim, Tae Hong; Kim, Nam; Choi, Sujin; Lee, Jae Seon; Kim, Sung Hoon; Lee, Yun Sil

doi:10.1002/bem.20589

Cited by 52 publications

(42 citation statements)

References 27 publications

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“…PARP, p53, bcl-2, caspase 3 and p21 immunoblotting of the testes in RF-EMR exposed and unexposed animals were also evaluated. RF-EMR did not have any observable adverse effects on rat spermatogenesis in this study [15].…”

Section: Studies In Malesmentioning

confidence: 43%

“…This suggests that the impairment of fertility reported in some studies may not be caused by the induction of apoptosis in spermatozoa. The histological changes by RF-EMR fields on rat testis, specifically with respect to sensitive processes such as spermatogenesis, have been also evaluated [15]. Male rats were exposed to RF-EMR for 12 weeks (two 45-min exposure periods, separated by a 15-min interval).…”

Section: Studies In Malesmentioning

confidence: 99%

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Challenging cell phone impact on reproduction: A Review

Merhi

2012

J Assist Reprod Genet

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Purpose The radiofrequency electromagnetic radiation (RF-EMR) produced by cell phones can enhance the excitability of the brain and has recently been classified as carcinogenic. The suggested use of hands-free kits lowers the exposure to the brain, but it might theoretically increase exposure to the reproductive organs. This report summarizes the potential effects of RF-EMR on reproductive potentials in both males and females. Methods A critical review of the literature pertaining to the impact of cell phone RF-EMR on reproduction in male and female animals and humans was performed, with a focus on gonad metabolism, apoptosis of reproductive cells, fertility status, and serum reproductive hormones. Results While some animal and human studies revealed alterations in reproductive physiology in both males and females, others did not report any association. The in vitro and in vivo studies to date are highly diverse, very inconsistent in conduct and, in many cases, report different primary outcomes. Conclusion The increasing use of cell phone warrants welldesigned studies to ascertain the effect of their RF-EMR on reproduction.

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Section: Studies In Malesmentioning

confidence: 43%

Section: Studies In Malesmentioning

confidence: 99%

Challenging cell phone impact on reproduction: A Review

Merhi

2012

J Assist Reprod Genet

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“…Similarly animal studies failed also to provide any consistent evidence for the cancer promoting effects of RF radiation (Gurbuz et al, 2010;Kowalczuk et al, 2010;Lee et al, 2010). Epidemiological studies also failed to clearly and consistently prove an excess cancer or tumor risk (in terms of odds ratios) for cell phone users.…”

Section: Mobile Phone Penetrationmentioning

confidence: 99%

“…Brain tumour risk, 2010). None of these studies could confirm a change in human cells than can be satisfactorily associated with malignant transformation, but some changes in neuronal activity of unknown clinical significance or biological implication were demonstrated (Aalto et al, 2006;Vecchio et al, 2007;Gerner et al, 2010;Lee et al, 2010). The case control human studies, some of which were flawed by to methodological issues (Han et al, 2009;Schüz, 2009;Vrijheid et al, 2009aVrijheid et al, : 2009bAydin et al, 2011;Cardis, 2011) were for the most part inconclusive with some showing even a reduced risk for tumor formation in cell phone users (or "protective effect" in epidemiological terms) rather than an elevated risk (Ahlbom et al, 2009;Saracci and Samet, 2010;The Interphone Study Group Brain tumour risk, 2010;Frei et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Changes in Brain Glioma Incidence and Laterality Correlates with Use of Mobile Phones - a Nationwide Population Based Study in Israel

Barchana

Margaliot²,

Liphshitz³

2012

Asian Pacific Journal of Cancer Prevention

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Introduction: Mobile phones are in extensive use worldwide and concerns regarding their role in tumor formation were raised. Over the years multiple studies were published in order to investigate this issue using several approaches. The current study looks at secular trends of brain gliomas (low and high grade) incidence and changes in tumor's laterality over 30 years in a population extensively using this technology with a possible correlation to the spread of use of mobile phones. Materials and Methods: All brain gliomas that were diagnosed from 1980-2009 were included and subdivided into two groups -low and high grade. Secular and periodic time trend analyses of incidence rates and changes in laterality were performed. Preferred side of head using mobile phones was assessed with a questionnaire in a sample of adult individuals. Results: A decrease in incidence of low grade giomas (LGG) that correlated with introduction of mobile technology was found from 2.57, 2. LGG's over 30-years period that correlates with introducing of mobile phones technology and a shift in laterality towards left-sided tumors, the latter occurred in both low and high-grade gliomas.

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“…Cep telefonlarının yaydığı radyofrekans dalgalarının hücresel ve moleküler düzeyde birçok zararlı etkiye neden olabileceği düşünülmektedir [2]. Elektromanyetik alanın farklı canlılarda üreme sistemine olası yan etkilerinin incelendiği çalışmalarda farklı görüşler bildirilmektedir [3][4][5][6]. Ancak tatmin edici bir mekanizma henüz ortaya konulmamıştır [1].…”

Section: Introductionunclassified

Cep Telefonu Radyasyonunda Melatonin’in Testis Dokusunda Olası Koruyucu Etkisi

Altindag¹,

Kaplanoğlu²,

Aral³

et al. 2017

Dicle Tıp Dergisi

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ÖzetAmaç: Çalışmamızda cep telefonu radyasyonuna kronik etkin kalmanın testis dokusu üzerinde meydana getireceği değişimler ve melatonin kullanımının olası koruyucu etkisinin ışık mikroskobik düzeyde incelenmesi amaçlandı. Yöntemler: 24 adet Wistar albino cinsi erkek sıçan 4 gruba ayrılarak 90 günlük deney süresince; kontrol grubuna hiçbir uygulama yapılmazken, 2. gruba her gün 30 dk 2100 MHz radyasyon uygulaması, 3. gruba her gün derialtı melatonin uygulaması, 4. gruba ise radyasyon uygulamasından 40 dk önce derialtı melatonin ve sonrasında 30 dk radyasyon uygulaması yapıldı. Deney bitiminde yüksek doz anestezi altında feda edilen deneklerden testis dokuları alındı, ağırlıkları ölçülerek ışık mikroskobik izleme yöntemlerinden geçirildi. Örneklere yapısal değişimleri incelemek amacıyla Hematoksilen Eozin, bazal membran kalınlığının değerlendirilmesi amacıyla da PAS boyamaları yapıldı; germinal epitel kalınlığı ve seminifer tübül çapı ile bazal membran kalınlığı ölçülerek istatistiksel analizler yapıldı. Bulgular: Radyasyon uygulaması ile birlikte seminifer tübüllerde düzenli yapının bozulduğu ve seminifer epitel hücreleri arasında ödem oluştuğu izlendi. Radyasyon ve melatonin uygulanan grupta seminifer tübül yapısının radyasyon grubuna karşı oldukça korunduğu dikkati çekti. Tüm gruplarda testis ağırlığında istatistiksel olarak anlamlı bir farklılık saptanmazken, radyasyon uygulanan grupta bazal membranın daha kalın olduğu, germinal epitel kalınlığının azaldığı, seminifer tübül çapının ise arttığı istatistiksel olarak belirlendi. Sonuç: Sonuç olarak yüksek doz cep telefonu radyasyonunun testis histolojik yapısına, özellikle spermatogenezis ve spermiyogenezis düzeyinde etkili olduğu belirlenirken, melatoninin koruyucu özellik gösterdiği kanısına varıldı.

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The lack of histological changes of CDMA cellular phone‐based radio frequency on rat testis

Cited by 52 publications

References 27 publications

Challenging cell phone impact on reproduction: A Review

Challenging cell phone impact on reproduction: A Review

Changes in Brain Glioma Incidence and Laterality Correlates with Use of Mobile Phones - a Nationwide Population Based Study in Israel

Cep Telefonu Radyasyonunda Melatonin’in Testis Dokusunda Olası Koruyucu Etkisi

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