Cep Telefonu Radyasyonunda Melatonin’in Testis Dokusunda Olası Koruyucu Etkisi

Altindag, Ozlem; Kaplanoğlu, Gülnur Take; Aral, Bahriye Sirav; Seymen, Cemile Merve

doi:10.5798/dicletip.298610

Cited by 2 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Melatonin is lipophilic, so it can reach almost all organelles of the cell and especially the cell nucleus. With this feature, it can be said that it has a protective effect against DNA damage (23).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Melatonin on the Bladder in the Application of Low and High Dose Rate Radiotherapy in the Abdominopelvic Region in Rats

Sapmaz¹,

Topkaraoglu²,

Başol³

et al. 2023

hamidiyemedj

View full text Add to dashboard Cite

Background: To compare the changes caused by low and high dose rate radiotherapy in the bladder tissue of rats and to examine the effect of melatonin on the bladder tissue.Materials and Methods: 40 adult rats were randomly divided into five groups with 8 rats in each group. Radiotherapy and melatonin treatment were not applied to group 1 (G1) control group rats. A single dose of 8 Gy and 400 MU/min radiotherapy was applied to G2 and G3 group rats. A single dose of 8 Gy and 1400 MU/min radiotherapy was applied to G4 and G5 group rats. G3 and G5 group (treated groups) rats were given 50 mg/kg melatonin intraperitoneally 15 minutes before the radiotherapy application. Rats were sacrificed under anesthesia and bladder tissues were removed. Histopathological examination was performed on the samples stained with hematoxylin eosin and toluidine blue.Results: Number of mast cells was increased in G2 and G4 (p<0.01). In addition, edema and vascular congestion were observed in these groups. In G3 and G5, acute phase markers decreased compared to radiotherapy received groups. Conclusion:Bladder tissue degradation was observed in G2 and G4 compared to the control group. However, there was no difference in bladder tissue between the groups given two different doses. The acute phase markers of edema, number of mast cells, inflammatory cell infiltration, and vascular congestion in the bladder tissue of the groups administered melatonin decreased.

show abstract

Section: Discussionmentioning

confidence: 99%

The Effects of Melatonin on the Bladder in the Application of Low and High Dose Rate Radiotherapy in the Abdominopelvic Region in Rats

Sapmaz¹,

Topkaraoglu²,

Başol³

et al. 2023

hamidiyemedj

View full text Add to dashboard Cite

show abstract

“…In their study published in 2005, Hata et al hypothesized that low RF radiation may reduce melatonin synthesis in the pineal gland [6] therefore, the use of melatonin as an antioxidant treatment in RF exposure may be an important key point. The chief secretory product of the pineal gland, melatonin (N-acetyl-5-methoxytryptamine) in RF exposure has been studied in several experimental studies including brain, kidney, heart, eye and as well as in many organs [1,7].…”

Section: Introductionmentioning

confidence: 99%

2600 MHz Radiofrequency Radiation Exposure and Protective Role of Melatonin: Effects on Epididymis

Seymen

Oruç

et al. 2021

EUROPEAN J MED ED TE

Self Cite

View full text Add to dashboard Cite

Objective: In this study, our aim is to investigate the possible protective effects of melatonin on potential damage caused by 2600 MHz radiofrequency (RF) radiation exposure on epididymis.Materials and Methods: 36 Wistar Albino male rats were divided into six groups. Group 1: Control, Group 2: Sham Control (mirror of RF exposure), Group 3: Sham Melatonin (mirror of RF exposure and melatonin injection), Group 4: Melatonin (melatonin injection), Group 5: RF (2600 MHz RF exposure), Group 6: RF and Melatonin (2600 MHz RF exposure and melatonin injection). During the experiment, body weights were measured and at the end of the 30-day experimental period, epididymis tissues were collected and examined with Hematoxylin-Eosin.Results: Epididymis was distinguished in normal histological appearance in the Control, Sham Control, Sham Melatonin and Melatonin groups. In the RF group, some structural degenerations were observed such as irregular tubule profile, deterioration and vacuolization in epithelium, loss of stereocilia, seperation in lateral and basal junctions of epithelium and immature sperm formation. In the RF and Melatonin group, the general histological appearance was found to be similar to the control groups except for some continuing degenerations. Conclusion:Taken together, 2600 MHz RF radiation exposure caused some structural degenerations on epididymis and melatonin administration provided therapeutic effects on these degenerations.

show abstract

Cep Telefonu Radyasyonunda Melatonin’in Testis Dokusunda Olası Koruyucu Etkisi

Cited by 2 publications

References 18 publications

The Effects of Melatonin on the Bladder in the Application of Low and High Dose Rate Radiotherapy in the Abdominopelvic Region in Rats

The Effects of Melatonin on the Bladder in the Application of Low and High Dose Rate Radiotherapy in the Abdominopelvic Region in Rats

2600 MHz Radiofrequency Radiation Exposure and Protective Role of Melatonin: Effects on Epididymis

Contact Info

Product

Resources

About