ObjectiveThe purpose of this study is to evaluate the association between PET/CT CFR and biomarkers combined in confirming the diagnosis of coronary microvascular dysfunction.ResultsA total of 28 patients (21 males and 7 females) were included in this descriptive observational study (both qualitative and quantitative). The mean patient age was 55.50 ± 10.21 years (range 27–70 years) and the median was 56.5 years (range 49–63 years). All patients underwent Echo, CAG and PET/CT scan. Chest tightness was the most common symptom in our study. Most patients had normal blood pressure (n = 18, 64.3%) while only (n = 10, 37.5%) had hypertension, and (n = 1, 3.6%) had diabetes mellitus. The mean HDL in CMVD (n = 25) and non-CMVD (n = 3) were 1.30 ± 0.39 and 1.08 ± 0.95, respectively, indicating that the difference between the groups was statistically significant (p = 0.04). Similarly, the mean HBA1c- (glycated haemoglobin) in CMVD (n = 25) and non-CMVD (n = 3) were 5.6 ± 0.53 and 5.0 ± 0.26, respectively, with (p = 0.03). Our findings managed to show the association between biomarkers and PET/CT CFR in confirming the diagnosis of coronary microvascular dysfunction.
The aim of our research was to evaluate the relationship involving left ventricular ejection fraction, low density lipoprotein, B-type natriuretic peptide, Troponin I and coronary flow reserve, and to determine the predictors of left ventricular ejection fraction in patients with coronary microvascular disease and obstructive coronary artery disease, and in patients with coronary microvascular disease. Results: The mean age was 58.5 ± 12.5 years. In patients with obstructive coronary disease and coronary microvascular disease we found low density lipoprotein-c had significant inverse relationship with left ventricular ejection fraction, left ventricular ejection fraction also had significant negative relationship with B-type natriuretic peptide, and Troponin-I. While a significant direct relationship turned out to be observed linking left ventricular ejection fraction with coronary flow reserve. Left ventricular ejection fraction had significant negative relationship with low density lipoprotein, and B-type natriuretic peptide in patients with obstructive coronary artery disease only. Age, blood pressure, lipid levels, red cell distribution width, glycated hemoglobin, symptoms, New York heart association classification, alcohol drinking, hypertension, diabetes mellitus, troponin levels and B-type natriuretic peptide were the predictors for left ventricular ejection fraction in coronary microvascular disease patients.
Objective: The aim of our research was to evaluate the relationship involving LVEF, LDL, BNP, Troponin I and CFR, and to determine the predictors of LVEF in patients with CMVD and OCAD, and in patients with CMVD. Results: The mean age was 58.5±12.5 years. Approximately 60% of the patients were women. Chest pain was the common symptom in both conditions around 45% followed by chest tightness which was 25%. In patients OCAD and CMVD we found low density lipoprotein-c (LDL-c) had significant inverse relationship with LVEF (r= -0.323, P= 0.042), LVEF also had significant negative relationship with BNP, and Troponin-I. While a significant direct relationship turned out to be observed linking LVEF with CFR (r= 0.422, P=0.007). Left ventricular ejection fraction had significant negative relationship with LDL-C (r= -0.489, P=0.029), and BNP (r= -0.472, P=0.035) in patients with OCAD only. Age, blood pressure, lipid levels, RDW, HbA1C, symptoms, NYHA classification, Alcohol drinking, hypertension, diabetes mellitus, troponin levels and BNP were the predictors for LVEF in CMVD patients. We depicted a strong negative relationship between LVEF and biomarkers (LDL-c, BNP, Troponin-I), with a significant positive association between LVEF and CFR.
Objective: The aim of our research was to evaluate the relationship involving Left ventricular ejection fraction, low density lipoprotein, B-type natriuretic peptide, Troponin I and coronary flow reserve, and to determine the predictors of Left ventricular ejection fraction in patients with coronary microvascular disease and Obstructive coronary artery disease, and in patients with coronary microvascular disease. Results: The mean age was 58.5±12.5 years. In patients with obstructive coronary disease and coronary microvascular disease we found low density lipoprotein-c had significant inverse relationship with left ventricular ejection fraction, left ventricular ejection fraction also had significant negative relationship with B-type natriuretic peptide, and Troponin-I. While a significant direct relationship turned out to be observed linking left ventricular ejection fraction with coronary flow reserve. Left ventricular ejection fraction had significant negative relationship with low density lipoprotein, and B-type natriuretic peptide in patients with Obstructive coronary artery disease only. Age, blood pressure, lipid levels, Red cell distribution width, Glycated hemoglobin, symptoms, New York heart association classification, Alcohol drinking, hypertension, diabetes mellitus, troponin levels and B-type natriuretic peptide were the predictors for left ventricular ejection fraction in coronary microvascular disease patients.
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