The influence of daylight exposure on platelet 5-HT levels in patients with major depression and schizophrenia

Ljubičić, Đulijano; Stipčević, Tamara; Pivac, Nela; Jakovljević, Miro; Mück‐Šeler, Dorotea

doi:10.1016/j.jphotobiol.2007.09.002

Cited by 22 publications

(10 citation statements)

References 77 publications

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“…Heat stress is negatively associated with cognitive function and one of the plausible explanations is that it increases plasma serotonin which inhibits the production of dopamine, a neurotransmitter that is responsible for complex task performance [ 54 ]. Previous studies also reported a correlation between high temperature and altered platelet serotonin, which is associated with psychiatric disorders such as depression and schizophrenia [ 55 , 56 ]. High ambient temperature may also worsen the adverse health impacts on substance use, although patterns of substance use was not shown to change according to temperature.…”

Section: Discussionmentioning

confidence: 88%

Association between Ambient Temperatures and Mental Disorder Hospitalizations in a Subtropical City: A Time-Series Study of Hong Kong Special Administrative Region

Chan

Lam

et al. 2018

IJERPH

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Background: Mental disorders have been found to be positively associated with temperature in cool to cold climatic regions but the association in warmer regions is unclear. This study presented the short-term association between temperatures and mental disorder hospitalizations in a subtropical city with a mean annual temperature over 21 °C. Methods: Using Poisson-generalized additive models and distributed-lagged nonlinear models, daily mental disorder hospitalizations between 2002 and 2011 in Hong Kong were regressed on daily mean temperature, relative humidity, and air pollutants, adjusted for seasonal trend, long-term trend, day-of-week, and holiday. Analyses were stratified by disease class, gender and age-group. Results: 44,600 admissions were included in the analysis. Temperature was positively associated with overall mental-disorder hospitalizations (cumulative relative risk at 28 °C vs. 19.4 °C (interquartile range, lag 0–2 days) = 1.09 (95% confidence interval 1.03, 1.15)), with the strongest effect among the elderly (≥75 years old). Transient mental disorders due to conditions classified elsewhere and episodic mood disorders also showed strong positive associations with temperature. Conclusion: This study found a positive temperature–mental-disorder admissions association in a warm subtropical region and the association was most prominent among older people. With the dual effect of global warming and an aging population, targeted strategies should be designed to lower the disease burden.

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Section: Discussionmentioning

confidence: 88%

Association between Ambient Temperatures and Mental Disorder Hospitalizations in a Subtropical City: A Time-Series Study of Hong Kong Special Administrative Region

Chan

Lam

et al. 2018

IJERPH

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“…The effects of comorbid diagnosis [38], suicidal behavior [23,24,25], alcoholism [39], or the effects of different medications [24, 36] were ruled out by the study exclusion criteria. To avoid the influence of daylight exposure on platelet 5-HT values [40], patients and controls were sampled at the same time. Different phases of menstrual status might influence platelet 5-HT concentrations, platelet MAO-B activity and serum T 4 and TSH values.…”

Section: Discussionmentioning

confidence: 99%

Platelet Serotonin Concentration and Monoamine Oxidase Activity in Hypothyroid Patients

Stipčević

Kusačić-Kuna²,

Deželjin

et al. 2009

Horm Res Paediatr

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Background/Aim: The relationship between the hypothalamic-pituitary-thyroid (HPT) axis and the serotonergic (5-hydroxytryptamine, 5-HT) system is not clear. The aim of the study was to determine platelet biochemical markers (5-HT concentration and monoamine oxidase B, MAO-B, activity) in hypothyroid patients. Methods: The study included 25 medication-free female hypothyroid patients in postoperative follow-up after total thyroidectomy due to papillary thyroid carcinoma, who had not been treated with synthetic thyroxine (T₄) for 4 weeks, and 44 age-matched euthyroid healthy women. The platelet 5-HT concentration, platelet MAO-B activity, total T₄ and thyroid-stimulating hormone (TSH) levels were determined using spectrofluorimetric methods, radioimmunoassay and fluoroimmunoassay, respectively. Results: Hypothyroid patients had significantly higher TSH, significantly lower T₄ levels and platelet 5-HT concentrations, and unchanged platelet MAO-B activity than healthy subjects. A positive correlation was found between the 5-HT concentration and platelet MAO-B activity, and between the platelet MAO-B activity and T₄ in control subjects. Conclusions: Reduced platelet 5-HT concentrations in hypothyroid patients suggests a complex interaction between the 5-HT system and HPT axis activity, which could be related to the frequent occurrence of depressive symptoms in hypothyroid patients. The determination of platelet 5-HT concentrations should be considered a diagnostic tool for the evaluation of depressive symptoms in hypothyroid patients during the hormone withdrawal procedure.

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“…Daylight exposure increases not only nocturnal melatonin secretion but also platelet 5-HT values [92] and vitamin D, which in turn has been involved in the pathophysiology of depression [93]. Season might be a possible confounding factor in reduced brain serotonin turnover following selective serotonin reuptake inhibitor therapy [94] and influences the cortisol response to awakening [95].…”

Section: Depression As a Matter Of Darknessmentioning

confidence: 99%

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

Lang

Borgwardt²

2013

Cell Physiol Biochem

6,202

229

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Depression is a multicausal disorder and has been associated with the risk to develop cancer, dementia, diabetes, epilepsy and stroke. As a metabolic disorder depression has been associated with obesity, diabetes, insulin sensitivity, neuropeptide Y, glucose regulation, poor glycemic control, glucagone-like peptide-1, cholezystokinin, ghrelin, leptin, the endocannabinoid system, insulin-like growth factor and gastrin-releasing peptide. As a cardiovascular disease a close relationship exists between depression and blood pressure, heart rate, norepinephrine, sympathetic tone, vascular resistance, blood viscosity, plasma volume, intima thickness and atherosclerosis. Additionally blood coagulation, fibrinolysis, D-dimers, plasminogen activator inhibitor-1 protein, platelet activation, VEGF, plasma nitric oxide and its synthase are changed in depressed patients. As an endocrinological and stress disorder depression has been connected with the concentration of free T₄, TSH, CRH, arginine vasopressin, corticotrophin, corticosteroid release and ACTH. Depression as an inflammatory disorder is mediated by pro-inflammatory cytokines, interleukin-1, interleukin-6, TNF-alpha, soluble interleukin-2 receptors, interferon-alpha, interleukin 8, interleukin-10, hs-CRP, acute phase proteins, haptoglobin, toll like receptor 4, interleukin-1beta, mammalian target of rapamycin pathway, substance P, cyclooxygenase-2, prostaglandin-E2, lipid peroxidation levels and acid sphingomyelinase. Nutritional factors might influence depression risk, i.e. the consumption of folate, omega-3 fatty acids, monounsaturated fatty acids, olive oil, fish, fruits, vegetables, nuts, legumes, vitamin B6 and vitamin B12. The neurodegenerative hypothesis of depression explains decreased hippocampal volumes in depressed patients and changes of neurotrophic support by BDNF, erythropoietin, GDNF, FGF-2, NT3, NGF and growth hormone. In this context, a fast neuroprotective and antidepressant effect has also been observed by ketamine, which acts via the glutamatergic system. Hence, GABA, AMPA, EAAT, NMDA- and metabotropic glutamate receptors (mGluR1 to mGluR8) have gained interest in depression recently. Alternative, causative or also easy available treatment strategies beyond serotonin and noradrenaline reuptake inhibition might be a major topic of future psychiatric care. In this review, an attempt is made to overview concepts of the disease and search for perspectives on antidepressant treatment strategies beyond approved medications.

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The influence of daylight exposure on platelet 5-HT levels in patients with major depression and schizophrenia

Cited by 22 publications

References 77 publications

Association between Ambient Temperatures and Mental Disorder Hospitalizations in a Subtropical City: A Time-Series Study of Hong Kong Special Administrative Region

Association between Ambient Temperatures and Mental Disorder Hospitalizations in a Subtropical City: A Time-Series Study of Hong Kong Special Administrative Region

Platelet Serotonin Concentration and Monoamine Oxidase Activity in Hypothyroid Patients

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

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