The influence of medication on erectile function

Meinhardt, W.; Rf, Kropman; Vermeij, P.; Nijeholt, Aab Lycklama à; Zwartendijk, J.

doi:10.1038/sj.ijir.3900257

Cited by 38 publications

(19 citation statements)

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“…14 Apart from potential disadvantageous effects of the drop in blood pressure following beta-blocker treatment the local balance of alpha and beta-adrenergic function may be pertubated and interfer with the vascular events during erection. 2,15,16 According to the results of our study educational, social as well as psychological factors might play the dominant role in the development of impotence as has been indicated in other studies dealing with quality of life in patients with coronary heart disease. 1,17 Further work is however needed to clarify the role of betablockers on the erectile function in different and larger populations.…”

Section: Discussionmentioning

confidence: 87%

“…Beta-blockers seem to disturb the delicate balance between alpha-and beta-adrenergic nerve fibers. 2 However, it is surprising and unclear why not all or the majority of patients experience such side effects. In the following we report on a prospective, randomized and placebo controlled trial on the effect of beta-blockers on the sexual performance in men with coronary artery disease.…”

Section: Introductionmentioning

confidence: 99%

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Effects of beta-blockers on sexual performance in men with coronary heart disease. A prospective, randomized and double blinded study

et al. 2001

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In a prospective trial assessing the effects of beta-blockers on sexual function men with coronary heart disease were randomized to a 4 month treatment with sustained release metoprolol 95 mg or placebo. A standardized and validated self-report questionnaire (KEED ¼ Kö lner Erhebungsbogen der Erektilen Dysfunktion) dealing with several aspects of sexual performance in men had to be answered at the beginning and at the end of the study. Based on 65 patients completing the study, sex life seemed unaffected by metoprolol treatment.

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Effects of beta-blockers on sexual performance in men with coronary heart disease. A prospective, randomized and double blinded study

et al. 2001

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“…4 It has been suggested that this may be because of the change in balance between alpha and beta sympathetic influence, resulting in insufficient antagonism of alpha-1 vasoconstriction. 5 Many of these studies are biased by relatively heterogeneous groups of patients having organic or psychogenic (or both) predisposing factors in addition to drugrelated causes. We tried to minimize these confounding factors and investigated relatively young healthy men having mainly hypertension as a risk factor of vascular disease.…”

Section: Discussionmentioning

confidence: 99%

Effects of moxonidine and metoprolol in penile circulation in hypertensive men with erectile dysfunction: results of a pilot study

Piha¹,

Kaaja

2003

Int J Impot Res

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Centrally acting (moxonidine) and peripherally acting (metoprolol) sympatholytic agents might have different actions upon penile circulation in hypertensive men with erectile dysfunction. A total of 11 nonsmoking, hypertensive but otherwise healthy men with erectile dysfunction were studied after 8 weeks on moxonidine monotherapy (0.4 mg per day, increased to 0.6 mg if needed) and then after 8 weeks of metoprolol monotherapy (100 mg per day, increased to 200 mg if needed) in a crossover design. At the end of each treatment phase, the subjects were asked about their subjective erectile capacity (nocturnal and coital erections), and resting and stimulated (after intracavernosal injection of a mixture of alprostadil and phentolamine) penile deep artery diameters and systolic peak velocities were measured by color Doppler ultrasonography. There were no significant differences in blood pressure after either therapy. The change from earlier antihypertensive therapy, moxonidine produced significant subjective amelioration of sexual dysfunction in 9/11 of the men (Po0.001), whereas 9/11 returned to impaired dysfunction after crossover to metoprolol treatment. Resting and stimulated deep penile diameters and peak systolic velocities were higher after moxonidine treatment compared with metoprolol (diameters: Po0.004, Po0.0001; velocities: Po0.008, Po0.038). The centrally acting sympatholytic agent moxonidine seems to improve erectile function both subjectively and objectively and has a better effect on penile circulation compared with the peripherally acting sympatholytic agent metoprolol.

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“…However, this association is sometimes difficult to prove and is probably often underreported. Drugs commonly reported to be associated with ED are cardiovascular drugs, histamine-2 receptor antagonists, hormones, anticholinergics, psychotropics, and certain cytotoxic medications (Meinhardt, Kropman, Vermeij, Nijeholt, & Zwartendijk, 1997). Lifestylerelated risk factors for ED include chronic alcoholism and chronic use of marijuana, codeine, meperidine, methadone, and heroin (Lewis, 2001).…”

Section: Medicationsmentioning

confidence: 99%

Epidemiology of Male Sexual Dysfunction

Hatzimouratidis

2007

Am J Mens Health

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The influence of medication on erectile function

Cited by 38 publications

References 50 publications

Effects of beta-blockers on sexual performance in men with coronary heart disease. A prospective, randomized and double blinded study

Effects of beta-blockers on sexual performance in men with coronary heart disease. A prospective, randomized and double blinded study

Effects of moxonidine and metoprolol in penile circulation in hypertensive men with erectile dysfunction: results of a pilot study

Epidemiology of Male Sexual Dysfunction

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