The Inflammation-Based Glasgow Prognostic Score as a Prognostic Factor in Patients with Intensive Cardiovascular Care Unit

Abstract

Background: The Glasgow prognostic score (GPS), which is obtained from a combination of C-reactive protein (CRP) and serum albumin level, predicts poor prognoses in many cancer types. Systemic inflammation also plays an important role in pathogenesis of cardiovascular diseases. In this study, we aimed to investigate the effect of inflammation-based GPS on in-hospital and long-term outcomes in patients hospitalized in intensive cardiovascular care unit (ICCU). Methods: A total of 1004 consecutive patients admitted to ICCU were included in the study, and patients were divided into three groups based on albumin and CRP values as GPS 0, 1, and 2. Patients’ demographic, clinic, and laboratory findings were recorded. In-hospital and one-year mortality rates were compared between groups. Results: Mortality occurred in 109 (10.8%) patients in in-hospital period, 82 (8.1%) patients during follow-up period, and thus, cumulative mortality occurred in 191 (19.0%) patients. Patients with a high GPS score had a higher rate of comorbidities and represented increased inflammatory evidence. In the multivariate regression model there was independent association with in-hospital mortality in GPS 1 patients compared to GPS 0 patients (Odds ratio, (OR); 5.52, 95% CI: 1.2–16.91, p = 0.025) and in GPS 2 patients compared to GPS 0 patients (OR; 7.01, 95% CI: 1.39–35.15, p = 0.018). A higher GPS score was also associated with a prolonged ICCU and hospital stay, and increased re-hospitalization in the follow-up period. Conclusion: Inflammation based GPS is a practical tool in the prediction of worse prognosis both in in-hospital and one-year follow-up periods in ICCU patients.

Decreased albumin is associated with elevated N-terminal pro-brain natriuretic peptide and poor long-term prognosis in patients with chronic heart failure

“…[ 37 ] Previous studies have shown that albumin combined with NT-proBNP plays an important role in the diagnosis and prognosis of CHF, [ 38 – 40 ] even the Glasgow Prognostic Score based on albumin level could effectively predict the prognosis of patients with intensive cardiovascular care unit. [ 41 ] In this study, we also found that there was a significant negative correlation between albumin and NT-proBNP in CHF patients, which suggested that albumin could be used as an important marker to refine the risk stratification of CHF patients.…”

Factors influencing left ventricular ejection fraction in patients with coronary microvascular disease and obstructive coronary artery disease

“…In our research we also found out that traditional risk factors influenced the LVEF concurring the previous studies even though we were the only one, who further evaluated patients with OCAD and CMVD. In the current published articles indicated the relevance of inflammatory biomarkers particularly CRP and Pentraxin 3 as the prognostic indicators of coronary artery disease congruent with our findings even though we assessed different biomarkers [21,22].…”

Phases of fluid management and the roles of human albumin solution in perioperative and critically ill patients

“…The inflammation-based Glasgow Prognostic Score, which is derived from CRP and albumin measurements, predicts poor outcomes in many cancers and in ICU patients with cardiovascular conditions 108,109 .…”