(Folia Morphol 2016; 75, 3: 275-280)

De spite sig nifi cant prog ress in the qual ity of ad he sion of ma te ri als placed into den tin, avoid ing of mi cro leak age -the ef fect of po lym eri za tion shrink age, an in her ent part ac com pa ny ing com pos ites -is still the number one prob lem of mod ern con ser va tive den tistry. As a re sult of ex po sure of the den tin/ad he sive in ter face to oral cav ity, mar ginal discol ora tions, poor mar ginal ad ap ta tion and sub se quent loss of re ten tion of the res to ra tion and fi nally re cur rent car ies, are found dur ing clini cal ex ami na tion [1,5,11,12]. Among the rea sons thereof we can in clude: leav ing the in fected den tin in pre pared cav ity, ex ces sive etch ing and/or dry ing af ter etch ing of den tin and the as so ci ated hy droly sis of col la gen by ma trix met al lo pro te inases, tem pera ture fluctua tions or oc clu sal loads [5]. While the strength of ad he sion to enamel bind ing sys tems is high, dentin-bonding ad he sives are not as du ra ble as was pre vi ously thought. Al though the im me di ate mi cro ten sile bond strength is high, it gradu ally falls 30-40% in 6-12 months [15]. The rea son for this is deg ra da tion of the hy brid layer formed by col la gen fi brils and the or ganic ma trix of den tin, re main ing hy droxya patite crys tals, resin mono mers and the sol vent [1]. This pro cess oc curs with the in volve ment of ma trix met al lopro te inases (MMPs), en dopep ti dases in volved in many physio logi cal pro cesses such as em bry onic de vel op ment, tis sue for ma tion, wound heal ing, angio gene sis, and also in patho logi cal pro cesses such as can cer, ul cers, ar thri tis,

No abstract