Platelet Serotonin Concentration and Monoamine Oxidase Activity in Hypothyroid Patients

Stipčević, Tamara; Kusačić-Kuna, Sanja; Deželjin, Martina; Dodig, Damir; Koršić, Mirko; Pivac, Nela; Mück‐Šeler, Dorotea

doi:10.1159/000201109

Cited by 9 publications

(8 citation statements)

References 80 publications

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“…Hassan et al (41) observed that there was a significant decrease of plasma dopamine, norepinephrine, and serotonin levels in young and adult rats with hypothyroidism. A similar decrease in platelet serotonin concentration was also reported in a study conducted on hypothyroid patients (42). Congenital hypothyroidism leads to a lower developmental quotient and delay in psychomotor development as well as to high depression/anxiety scores in clinical samples (13,43,44,45).…”

Section: Discussionsupporting

confidence: 87%

The Effect of Congenital and Postnatal Hypothyroidism on Depression-Like Behaviors in Juvenile Rats

Erdoğan

Özgür²,

Aksu³

et al. 2016

Jcrpe

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Objective:The aim of this study was to investigate depression-like behaviors of juvenile rats with congenital and postnatal hypothyroidism.Methods:Twenty-seven newborn rat pups were used. First, 6-month-old Wistar Albino female rats were impregnated. Methimazole (0.025% wt/vol) was given to dam rats from the first day of pregnancy until postnatal 21 days (P21) to generate pups with congenital hypothyroidism (n=8), whereas in the postnatal hypothyroidism group (n=10), methimazole was given from P0 to P21. In the control group (n=9), dam rats were fed ad libitum and normal tap water. Offspring were fed with breast milk from their mothers. The behavioral parameters were measured with the juvenile forced swimming test (JFST). The procedure of JFST consisted of two sessions in two consecutive days: the 15-minute pre-test on day 1 and the 5-minute test on day 2.Results:Increased immobility and decreased climbing duration were observed in both congenital and postnatal hypothyroidism groups. Decreased swimming duration was detected in the postnatal hypothyroidism group. Both hypothyroidism groups had a lower body weight gain compared with the control group, while the congenital hypothyroidism group had the lowest body weight.Conclusion:Our results showed that hypothyroidism had negative effects on depression-like behavior as well as on growth and development. Both congenital and postnatal hypothyroidism caused an increase in immobility time in JFST. New studies are required to understand the differing results on depression-like behavior between congenital and postnatal hypothyroidism.

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Section: Discussionsupporting

confidence: 87%

The Effect of Congenital and Postnatal Hypothyroidism on Depression-Like Behaviors in Juvenile Rats

Erdoğan

Özgür²,

Aksu³

et al. 2016

Jcrpe

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“…Furthermore, there appear to be links between the HPT axis and personality traits in healthy humans (Arqué et al 1987;Balada et al 1992;Frey et al 2007). Finally, the HPT axis interacts with neurotransmitters, including serotonin and dopamine (Bauer and Whybrow 2002;Stipcevic et al 2009). Therefore, individual variation along the HPT axis has the potential to link energetics with personality.…”

Section: Mechanismsmentioning

confidence: 99%

Performance, Personality, and Energetics: Correlation, Causation, and Mechanism

Careau

Garland

2012

Physiological and Biochemical Zoology

383

467

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The study of phenotypic evolution should be an integrative endeavor that combines different approaches and crosses disciplinary and phylogenetic boundaries to consider complex traits and organisms that historically have been studied in isolation from each other. Analyses of individual variation within populations can act to bridge studies focused at the levels of morphology, physiology, biochemistry, organismal performance, behavior, and life history. For example, the study of individual variation recently facilitated the integration of behavior into the concept of a pace-of-life syndrome and effectively linked the field of energetics with research on animal personality. Here, we illustrate how studies on the pace-of-life syndrome and the energetics of personality can be integrated within a physiology-performance-behavior-fitness paradigm that includes consideration of ecological context. We first introduce key concepts and definitions and then review the rapidly expanding literature on the links between energy metabolism and personality traits commonly studied in nonhuman animals (activity, exploration, boldness, aggressiveness, sociability). We highlight some empirical literature involving mammals and squamates that demonstrates how emerging fields can develop in rather disparate ways because of historical accidents and/or particularities of different kinds of organisms. We then briefly discuss potentially interesting avenues for future conceptual and empirical research in relation to motivation, intraindividual variation, and mechanisms underlying trait correlations. The integration of performance traits within the pace-of-life-syndrome concept has the potential to fill a logical gap between the context dependency of selection and how energetics and personality are expected to interrelate. Studies of how performance abilities and/or aspects of Darwinian fitness relate to both metabolic rate and personality traits are particularly lacking.

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“…The use of MAO inhibitors in rats can change TSH release patterns, resulting in decreased transport of iodine [6,7]. Thyroid MAO enzyme is involved in the biosynthesis of thyroid hormones due to its ability to produce hydrogen peroxide [8]. When MAO is inhibited, the concentration of potent neurotransmitters such as dopamine increases which exert their inhibitory effects on the release of TSH stimulation via thyrotropin-releasing hormone (TRH) [9].…”

Section: Discussionmentioning

confidence: 99%

Effects of Alcoholic Extract of Myrtus communis L. on the Hypothalamic-Pituitary-Thyroid Axis in Rats

Changizi-Ashtiyani

Shariati

Mokhtari

et al. 2015

Zahedan J Res Med Sci

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Background:Myrtus communis leaves have the potential to affect thyroid hormone functions. Objectives: In this study, the effects of hydroalcoholic extract of M. communis on the hypothalamus-pituitary-thyroid axis and histological changes were studied. Materials and Methods:In this experimental study, 40 male rats were divided in 5 groups (n = 8): control, sham, and three experimental groups which received the extract of M. communis leaves in a minimal (0.75 mg/kg), Medium (1.5 mg/kg) and maximal amounts (3 mg/ kg), respectively. At the end of the 15th day blood samples were collected to measure triiodothyronine (T 3 ), thyroxine (T 4 ) and thyroidstimulating hormone (TSH) and to study thyroid gland tissue Results: Serum levels of T 4 and TSH in groups receiving maximum dose of the extract showed a significant decrease compared to sham group (P < 0.05). Conclusions: It is probable that some compounds in the alcoholic extract of M. communis leaves may be cause changes in serum TSH concentration and thyroid hormones.

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Platelet Serotonin Concentration and Monoamine Oxidase Activity in Hypothyroid Patients

Cited by 9 publications

References 80 publications

The Effect of Congenital and Postnatal Hypothyroidism on Depression-Like Behaviors in Juvenile Rats

The Effect of Congenital and Postnatal Hypothyroidism on Depression-Like Behaviors in Juvenile Rats

Performance, Personality, and Energetics: Correlation, Causation, and Mechanism

Effects of Alcoholic Extract of Myrtus communis L. on the Hypothalamic-Pituitary-Thyroid Axis in Rats

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