Biomedical Applications of Electrets: Recent Advance and Future Perspectives

Abstract

Recently, electrical stimulation, as a non-pharmacological physical stimulus, has been widely exploited in biomedical and clinical applications due to its ability to significantly enhance cell proliferation and differentiation. As a kind of dielectric material with permanent polarization characteristics, electrets have demonstrated tremendous potential in this field owing to their merits of low cost, stable performance, and excellent biocompatibility. This review provides a comprehensive summary of the recent advances in electrets and their biomedical applications. We first provide a brief introduction to the development of electrets, as well as typical materials and fabrication methods. Subsequently, we systematically describe the recent advances of electrets in biomedical applications, including bone regeneration, wound healing, nerve regeneration, drug delivery, and wearable electronics. Finally, the present challenges and opportunities have also been discussed in this emerging field. This review is anticipated to provide state-of-the-art insights on the electrical stimulation-related applications of electrets.

Impact of glioma peritumoral edema, tumor size, and tumor location on alternating electric fields (AEF) therapy in realistic 3D rat glioma models: a computational study

“…Beyond the stifling effects of peritumoral edema on the efficacy of AEF, the edema has other clinically-relevant implications including promoting GBM cell infiltration (Ohmura et al 2023), which has been found to be associated with GBM recurrence/progression (Qin et al 2021). Electrets are inorganic or macromolecular permanently-polarized agents that can provide endogenous electrical stimulation upon application of an external electric field (Grier 2001, Zhang et al 2023, and future pre-clinical research may consider using electrets to modify the electrical properties (e.g. conductivity) of the peritumoral edema in order to improve the efficacy of AEF therapy.…”

Plumbagin induces ferroptosis in colon cancer cells by regulating p53-related SLC7A11 expression

“…Samples were gathered and broken down in RIPA buffer (on ice, 30 min), and total proteins were extracted from the cell or tissue lysates via centrifugation (4 °C, 12000× g , 20 min). The proteins extracted were separated using a 10% sodium dodecyl sulfate-polyacrylamide gel and then transferred to a PVDF membrane, a semi-crystalline and non-reactive thermoplastic polymer with excellent piezoelectric properties [ 18 ]. The membrane was incubated with rabbit monoclonal primary antibodies against p-p53 (1:1000) (ab33889, Abcam, USA), p53 (1:1000) (ab32389, Abcam, USA), SLC7A11 (ab175186) and GPX4 (ab125066) at 4 °C overnight.…”

Preparation of Multi‐Functional Quaternary Ammonium Chitosan/Surfactin Hydrogel and its Application in Wound Management

“…[ 1,2 ] The healing of wounds consists of different stages such as hemostasis, inflammation, proliferation, and remodeling. [ 3,4 ] Massive bleeding from wounds often poses a serious threat to health, and if not treated promptly, it may lead to death. [ 5,6 ] Some chronic injuries have drawbacks such as prolonged inflammation, persistent infection, and insufficient angiogenesis.…”