The influence of Sacoglottis gabonensis stem bark extract and its isolate bergenin, Nigerian alcoholic beverage additives, on the metabolic and haematological side effects of 2,4-dinitrophenyl hydrazine-induced tissue damage

., H.C.C. Maduka; Okoye, Z. S. C.; Eje, A

doi:10.1016/s1537-1891(03)00042-9

Cited by 25 publications

(13 citation statements)

References 13 publications

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“…These results are in part similar and contrary to those of [15] and [16] which showed that the total aqueous extract of Sacoglottis gabonensis does not cause changes in the erythrocyte and leukocyte lines. Indeed [15], studying the influence of Sacoglottis gabonensis on the side effects of 2,4-dinitrophenylhydrazine on blood and cell metabolism, showed that administration of Sacoglottis gabonensis to rats did not alter the levels of red globules, hemoglobin, hematocrit, white blood cells, lymphocytes, neutrophils and monocytes.…”

Section: Hematological and Biochemical Examinationssupporting

confidence: 56%

“…Indeed [15], studying the influence of Sacoglottis gabonensis on the side effects of 2,4-dinitrophenylhydrazine on blood and cell metabolism, showed that administration of Sacoglottis gabonensis to rats did not alter the levels of red globules, hemoglobin, hematocrit, white blood cells, lymphocytes, neutrophils and monocytes. There was no significant difference (p>0.05) in glucose (lot II) treated with EEar after 14 d, whereas that in the control batch (lot I) showed a significant difference (p<0.05).…”

Section: Hematological and Biochemical Examinationsmentioning

confidence: 99%

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Acute Toxicity Evaluation of Ethanolic Extract of Aristolochia Albida Duch. Leaves on Wistar Rats Liver and Kidney Functions

Guinnin

Klotoé

Atègbo

2017

Int J Pharm Pharm Sci

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Objective: Aristolochia albida Duch is frequently used by alternative medicine to treat some pathologies like hepatitis. Our main objective was to evaluate the acute oral toxicity of the ethanolic extract of this plant.Methods: Exploratory tests for acute oral toxicity are performed in vivo on Wistar albino rats in a limit test of 2000 mg/kg for 14 d in accordance with the OECD Guidelines 423. The clinical signs were observed every day, followed by measurement of body weight change, the haematological and biochemical examinations were executed and statistical analysis was performed. Results:The various clinical signs observed after administration and for 14 d were recorded and no mortality was observed. With the exception of white blood cells, mean cell volume and platelets with statistically significant difference in control (p<0.05), all the haematological parameters showed an insignificant statistical difference to the control ratio (p>0.05). For biochemical parameters, except blood glucose and total protein of control batches, which show a significant statistical difference after 14 d (p>0.05), all the biochemical parameters show the statistically insignificant difference for test and controls batches (p>0.05) as well as the weight variation of the animals. Conclusion:The ethanolic extract of the leaves of A. albida Duch (EEAr) had not toxic effect on the biochemical and hematological parameters studied at a dose of 2000 mg/kg. The lethal dose is therefore over 2000 mg/kg.

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Section: Hematological and Biochemical Examinationssupporting

confidence: 56%

Section: Hematological and Biochemical Examinationsmentioning

confidence: 99%

Acute Toxicity Evaluation of Ethanolic Extract of Aristolochia Albida Duch. Leaves on Wistar Rats Liver and Kidney Functions

Guinnin

Klotoé

Atègbo

2017

Int J Pharm Pharm Sci

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“…and S. nodiflora provoked no changes in erythrocytes and leukocytes cell strains. This result is similar with that of Maduka et al (2003). Furtheremore, the results of the study of influence of Sacoglottis gabonensis on secondary effects of 2.4-dinitrophénylhydrazin in bood and cell 1223 metabolism showed that the use of Sacoglottis gabonensis for rats don't modify the level of red blood cells, hemoglobin, hematocrit, white blood cells, lymphocytes, neutrophils and monocytes.…”

Section: This Impact Ofsupporting

confidence: 85%

VALORIZATION OF CISSUS POPULNEA (GUILL & PERR) AND SYNEDRELLA NODIFLORA (L.) GAERTN IN RABBIT BREEDING IN BENIN: IMPACT ON REPRODUCTIVE PERFORMANCES, BLOOD CELLS COUNT AND HEMATOCRIT.

Aholou¹,

Tongan²,

Daouda³

et al. 2017

IJAR

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“…Xenobiotic oxidants cause elevations in lipid peroxides in red cells (25) and accompanying reductions in physiological parameters such as the above red cell maturation factors, RBC, WBC and HB (2,21). The sparing of RBC and Hb by the aqueous leaf extract of Moringa oleifera suggests cytoprotection and antioxidant properties.…”

Section: IVmentioning

confidence: 99%

“…Such plants include Sacoglottis gabonensis, a Nigerian alcoholic beverage additive (1,2) and Moringa oleifera (unpublished). Moringa oleifera, horse radish tree is a pan-tropical species known by various regional names as benzolive, drumstick tree, kelor, marango, mulangay, nebedgy, saijhan and sajhan.…”

Section: Introductionmentioning

confidence: 99%

Protective Role of Moringa Oleifera Lam Aqueous Leaf Extract on Some Excretory Products and Hematological Parameters in Acetaminophen Induced Albino Rats

.¹,

Daja²,

Gadaka³

et al. 2014

IOSRJNHS

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Background: Aqueous leaf extract of Moringa oleifera (MO) was evaluated for its ability to ameliorateacetaminophen-induced toxicity in albino rats using serum urea and creatinine levels as well as heamatological parameters as indices of evaluation. Methods: Groups of five Albino rats were pre-administered with MO (200 and 400mg/kg/bw) prior to a single dose administration of acetaminophen (3g/kg body weight). Haematological and biochemical indices were determined using standard methods. Results: Pretreatment of 200mg and 400 mg/kg body weight prior to acetaminophen administration caused significant reductions(p<0.05) in the test groups when compared to normal control groups in the levels of urea and creatinine in serum. There were no significant difference in the haematological parameters between the test and control groups. Conclusion: Results suggest that aqueous extract of Moringa oleifera administration would affect biologicalresponse to acetaminophen in kidney functions.

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The influence of Sacoglottis gabonensis stem bark extract and its isolate bergenin, Nigerian alcoholic beverage additives, on the metabolic and haematological side effects of 2,4-dinitrophenyl hydrazine-induced tissue damage

Cited by 25 publications

References 13 publications

Acute Toxicity Evaluation of Ethanolic Extract of Aristolochia Albida Duch. Leaves on Wistar Rats Liver and Kidney Functions

Acute Toxicity Evaluation of Ethanolic Extract of Aristolochia Albida Duch. Leaves on Wistar Rats Liver and Kidney Functions

VALORIZATION OF CISSUS POPULNEA (GUILL & PERR) AND SYNEDRELLA NODIFLORA (L.) GAERTN IN RABBIT BREEDING IN BENIN: IMPACT ON REPRODUCTIVE PERFORMANCES, BLOOD CELLS COUNT AND HEMATOCRIT.

Protective Role of Moringa Oleifera Lam Aqueous Leaf Extract on Some Excretory Products and Hematological Parameters in Acetaminophen Induced Albino Rats

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