Molecular insight into odontogenesis in hyperglycemic environment: A systematic review

Permanent maxillary and mandibular first molars are the first permanent teeth to erupt into the oral cavity along with the mandibular incisors. It serves as an excellent record of maternal and fetal health, reflecting the prenatal, perinatal, and postnatal health and diseases. This review focuses on the molar morphogenesis, molar malformations, their etiopathogenesis, and pathologies causing specific pattern of molar malformations.

show abstract

“…Furthermore, epigenetic changes can alter the phenotype of the tooth organ without genetic alteration. [ 13 ]…”

Section: E Tiopathogenesis Of M Olar M Alformationsmentioning

confidence: 99%

“…[ 23 ] Animal studies have shown that hyperglycemic environment affects the phenotype of resulting teeth by epigenetic alterations. [ 13 ]…”

Section: Olar M Alformations In V Arious S Ystemic D Iseasesmentioning

confidence: 99%

First Molars in Permanent Dentition and Their Malformations in Various Pathologies: A Review

Yamunadevi

Ramani

Rajmohan

et al. 2021

Journal of Pharmacy and Bioallied Sciences

Self Cite

View full text Add to dashboard Cite

show abstract

“…Also empirical studies have shown the presence of missing teeth as a new find in case of Type 2 diabetes. Nowadays diabetic patients are seen to have tooth loss which is twice that of other normal individuals.Sometimes hereditary inheritance of diabetes in children could also lead to early loss of teeth [22].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Clinically Missing Permanent Teeth Due to Agenesis and Secondary Factors among Patients between 8-17 Age Group Visiting a Private Dental Hospital - an Institutional Study

Padmaja

Ramani

Reshma

2021

JPRI

View full text Add to dashboard Cite

Introduction: Congenitally missing teeth or hypodontia is a condition where some of the adult teeth fail to develop. There have been theories involving genetic and environmental factors which lead to prevalence of permanent missing teeth. Missing teeth can affect the patients and cause many other problems such as malocclusion, periodontal damage, delay in bone growth, reduced mastication and unfavourable skeletal appearance. Thus having awareness about missing teeth and the eruption sequence dentists will be able to identify the missing teeth and correct the same. Aim: The aim of this study is to analyse the prevalence of missing in the paediatric population between 8-17 years of age. Materials and Methods: The data for the study n=4453 patients was collected by analysing the case sheets of patients who visited Saveetha Dental college from June 2019- February 2021.The collected data was analysed and subjected to statistical analysis using the SPSS software by IBM of version 23. Results: From the results of the study, missing teeth in the 8 to 10 age group was highest in the second quadrant at 27.27% with most common missing teeth being left maxillary lateral incisor 15.76%, in the 11-13 age group it was highest in the third quadrant at 32.39% with most common missing teeth being left mandibular lateral incisor 16.37% and in the 14 -17 age group it was highest in first quadrant at 40.87% with the most common missing teeth being right maxillary first premolar 15.08%. It is also observed that the most common cause of missing teeth in 8-10 age group is due to congenital absence at16.46%, in 11-13 age group due to trauma at 16.46% and in 14-17 age group due to caries at 18.90%. Conclusion: Missing teeth is a very common dental anomaly encountered these days. From the present study it can be concluded that the most common cause of missing teeth was congenital absence of it. Larger community based studies should be conducted to estimate more precisely the causes for missing teeth. They are very important to be analysed so that they can prevent complications that can occur. In our study missing teeth is being analysed at an earlier age group of 8-17 reducing the chances of future complications.

show abstract

“…The risk of periodontitis in diabetic individuals increases by three folds when compared to non diabetic individuals [16]. The uncontrolled diabetes and hyperglycemia [17] results in reduced defence mechanisms and higher chances of acquiring infection leading to periodontal disease. The deep pockets, severe gingival inflammation [18], rapid bone loss and periodontal abscess is commonly seen in diabetic individuals with poor oral hygiene.…”

Section: Introductionmentioning

confidence: 99%

Correlation of Blood Sugar Levels and Chronic Periodontitis in Out-Patients Visiting a Dental Hospital

Naveenaa

Ramani

2021

JPRI

View full text Add to dashboard Cite

Introduction: Periodontitis is the inflammation of the periodontium including periodontal ligament and alveolar bone. It is a multifactorial disease which is caused by the activity of microbial invasion followed by destruction of periodontal tissues. The major risk factor involved is smoking which increases the severity of the disease and other conditions like diabetes, immunocompromised state, medication and also genetic factors. Diabetes mellitus is a disorder which is characterized to have altered glucose or impaired lipid and carbohydrate mechanisms. Diabetes has been confirmed as a major risk factor for causing periodontitis. Aim: To assess the correlation of blood sugar levels and chronic periodontitis in out-patients visiting a dental hospital. Materials and Methods: The study was conducted among the outpatients of Saveetha dental college. The data was collected and analysed from a total number of 5,35,951 patients between June 2019 - February 2021 and the sample size was 65. The data was collected from DIAS (Dental Information Archiving Software) and statistically analysed using SPSS software. Results: 52.3% of female population has chronic periodontitis where it was 47.7% in male population. From the age group of 21-30 years 20% of the chronic periodontitis individuals were diabetic, which was highest when compared to other age groups. The male population with 30.77% had diabetes and female population with 33.85% had diabetes. Conclusion: Within the limitation of the study, there exists a positive correlation between increased blood sugar levels and chronic periodontitis. And the presence of increased blood sugar levels were seen in the age groups 61-70 years and more commonly seen in the female population. So people with poorly glycemic controls must be considered as a risk factor for periodontitis and people with diabetes must be informed of the risk factors.

show abstract

Molecular insight into odontogenesis in hyperglycemic environment: A systematic review

Cited by 10 publications

References 15 publications

First Molars in Permanent Dentition and Their Malformations in Various Pathologies: A Review

First Molars in Permanent Dentition and Their Malformations in Various Pathologies: A Review

Prevalence of Clinically Missing Permanent Teeth Due to Agenesis and Secondary Factors among Patients between 8-17 Age Group Visiting a Private Dental Hospital - an Institutional Study

Correlation of Blood Sugar Levels and Chronic Periodontitis in Out-Patients Visiting a Dental Hospital

Contact Info

Product

Resources

About