The Influence of the Lead Intoxication of Male Albino Rats on the Functioning of the Nervous System of Their Offspring

Соседова, Л. М.; Kapustina, E. A.; Vokina, Vera A.

doi:10.18821/0016-9900-2018-97-10-972-975

Cited by 4 publications

(1 citation statement)

References 9 publications

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“…The detailed mechanism of how lead induces male infertility has been reviewed [ 15 ], including mitochondrial dysfunction with decreased energy production and impaired cellular processes caused by lead acetate exposure [ 43 ].The problems with the reproductivity of females due to lead exposure are more severe than in males. Lead exposure affects female reproduction by impairing menstruations, such as amenorrhea, dysmenorrhea, and menorrhagia, reducing fertility potential, delaying conception time, altering the hormonal production and circulation, and affecting pregnancy and its outcome [ 44 , 45 ]. There may also be a period of sterility, and if pregnancy does occur, the chances of miscarriage and stillbirth are very high.…”

Section: Discussionmentioning

confidence: 99%

Lead Exposure Assessment and Its Impact on the Structural Organization and Morphological Peculiarities of Rat Ovaries

Osowski,

Fedoniuk,

Bilyk

et al. 2023

Toxics

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Lead is known to be highly toxic to humans, causing various disorders infetal development. An experiment was conducted to examine the effects of lead acetate on the structural organization of female rat ovaries. The study involved 40 non-linear female rats divided into four groups: a control group, a low-dose group, a moderate-dose group, and a high-dose group. The rats were given lead acetate solutions in varying doses for 30 days, and their ovarian tissue was examined using light microscopy.The results showed that increasing doses of lead acetate led to morphological changes in the cortex and medulla of the rat ovaries. The changes were characterized by a decrease in ovarian mass, alterations in the thickness of the tunica albuginea (protein envelope), and a reduction in the number of follicles. Light microscopy revealed that exposure to lead acetate resulted in a significant decrease in the number of follicles in all experimental groups, with the high-dose group experiencing the most significant decrease.These findings suggest that lead acetate has a dose-dependent negative impact on the morphology and function of female rat ovaries. Further studies are needed to investigate the potential impact of lead on human ovarian tissue.

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Section: Discussionmentioning

confidence: 99%

Lead Exposure Assessment and Its Impact on the Structural Organization and Morphological Peculiarities of Rat Ovaries

Osowski,

Fedoniuk,

Bilyk

et al. 2023

Toxics

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Results of fundamental studies of the East Siberian Institute of medical and environmental studies on the main problems of occupational health and human ecology (to the 60th anniversary of the Institute)

Рукавишников

Лахман

Shayakhmetov

et al. 2019

Myditsina truda I promyshlennaya ekologiy

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The solution of modern problems of occupational health and human ecology not only gives the possibility of implementating measures aimed at improving the health of workers, but also determines the future quality of life of the population. Implementation of basic research focused on the study of the pathogenesis of leading occupational and environmentally related diseases, and the development of scientific and practical measures to improve methods of diagnosis, treatment and prevention remain the main activities of the Institute and meet the priorities of the strategy of scientific and technological development of the country and the key objectives of Decree of the President of the Russian Federation from May 7, 2018.The results of long-term studies of the Institute on the infl uence of a number of toxicants (mercury, lead, vinyl chloride and a complex of toxic neurotropic substances formed in fi res) allowed for the fi rst time to develop scientifi c and methodological bases for modeling toxic encephalopathy. Th e features of the formation of violations of bioelectric activity of the brain, revealed violations of metabolic and myogenic mechanisms of regulation of cerebral blood fl ow and elastic-tonic properties of arteries. Studies have allowed to develop a classifi cation of intoxication complex neurotropic toxic substances, methods of predicting their development. Presents a study of possibility of formation in persons with chronic mercury intoxication as an independent professional disease — ophthalmoergonomics. Proved the concept of autoimmunological progressive course occupational toxic encephalopathy. For the fi rst time it was established that silver nanoparticles encapsulated in a natural polymer matrix — arabinogalactan — can penetrate the blood-brain barrier and persist for a long time in the nervous tissue, causing progressive morphological and functional disorders of its cellular and intracellular organization. Th e necessity to develop new methodological approaches to the assessment of safety. An experimental model for the evaluation of neurotoxic properties of nanocomposites has been developed.When studying the eff ect of vibration on the body, it was found that in patients with vibration disease in the post-contact period (aft er the termination of work with a vibration tool), previously formed foci of pathological activity and changes in bioelectric activity with interhemispheric asymmetry persist for a long time. Th e General regularities of changes in the Central aff erent conductive structures and peripheral nerves caused by neurochemical shift s in certain specialized structures of the nervous tissue were establis hed. Th e article presents materials on the impact of industrial emissions on the morbidity of children. When studying the response of the adaptive reactions of the organism to the immune chronic exposure revealed the gradual changes in the indices of immunity.

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Effects of Dihydroquercetin on Behavior of Albino Rat Offspring with Transgenerational Chemical Body Burden

Kapustina¹,

Лисецкая²

2020

PH&LE

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Introduction. Lead pollution is a common environmental problem. Having no physiological functions, this toxicant has a negative polytropic impact on a body, including neurotoxic, reproductive, and transgenerational effects. The mechanism of lead toxicity is oxidative stress. Flavonoids have active antioxidant properties. They are widely represented in plant foods, are able to restore protective capabilities of cells and have chelating properties with respect to lead. One of the representatives of this group of substances is dihydroquercetin. The objective was to study the effect of dihydroquercetin on behavior of rats with hereditary chemical body burden exposed to lead at 60 mg/kg during 25 days. Materials and methods. We studied the behavior of rat offspring in an open field and established their blood lead levels by electrothermal atomization atomic absorption spectrometry. For statistical processing the U-Mann – Whitney test was used. Results. In the present experiment, the effect of lead on the offspring of male albino rats exposed to 60 mg/kg of lead for 25 days caused changes in the activity of animals in the open field. The severity of changes was more pronounced in animals with a hereditary chemical body burden. These animals showed a decrease in orientation and physical activity and increased anxiety. In rats with a hereditary burden, changes in behavior were detected when administering dihydroquercetin. The activity of animals demonstrated a positive dynamics: we observed a statistically significant increase in physical activity and orientation. The number and duration of behavioral acts approached control values. Conclusions. The revealed effects of lead on the offspring of albino rats with a transgenerational chemical body burden require further study to understand the mechanism of the phenomenon.

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The Influence of the Lead Intoxication of Male Albino Rats on the Functioning of the Nervous System of Their Offspring

Cited by 4 publications

References 9 publications

Lead Exposure Assessment and Its Impact on the Structural Organization and Morphological Peculiarities of Rat Ovaries

Lead Exposure Assessment and Its Impact on the Structural Organization and Morphological Peculiarities of Rat Ovaries

Results of fundamental studies of the East Siberian Institute of medical and environmental studies on the main problems of occupational health and human ecology (to the 60th anniversary of the Institute)

Effects of Dihydroquercetin on Behavior of Albino Rat Offspring with Transgenerational Chemical Body Burden

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