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Context:Since autism spectrum disorder (ASD) is a lifelong disease and because of its nature, the negative effects of the disease on the quality of life (QoL) of caregivers as well as patients are incontrovertible.Aims:It was aimed to evaluate the effect of the variables related to both parents and children on the QoL scores of the parents of the children with ASD.Settings and Design:This is a causality analysis study.Subjects and Methods:Questionnaire on sociodemographic/disease-related variables, QoL in Autism Questionnaire-Parent Version (QoLA-P), autism behavior checklist and Clinical Global Impression scale were assessed of 162 patients with ASD.Statistical Analysis Used:Unpaired t- test, Mann–Whitney U test, Kruskal–Wallis test, and one-way ANOVA test were used for comparing groups. The parameters found to be statistically significant for QoLA-P in different analyses were included as the independent variable in the logistic regression analysis. The backward (variable elimination) model was selected as the model in the analysis.Results:The causality has been established may be stated as the severity of autism, the presence of psychiatric disorder in the mother/father, attendance of the child at school, duration since the diagnosis of autism, and the child's medication use.Conclusions:Autism affects the QoL of caregivers. The intervention of treatment by considering the factors that affect the QoL positively or negatively may increase the QoL of caregivers.