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Aims:This work aimed at evaluating the effects of Dacroydes edulis pulp oil extract on serum lipid profile of male-albino Wistar rats at various concentrations. This was done by assessing serum total cholesterol (TCHOL), high density lipoprotein (HDL) and low density lipoprotein (LDL) levels. This is in order to widen its utilization for the treatment and control of cardiovascular diseases. Study Design: The research was carried out by grouping the rats into four groups of five rats each (groups 1-4). The groupings were according to the doses of the extract given. Methods: The oil extract was done using n-lexane in soxhlet apparatus at room temperature and Original Research Articlethe solvent evaporated using rotary evaporation (model TT22, USA) at 50°C. Twenty male albino Wistar rats of 180-200 g were grouped into 4. Groups 1 were the control while groups 2,3 and 4 were given, 5 mg/kg/d, 10 mg/kg/d and 20 mg/kg/d of the pulp oil extract for 21 days. Blood samples were collected for serum lipid profile via ocular puncture using heparinized capillary tubes. Serum lipid profile Levels were analyzed using VIS-UV spectrophotometer (model 752, China). Results were analyzed using SPSS version 21 statistical software using ANOVA analysis.

Background: Aqueous leaf extract of Moringa oleifera (MO) was evaluated for its ability to ameliorateacetaminophen-induced toxicity in albino rats using serum urea and creatinine levels as well as heamatological parameters as indices of evaluation. Methods: Groups of five Albino rats were pre-administered with MO (200 and 400mg/kg/bw) prior to a single dose administration of acetaminophen (3g/kg body weight). Haematological and biochemical indices were determined using standard methods. Results: Pretreatment of 200mg and 400 mg/kg body weight prior to acetaminophen administration caused significant reductions(p<0.05) in the test groups when compared to normal control groups in the levels of urea and creatinine in serum. There were no significant difference in the haematological parameters between the test and control groups. Conclusion: Results suggest that aqueous extract of Moringa oleifera administration would affect biologicalresponse to acetaminophen in kidney functions.

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