Decreased albumin is associated with elevated N-terminal pro-brain natriuretic peptide and poor long-term prognosis in patients with chronic heart failure

Abstract

At present, the association between albumin, N-terminal pro-brain natriuretic peptide (NT-proBNP) and long-term prognosis in patients with chronic heart failure (CHF) is unclear. Therefore, the purpose of this study is to explore the relationship between albumin, NT-proBNP and all-cause mortality in CHF patients. Three hundred fifty two CHF patients were recruited in our study, and patients were divided into 2 groups according to the mean (37.16 g/L) of albumin concentration [low group (albumin < 37.16 g/L) and high group (albumin≥37.16 g/L)]. Differences between groups was compared by odds ratio (OR) and 95% confidence interval (CI). NT-proBNP in the high group was significantly lower than that in the low group at baseline [1811.50 (698.75–4037.00) vs 3479.50 (1538.50–7824.25), P < .001]. Spearman correlation analysis showed that there was a negative correlation between albumin and NT-pro BNP log10 transform (ρ= −0.217, P < .001). Furthermore, curve fitting further confirmed that albumin was negatively correlated with NT-proBNP. After a median follow-up of 1726 days, 90 patients in the high group occur all-cause mortality, and 98 patients in the low group occur all-cause mortality (46.88% vs 61.25%, OR = 0.29, 95% CI: 0.08–0.50). After adjusting for the selected confounding covariates by multivariate regression analysis, decreased albumin was still associated with increased all-cause mortality (high group vs low group: OR = 0.62, 95% CI: 0.39–0.97). Decreased albumin is associated with elevated NT-ProBNP and poor long-term prognosis in CHF patients. Clinicians need to pay enough attention to the nutritional status of CHF patients.

Association between N-terminal pro-B-type natriuretic peptide and clinical outcomes in bedridden patients with stroke: a cross-sectional study

“…Meanwhile, the declined serum albumin has been evidenced to be associated with many adverse cardiovascular or cerebrovascular events, including HF, atrial fibrillation, infective endocarditis and stroke. 56 Consistent with a previous study in patients with chronic HF, 57 our results demonstrated that decreased albumin was linked to elevated NT-pro-BNP in bedridden patients with stroke. ROC curve analysis showed that serum albumin with a cut-off value of 37.15 g/L may be an important factor for high levels of NT-pro-BNP in bedridden patients with stroke.…”

Fibrinogen-to-Albumin Ratio Predicts Mortality in COVID-19 Patients Admitted to the Intensive Care Unit

“…Low albumin levels in hospitalized patients at the time of admission are associated with increased short-and long-term mortality rates [4]. Previous studies have shown significant associations of hypoalbuminemia with increased cardiovascular morbidity and mortality [5,6].…”

Association of D-dimer to albumin ratio with adverse cardiovascular outcomes in ischaemic heart failure patients with diabetes mellitus: a retrospective cohort study

“…D-dimer was related to thrombosis, which contributes to the adverse events of HF 33–35 44. (2) The lower albumin in HF aggravates congestion, leading to lower intravascular colloid osmotic pressures, an increase of systematic oxidant stress and the tendency to infections 32 45 46. Therefore, albumin is a summation of several risk factors of poor outcomes.…”