The Influence of an Electret-Generated Electric Field Based on a Tantalum Oxide Anode on Differentiation Properties of Bone Marrow Stromal Cells from Patients with Osteoarthritis

Александрова, С.А.; Aleksandrova, O. I.; Khomutov, V. P.; Morgunov, M. S.; Блинова, М. И.

doi:10.1134/s1990519x19020020

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…It is well established that electric signals play vital roles in bone formation and fracture healing [ 8 ]. Natural bone tissues are known to exhibit piezoelectricity [ 9 ], therefore, piezoelectric materials are promising in implants because they can convert mechanical forces to electrical signals, giving them the ability to provide electrical stimulation to surrounding bone tissues without surgically implanting electrodes [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Improved activity of MC3T3-E1 cells by the exciting piezoelectric BaTiO3/TC4 using low-intensity pulsed ultrasound

Cai

Jiao

Quan

et al. 2021

Bioactive Materials

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Developing bioactive materials for bone implants to enhance bone healing and bone growth has for years been the focus of clinical research. Barium titanate (BT) is an electroactive material that can generate electrical signals in response to applied mechanical forces. In this study, a BT piezoelectric ceramic coating was synthesized on the surface of a TC4 titanium alloy, forming a BT/TC4 material, and low-intensity pulsed ultrasound (LIPUS) was then applied as a mechanical stimulus. The combined effects on the biological responses of MC3T3-E1 cells were investigated. Results of scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray diffraction showed that an uniform nanospheres -shaped BT coating was formed on TC4 substrate. Piezoelectric behaviors were observed using piezoelectric force microscopy with the piezoelectric coefficient d 33 of 0.42 pC/N. Electrochemical measures indicated that LIPUS-stimulated BT/TC4 materials could produce a microcurrent of approximately 10 μA/cm 2 . In vitro , the greatest osteogenesis (cell adhesion, proliferation, and osteogenic differentiation) was found in MC3T3-E1 cells when BT/TC4 was stimulated using LIPUS. Furthermore, the intracellular calcium ion concentration increased in these cells, possibly because opening of the L-type calcium ion channels was promoted and expression of the Ca V 1.2 protein was increased. Therefore, the piezoelectric BT/TC4 material with LIPUS loading synergistically promoted osteogenesis, rending it a potential treatment for early stage formation of reliable bone-implant contact.

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Section: Introductionmentioning

confidence: 99%

Improved activity of MC3T3-E1 cells by the exciting piezoelectric BaTiO3/TC4 using low-intensity pulsed ultrasound

Cai

Jiao

Quan

et al. 2021

Bioactive Materials

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“…Moreover, the synthesis of protein differentiation markers in BMMSCs was enhanced, and the osteogenic differentiation of BMMSCs was accompanied by significantly enhanced osteocalcin and type I collagen expression (Figure 4B). ity of osteoarthritis patient-derived BMMSCs to differentiate into osteogenic and chondrogenic lines under the influence of an electret electric field on anodized tantalum surfaces [115]. It was shown that the negatively charged tantalum electret stimulated the proliferation, migration, and metabolic activity of marrow BMMSCs and bone tissue cells.…”

Section: Bone Regenerationmentioning

confidence: 99%

Biomedical Applications of Electrets: Recent Advance and Future Perspectives

Zhang

Zhao

Xie

et al. 2023

JFB

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Recently, electrical stimulation, as a non-pharmacological physical stimulus, has been widely exploited in biomedical and clinical applications due to its ability to significantly enhance cell proliferation and differentiation. As a kind of dielectric material with permanent polarization characteristics, electrets have demonstrated tremendous potential in this field owing to their merits of low cost, stable performance, and excellent biocompatibility. This review provides a comprehensive summary of the recent advances in electrets and their biomedical applications. We first provide a brief introduction to the development of electrets, as well as typical materials and fabrication methods. Subsequently, we systematically describe the recent advances of electrets in biomedical applications, including bone regeneration, wound healing, nerve regeneration, drug delivery, and wearable electronics. Finally, the present challenges and opportunities have also been discussed in this emerging field. This review is anticipated to provide state-of-the-art insights on the electrical stimulation-related applications of electrets.

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“…Совокупность проявле ний электрета (электрическое поле и ТСТ) называ ют электретным эффектом. В настоящее время в литературе имеются публикации, сообщающие об успешных результатах лечения взрослых пациен тов с остео артрозом суставов нижних конечностей с применением ортопедического электрета [10,11,12,13]. Исследования, касающиеся эффективности применения электретов в хирургическом лечении ортопедических заболеваний тазобедренного су става у детей, в нашей стране носят единичный характер.…”

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The Use of Electret In the Surgical Treatment of Children With Perthes Disease: Early Outcomes

Bortulev

Vissarionov

Baskaeva

et al. 2022

Traumatology and Orthopedics of Russia

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Purpose to evaluate the immediate results of the use of electret IMPLESO in the surgical treatment of children with Perthes' disease Matherials and methods. The study is based on the results of a comprehensive examination of 10 patients (10 hip joints) at an average age of 7.2 0.7 years. All children underwent a triple pelvic osteotomy, which was supplemented by a transfyseal implantation IMPLESO. In the postoperative period, all patients were evaluated for the severity of pain syndrome, amplitude of movements, ultrasound, radiometry of the main indicators of the structure and stability of the hip joint, CT and MRI of the hip joints. Results. All patients had the elimination of subluxation with the restoration of hip joint stability, a significant improvement in the shape of the femoral head with the appearance of its single bone contour, the volume of the bone part of the head increased by 15-35% from the original, and there was also a significant improvement in the shape of the cartilaginous model with the complete absence of a necrosis focus in the femoral head, close to the physiological position of labrum acetabulum. Conslusion. The use of IMPLESO in the surgical treatment of children with Perthes disease in Catterall III-IV groups and hip subluxation due to the anti-inflammatory effect makes it possible to stop pain syndrome and manifestations of synovitis early after surgery, to begin rehabilitation treatment. Apparently, the osteoreparative effect of the electrostatic electret field in its own version or in combination with anti-inflammatory provides an increase in the volume of newly formed bone tissue of the head with a decrease in the area of its defect of the epiphysis with differentiation of the initial elements of the trabecular pattern, in comparison with the homogeneous high-intensity structure of the femoral head.

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The Influence of an Electret-Generated Electric Field Based on a Tantalum Oxide Anode on Differentiation Properties of Bone Marrow Stromal Cells from Patients with Osteoarthritis

Cited by 5 publications

References 7 publications

Improved activity of MC3T3-E1 cells by the exciting piezoelectric BaTiO3/TC4 using low-intensity pulsed ultrasound

Improved activity of MC3T3-E1 cells by the exciting piezoelectric BaTiO3/TC4 using low-intensity pulsed ultrasound

Biomedical Applications of Electrets: Recent Advance and Future Perspectives

The Use of Electret In the Surgical Treatment of Children With Perthes Disease: Early Outcomes

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