Effects of beta-blockers on sexual performance in men with coronary heart disease. A prospective, randomized and double blinded study

Franzen, D.; Metha, Angela; Seifert, Nathalie; Braun, M.; Hw, Höpp

doi:10.1038/sj.ijir.3900787

Cited by 47 publications

(30 citation statements)

References 17 publications

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“…16,32 Moreover, the KEED score, previously validated in the general population around Cologne, Germany, in the course of the Cologne Male Survey, was used as a control. 2,25 Results from both questionnaires correlated significantly in the present study population of patients with the metabolic syndrome. Thus, results are suggested to be valid and likely to be independent from incorrect response to the questionnaires.…”

Section: Methodology and Limitationsmentioning

confidence: 58%

“…These results are consistent with prior findings, which demonstrated a decrease in erectile function in patients treated with the calcium channel blocker nifedipine and the diuretic chlorthalidone, but not in patients who received b-receptor blockers. 20,[23][24][25][26] The adverse influence of treatment with statins on erectile function is somewhat surprising, taking into account the pleiotropic effects of statins, as for instance the improvement of endothelial function due to an upregulation of the endothelial nitric oxide synthase. 27,28 Recently the hydroxymethylglutaryl (HMG) coenzyme A reductase inhibitor rosuvastatin has been shown to exert beneficial effects on erectile function in diabetic mice.…”

Section: Cardiovascular Risk Factors and Erectile Dysfunctionmentioning

confidence: 99%

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Effect of irbesartan on erectile function in patients with hypertension and metabolic syndrome

2008

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Pathogenesis of erectile dysfunction (ED) is related to endothelial dysfunction and therefore associated with cardiovascular risk factors. Patients with a combination of risk factors, as in metabolic syndrome, are thus likely to have an increased risk of developing endothelial and ED. The angiotensin receptor antagonist irbesartan has been shown to improve endothelial function in cardiovascular high-risk patients, which suggests a beneficial effect of treatment with irbesartan on ED. The aim of the present study was to determine the influence of irbesartan on ED in patients with a metabolic syndrome. A total of 1069 consecutive hypertensive patients with a metabolic syndrome from the Documentation of hypertension and metabolic syndrome in patients with Irbesartan Treatment survey were included. Patients were treated with irbesartan or the combination of irbesartan/hydrochlorothiazide for 6 months. ED was assessed using the international index of erectile function. The Cologne Evaluation Questionnaire of Erectile Dysfunction served as a control. Erectile function increased significantly (Po0.0001) after 6 months of treatment with irbesartan, irrespective of dosage and independent of additional treatment with hydrochlorothiazide. Prevalence of ED declined to 63.7% from 78.5% at baseline, along with a significant increase in orgasmic function (Po0.001) and intercourse satisfaction (Po0.001). Treatment with irbesartan alone, as well as in combination with hydrochlorothiazide is associated with an improvement of sexual desire, frequency of sexual contacts and erectile function in hypertensive patients with the metabolic syndrome. These results suggest a beneficial role of angiotensin receptor antagonists in the treatment of metabolic syndrome, and ED.

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Section: Methodology and Limitationsmentioning

confidence: 58%

Section: Cardiovascular Risk Factors and Erectile Dysfunctionmentioning

confidence: 99%

Effect of irbesartan on erectile function in patients with hypertension and metabolic syndrome

2008

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“…A prospective, randomized, double-blind study showed that patients' sex lives were unaffected by metoprolol treatment. 63 In another study, Wassertheil et al 6 demonstrated that the betaadrenergic blocker atenolol did not affect sexual function. In a study of 96 men with newly diagnosed cardiovascular disease and without ED, 31%…”

Section: Beta-adrenergic Receptor Blockersmentioning

confidence: 99%

Why do patients with heart failure suffer from erectile dysfunction? A critical review and suggestions on how to approach this problem

et al. 2005

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Chronic heart failure (HF) is an increasingly common cardiovascular disorder. The goal of healthcare providers is to optimize quality of life in this population, including sexual health. Up to 75% of patients with HF report erectile dysfunction (ED). As HF is a condition with distinct physiologic sequelae, some unique organic and psychological factors contributing to ED in this patient population have been identified, along with risk factors common to the development of coronary artery disease, HF and ED. This review describes contributing factors to ED in the setting of HF and highlights treatment considerations for this distinct patient population.

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“…Beta-blockers may cause SD depending on the degree of beta blockade. 41 Propranolol at high dose often causes ED, but lower doses of metoprolol, atenolol and carvedilol cause ED only as much as other antihypertensives. 42 Timolol eye drops have been reported to cause ED and may easily be overlooked as a causative agent.…”

Section: Effect Of Medications On Sexual Functionmentioning

confidence: 99%

Sexual dysfunction in the elderly: age or disease?

2005

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Sexuality is an important component of emotional and physical intimacy that men and women experience through their lives. Male erectile dysfunction (ED) and female sexual dysfunction increase with age. About a third of the elderly population has at least one complaint with their sexual function. However, about 60% of the elderly population expresses their interest for maintaining sexual activity. Although aging and functional decline may affect sexual function, when sexual dysfunction is diagnosed, physicians should rule out disease or side effects of medications. Common disorders related to sexual dysfunction include cardiovascular disease, diabetes, lower urinary tract symptoms and depression. Early control of cardiovascular risk factors may improve endothelial function and reduce the occurrence of ED. Treating those disorders or modifying lifestyle-related risk factors (eg obesity) may help prevent sexual dysfunction in the elderly. Sexuality is important for older adults, but interest in discussing aspects of sexual life is variable. Physicians should give their patient's opportunity to voice their concerns with sexual function and offer them alternatives for evaluation and treatment.

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Effects of beta-blockers on sexual performance in men with coronary heart disease. A prospective, randomized and double blinded study

Cited by 47 publications

References 17 publications

Effect of irbesartan on erectile function in patients with hypertension and metabolic syndrome

Effect of irbesartan on erectile function in patients with hypertension and metabolic syndrome

Why do patients with heart failure suffer from erectile dysfunction? A critical review and suggestions on how to approach this problem

Sexual dysfunction in the elderly: age or disease?

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