Epidemiology of Male Sexual Dysfunction

Hatzimouratidis, Konstantinos

doi:10.1177/1557988306298006

Cited by 33 publications

(24 citation statements)

References 149 publications

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“…Today, several lifestyle factors, e.g. smoking, physical exercise (PE) and alcohol consumption, are thought to affect the risk of developing erectile dysfunction (ED) [1][2][3][4]. The correlation between smoking, cardiovascular disease (CVD) and ED is so strong that ED has been suggested as a screening tool for cardiovascular disorders [5,6].…”

Section: Introductionmentioning

confidence: 99%

Influence of age and changes over time on erectile dysfunction: Results from two large cross-sectional surveys 11 years apart

Stranne

Malmsten

Areskoug

et al. 2012

Scandinavian Journal of Urology

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Section: Introductionmentioning

confidence: 99%

Influence of age and changes over time on erectile dysfunction: Results from two large cross-sectional surveys 11 years apart

Stranne

Malmsten

Areskoug

et al. 2012

Scandinavian Journal of Urology

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“…Further exploration of these compounds may lead to the development of valuable medicines for treating, among others, erectogenic conditions [76][77][78], botulism [97,98], malignant neoplasms [114,116,222,223], autoimmune disorders [133], microbial [161,165,210,215,245] and parasitic infections [147], and chronic pain [207], as well as improved bacterial endotoxin detection [159] and innovative sunscreens [178]. These advances are much needed when considering the high global incidence of erectogenic conditions [250], autoimmune disorders [251], and cancer [252], the worldwide threat of bioterrorism [99], and the increasing resistance of microbial [253] and parasitic infections [254] to exisiting medications. Importantly, the very high specificity and potency for particular molecular targets of these compounds is likely to guarantee excellent therapeutic efficacy with minimal toxicity.…”

Section: Discussionmentioning

confidence: 99%

Exploring the global animal biodiversity in the search for new drugs – Spiders, scorpions, horseshoe crabs, sea spiders, centipedes, and millipedes

Mans¹

2017

J Transl Sci

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Drug discovery and development programs have historically mainly focused on plants with medicinal properties and the extensive knowledge of traditional healers about these plants. More recently, the vast array of marine invertebrates and insects throughout the world have been recognized as additional sources for identifying unusual lead compounds to obtain structurally novel and mechanistically unique therapeutics. The results from these efforts are encouraging and have yielded a number of clinically useful drugs. However, many arthropods other than insects -such as spiders, scorpions, horseshoe crabs, sea spiders, centipedes, and millipedes -also produce hundreds of bioactive substances in their venom that may become useful in the clinic. Many of these chemicals are defensive and predatory weapons of these creatures and have been refined during millions of years of evolution to rapidly and with high specificity and high affinity shut down critical molecular targets in prey and predators. Exploration of these compounds may lead to the development of, among others, novel drugs for treating diseases caused by abnormalities in humans in the same (evolutionary conserved) molecular targets such as erectyle dysfunction, botulism, and autoimmune disorders, as well as the identification of novel antineoplastic, antimicrobial, and antiparasitic compounds. This paper addresses the importance of bioactive compounds from spiders, scorpions, horseshoe crabs, sea spiders, centipedes, and millipedes to these advances.

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“…C'est vers la fin des années 1980 que la dysfonction érectile commence à attirer l'attention. Les enquêtes de population concernant ce problème se multiplient alors, du moins en Amérique du Nord (Hatzimouratidis, 2007). En 1993, le National Institute of Health définit la dysfonction érectile comme une incapacité à atteindre ou à maintenir une érection suffisante pour avoir des rapports sexuels satisfaisants (NIH, 1993).…”

Section: Dysfonction éRectile Et Réorientation Des Attentes Normativesunclassified

“…Dans ce cas, comme dans celui de l'hypertension, on constate donc au cours d'une période charnière, -en l'occurrence ici les années 1990 -deux phénomènes convergents qui marquent l'introduction, dans la sphère publique, de la problématique de la dysfonction érectile. On note ainsi, d'une part, la mobilisation des acteurs du médical et de la santé publique autour de la production d'études scientifiques et d'enquêtes épidémiologiques (Hatzimouratidis, 2007) et, d'autre part, la mise en marché et l'intégration rapide en pratique clinique d'un médicament dont l'efficacité est jugée pour le moins spectaculaire (Harrold et al, 2000). Au cours de cette décennie, les résultats d'une enquête longitudinale améri-caine sur le vieillissement de la population masculine, la Massachussetts Male Aging Study (Feldman et al, 1994 ;Araujo et al, 2000), constituent un point tournant dans la redéfinition des contours de cette entité nosologique.…”

Section: Dysfonction éRectile Et Réorientation Des Attentes Normativesunclassified

Relations de sens et relations de fonction : risque et médicament1

Collin

2008

socsoc

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Depuis quelques décennies, les enjeux de la médecine et de la santé publique se sont réorganisés autour de transformations faisant de la santé une véritable norme. Passant d’entités discrètes à des variables continues, les deux composantes du couple santé/maladie sont désormais disposées sur un continuum borné, d’un côté, par le noyau dur de la maladie avérée et de l’autre, par sa valeur antinomique qu’incarne la santé parfaite. Entre ces pôles, l’identification de niveaux de risque constitue le principal dispositif qui conduit à une reconfiguration de la notion de prévention sur la base d’un recours croissant au médicament. À travers trois cas, l’hypertension artérielle, la dépression et la dysfonction érectile, cet article démontre comment l’évolution des raisonnements cliniques, l’arrivée de nouveaux médicaments et la mobilisation de la santé publique se conjuguent pour substituer la relation de fonction propre aux raisonnements médicaux à la relation de sens qui caractérise les dynamiques en société.For the last few decades, the questions of medicine and public health have been reorganized around changes that make health a veritable norm. From discreet entities with constant variables, the two elements of the health/sickness pair are henceforth set out on a continuum limited at one end by the hard core of proven sickness and on the other, by its antinomic value, namely perfect health. Between these poles, the identification of risk levels constitutes the main means of reconfiguring the notion of prevention on the basis of increased recourse to medication. Using three cases as illutration : high blood pressure, depression and erectile dysfunction, this paper shows how the evolution in clinical reasoning, the arrival of new medication and the mobilization of public health combine to substitute the relationship of functions proper to medical reasonings for the relationship of sense that characterises the dynamics in society.Desde hace algunas décadas, las problemáticas de la medicina y de la salud pública se han reorganizado en torno a transformaciones que hacían de la salud una verdadera norma. Pasando de entidades discretas a variables continuas, los dos componentes de la pareja salud/enfermedad están de ahora en adelante dispuestos sobre un continuo delimitado, por una parte, por el núcleo duro de la enfermedad revelada y del otro, por su valor antinómico que personifica la salud perfecta. Entre estos polos, la definición de niveles de riesgo constituye el principal dispositivo que conduce a una reconfiguración del concepto de prevención sobre la base de un recurso creciente al medicamento. A través de tres casos, el de la hipertensión arterial, la depresión y la disfunción eréctil, este artículo demuestra cómo la evolución de los razonamientos clínicos, la llegada de nuevos medicamentos y la movilización de la salud pública se conjugan para sustituir la relación de la función consustancial a los razonamientos médicos y a la relación de sentido que caracterizan las dinámicas en sociedad

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Epidemiology of Male Sexual Dysfunction

Cited by 33 publications

References 149 publications

Influence of age and changes over time on erectile dysfunction: Results from two large cross-sectional surveys 11 years apart

Influence of age and changes over time on erectile dysfunction: Results from two large cross-sectional surveys 11 years apart

Exploring the global animal biodiversity in the search for new drugs – Spiders, scorpions, horseshoe crabs, sea spiders, centipedes, and millipedes

Relations de sens et relations de fonction : risque et médicament1

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