The influence of sex on left ventricular remodeling in arterial hypertension

Tadić, Marijana; Cuspidi, Cesare

doi:10.1007/s10741-019-09803-3

Cited by 16 publications

(15 citation statements)

References 79 publications

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“…Our finding of comparable GLS in PA and EH groups may also be explained by a low prevalence of myocardial fibrosis in the PA patients in our cohort, as demonstrated in a sub study of 32 PA patients who underwent cardiac magnetic resonance imaging with late gadolinium enhancement or T1 mapping, and who did not have increased myocardial fibrosis compared to healthy subjects [34]. In line with previous reports in EH, midwall shortening and GLS were both higher in women than in men with PA, and male sex was independently associated with lower midwall shortening and GLS in multivariable analysis in the total population [14,15].…”

Section: Discussionsupporting

confidence: 88%

“…Previous studies in EH have demonstrated that women are more prone to develop LV hypertrophy than men [11,12], and that regression of LV hypertrophy during antihypertensive treatment is attenuated in women, when obesity is co-present [13]. Several studies have reported that women with LV hypertrophy retain higher systolic function than their male counterparts [11,14,15]. Whether these sex-specific characteristics also apply for patients with PA remains to be explored.…”

Section: Introductionmentioning

confidence: 99%

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Preclinical cardiac disease in women and men with primary aldosteronism

et al. 2021

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Purpose: We tested the sex-specific associations between primary aldosteronism (PA), left ventricular (LV) hypertrophy and LV systolic myocardial function. Material and methods: Conventional and speckle tracking echocardiography was performed in 109 patients with PA and 89 controls with essential hypertension (EH). LV hypertrophy was identified if LV mass index exceeded 47.0 g/m 2.7 in women and 50.0 g/m 2.7 in men. LV systolic myocardial function was assessed by global longitudinal strain (GLS) and midwall shortening. Results: PA patients had higher prevalence of LV hypertrophy (52 vs. 21%, p < 0.001) than EH patients in both sexes, while GLS did not differ by sex or hypertension aetiology. In multivariable analyses, presence of LV hypertrophy was associated with PA and obesity in both sexes, while lower systolic myocardial function, whether measured by GLS or midwall shortening, was not associated with PA, but primarily with higher body mass index and LV mass index, respectively, in both sexes (all p < 0.05). Conclusion: Having PA was associated with higher prevalence of LV hypertrophy both in women and men, compared to EH. PA was not associated with LV systolic myocardial function in either sex.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Preclinical cardiac disease in women and men with primary aldosteronism

et al. 2021

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“…These observations together explain why the elderly women are at a high risk of developing HF. Several mechanisms have been proposed to explain the sex-differences in LV remodeling, and the current study suggested that sex-difference in vascular ageing might contribute to these observations [37,38]. Arterial stiffness, a marker of vascular ageing, can be estimated through measuring PP.…”

Section: Sex-related Left Ventricular Structural Alteration and Left ...mentioning

confidence: 59%

Influences of achieved SBP on age and sex-related left ventricular structural alteration in community hypertensive populations

Cai

Liu

Zhou

et al. 2022

Journal of Hypertension

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Objective: To evaluate age and sex-related left ventricular (LV) structural alteration in community hypertensive populations, and to explore whether achieved systolic blood pressure (SBP) (<120, < 130 and <140 mmHg) would modify the association between age and sex with LV structural alteration.Method: A total of 1419 community hypertensive people (mean age 61 years, women 50.5%) without cardiovascular disease and left ventricular hypertrophy (LVH) at baseline were included. LV structural measures were assessed using transthoracic echocardiography at baseline and at follow-up. Age and sex-related LV structural alteration was evaluated using linear and Cox regression analysis as appropriate.Results: Per 10 years increase in age was associated with positive alteration of LV mass (LVM) index (coefficient-b: 2.63) and LV mass-to-volume (LVMV) ratio (coefficient-b: 0.04). Female sex was associated with positive alteration of LVM index (coefficient-b: 4.87) and LVMV ratio (coefficient-b: 0.05). After a median follow-up of 4years, compared to men, women had a higher rate of LVH (36.8% vs. 11.5%, P < 0.001). The association between age and incident LVH was nonsignificant when achieved SBP <120 mmHg. The association between female sex and LVM index alteration was nonsignificant when achieved SBP <120mmHg and <130mmHg. Conclusion:Age and female sex were associated with a phenotype of LV remodeling which was featured by increased LVM index and concentric remodeling. Women had a higher risk of developing LVH. A lower achieved SBP conferred greater effects on mitigating age and sex-related LV structural alteration.

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“…Impaired strain in various layers of the left ventricular wall in the background of hypertension has been studied and confirmed in various studies, although the stimulatory effect of diastolic dysfunction in such disorder has been indicated in few studies. In Tadic et al study (18), GLS was significantly lower in hypertensive men than in normotensive patients. The major factor in the development of left ventricular remodeling following hypertension was the effect of sex hormones and its associated biohormonal systems.…”

Section: Discussionmentioning

confidence: 81%

Evaluation of functional indices of left ventricular wall layers using layer-specific strain analysis in normotensive and hypertensive patients

Toufan¹,

Aghdam

shahabi³

2020

Preprint

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Background: In systemic hypertension, left ventricular remodeling results in an increase in ventricular wall thickness due to augmented ventricular afterload. Most studies on myocardial function in hypertensives are performed using imaging techniques in which the evaluation of myocardial wall thickness is performed without separating the LV myocardial triple layers from the endocardium to the pericardium. The specific myocardial function of each layer or layer-specific in both segmental and global form can also be examined using left ventricular strain analysis. The purpose of the present study was to evaluate the functional indices of each layer of the left ventricular myocardium using layer-specific strain analysis and also to evaluate the relationship between ventricular structural remodeling with the functional changes of the ventricle in each layer of the myocardium in hypertensive and normotensive individuals. Methods: Eighty eight patients (46.6% were normotensive and 53.4% were hypertensive) underwent two-dimensional echocardiography and longitudinal and circumferential strain indices were analyzed in all three layers. All parameters evaluated in terms of diastolic dysfunction were compared between two groups. Results: In patients with diastolic dysfunction, GLS and GCS strains significantly decreased in epicardial and mid myocardial layers in hypertensive patients, but these changes did not revealed in those without diastolic dysfunction. Conclusion: Decreases in GLS and GCS indices of the ventricular wall in mid myocardium and epicardial layers are predictable in the context of hypertension, and these changes in strain are evident in patients with ventricular diastolic dysfunctio

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The influence of sex on left ventricular remodeling in arterial hypertension

Cited by 16 publications

References 79 publications

Preclinical cardiac disease in women and men with primary aldosteronism

Preclinical cardiac disease in women and men with primary aldosteronism

Influences of achieved SBP on age and sex-related left ventricular structural alteration in community hypertensive populations

Evaluation of functional indices of left ventricular wall layers using layer-specific strain analysis in normotensive and hypertensive patients

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