The impact of type 1 diabetes on the development of the craniofacial mineralised tissues (bones and teeth): literature review

Chałas, Renata; Rudzka, Olga; Wójcik-Chęcińska, Ilona; Vodanović, Marin

doi:10.5603/fm.a2016.0001

Cited by 8 publications

(7 citation statements)

References 22 publications

(43 reference statements)

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“…[ 15 ] Morphological changes, enamel hypoplasia, and microscopic alterations in the structures of enamel, dentin, and pulp were observed in diabetic conditions, and the researchers believed that diabetes definitely affects the formation and mineralization of tooth. [ 8 9 10 11 ] With advancements in the molecular research, we are able to prick into the molecular pathways involved in those changes, and to the best of our knowledge, our systematic review is the first to compile them.…”

Section: Discussionmentioning

confidence: 99%

“…The number of studies on the effect of DM on tooth development is very few. Dental caries,[ 5 ] periodontal problems,[ 6 ] enamel hypoplasia,[ 7 ] altered rate of tooth eruption,[ 8 ] microscopic changes[ 9 ] (such as defective enamel rods, decreased rate of mineral deposition in dentin, thickened basement membrane in pulp, increased pulp stones, decreased calcium, and phosphorous content),[ 10 ] increased magnesium content, morphological alterations[ 11 ] (such as increased number of cusps), and altered tooth size are reported in the literature as the effect of this metabolic disorder. However, the molecular insight into these changes is not well understood, as the studies at molecular level are countable.…”

Section: Introductionmentioning

confidence: 99%

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Molecular insight into odontogenesis in hyperglycemic environment: A systematic review

et al. 2020

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A BSTRACT Diabetes mellitus is an endocrinal disorder affecting worldwide and the disease incidence is rising alarmingly high. The effects of diabetes on tooth development are explored by limited studies and their molecular insights are very rarely studied. This systematic review is aimed to provide the best scientific literature source on the molecular insights into odontogenesis in hyperglycemic environment caused by diabetes mellitus or by maternal diabetes on the offspring. The literature search was conducted on the databases, namely PubMed, PubMed Central, Cochrane, and Scopus. The original studies exploring the alterations in the molecular pathways of odontogenesis in diabetes mellitus were selected. Data were extracted, chosen, and evaluated by two independent researchers. At the end of thorough data search, four articles were eligible for the review. Three articles brought out the molecular pathways involved in the offspring of gestational diabetes through animal models. Fourth article was an in vitro study, which treated the stem cells in hyperglycemic environment and drafted the molecular pathway. The altered molecular pathways in dental epithelial stem cells (DESCs), dental papilla cells (DPCs), and stem cells from apical papilla were studied and empowered with statistical analysis. Thus with this systematic review, we conclude that apurinic/apyrimidinic endonuclease1 downregulation causing deoxyribonucleic acid hypermethylation and Oct4, Nanog gene silencing, activation of toll-like receptor-4/nuclear factor kappa B (TLR4/NF-κB) pathway are involved in suppressing cell proliferation and accelerated apoptosis in DESCs in high glucose environment. DPCs are suppressed from odonto differentiation by activation of TLR4 signaling and resulting inhibition of SMAD1/5/9 phosphorylation in diabetic condition. NF-κB pathway activation causes decreased cell proliferation and enhanced differentiation in apical papilla stem cells in hyperglycemia. Further studies targeting various stages of odontogenesis can reveal more molecular insight.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Molecular insight into odontogenesis in hyperglycemic environment: A systematic review

et al. 2020

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“…T1DM is characterized by chronic hyperglycemia which results from decrease or the absence of insulin secretion by pancreatic β‐cells . The pathogenesis of T1DM seems to involve in the production of autoantibodies that target proteins associated with secretory granules of β‐cells and T cell‐mediated destruction of β‐cells .…”

Section: Introductionmentioning

confidence: 99%

“…The pathogenetic effects of hyperglycemia are consequences from the overproduction of superoxide by the mitochondria, which results in oxidative stress . Hyperglycemia and resulting oxidative stress is responsible for structural and functional anomalies of tissues, which probably include enamel organ injuries that lead to enamel defects …”

Section: Introductionmentioning

confidence: 99%

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Type 1 diabetes mellitus effects on dental enamel formation revealed by microscopy and microanalysis

Silva

Medeiros

Soares

et al. 2017

J Oral Pathology Medicine

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Molar-incisor hypomineralisation prevalence in a cohort of Australian children with type 1 diabetes

Lim

Jensen

Poirier

et al. 2022

Eur Arch Paediatr Dent

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Purpose Systemic diseases or drugs administered early in life may cause a disruption in amelogenesis and contribute to the qualitative defect of enamel described as molar–incisor hypomineralisation (MIH). Therefore, an increase in prevalence of MIH in children with type 1 diabetes (T1D) may be expected as this systemic disorder is commonly diagnosed in early childhood. The aim of this study was to determine the prevalence of MIH in a cohort of children with T1D and investigate diagnosis of MIH with T1D factors. Methods Cross-sectional study of children with T1D recruited from paediatric diabetes clinics at the Women’s and Children’s Hospital (South Australia). A detailed medical history, comprehensive dental and MIH examination according to the European Academy of Paediatric Dentistry (EAPD) long form classification was collected for each child. All upper and lower first permanent molars and central incisors were scored. Results A total number of 73 participants; 35 (47.95%) males were examined including 584 teeth. The mean age of the participants was 13.25 ± 2.58 years, with a mean age of diagnosis 7.75 ± 3.58 years, and a mean HbA1c of 8.5 ± 1.6%. 42 out of 73 children (54.8%) had enamel defects on at least one of the teeth examined. However, 19.2% met the criteria for MIH. Univariate and bivariate analyses were conducted but no significant associations were noted between MIH and risk factors including diabetes control (p > 0.1). Conclusion There was a high prevalence of enamel defects and MIH amongst children with T1D. More research is required to establish association between T1D and MIH.

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The impact of type 1 diabetes on the development of the craniofacial mineralised tissues (bones and teeth): literature review

Abstract: (Folia Morphol 2016; 75, 3: 275-280)

Cited by 8 publications

References 22 publications

Molecular insight into odontogenesis in hyperglycemic environment: A systematic review

Molecular insight into odontogenesis in hyperglycemic environment: A systematic review

Type 1 diabetes mellitus effects on dental enamel formation revealed by microscopy and microanalysis

Molar-incisor hypomineralisation prevalence in a cohort of Australian children with type 1 diabetes

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