The identities and anti-herpes simplex virus activity of Clinacanthus nutans and Clinacanthus siamensis

Abstract

The combination of macroscopic, microscopic and biomolecular method are able to authenticate these closely related plants and both of them have a potency to be an anti-HSV agent.

Evaluation on the effects of P. ostreatus spent mushroom compost and BAP hormone towards C. nutans in vitro culture

“…The stem is straight green with white internodes and vertical strips can be seen throughout entire stem. Similar findings by [15] was also reported on the similar new propagated plantlet morphology. in MS media do not cause changes on its physical structure.…”

Evaluation of Total Phenolic Compound and Cytotoxic Activity of Clinacanthus nutans

“…nutans is a well-known antisnake venom and antiviral agent [4] . It belongs to the family Acanthaceae which is a large family, comprised of about 250 genera and 2,500 species distributed in the world [5] .…”

“…The genus Clinacanthus comprises two species, C. nutans (Burm. f.) Lindau and C. spirei Benoist, and synonymous with Justicia nutans, J. fulgida, C. burmanni, C. siamensis [4] . C. nutans is also known as giro de flores, cocodrilo flor, e zui hua (Chinese), yudunsou (Japanese), yōuduncho (Korean), ki tajam, dandang gendis (Indonesian), belalai gajah, sabah snake grass (Malay), ki tajam (Sunda), saled pangpon tua mea, phaya yor, phak man kai, phak lin khiat (Thai), and mảnh cộng; lá cầm; bìm bịp; xương khỉ (Vietnamese) [6][7][8] .…”

“…Flowers are dense at the peak of the branch, has glandular-pubescent calyx around 3.5 cm with dull red, green base and yellow streaks. As the flowers are in dense cymes at the top of the branches and often terminating drooping horizontal [4] . Stamens are exert from the corolla.…”

“…Haetrakul, et al [30] found that C. nutans plant extract at 0.005 and 0.01% damaged Koi Fin cell line and for non-toxic concentration of this plant was 0.001%. Kunsorn, et al [4] reported the IC 50 values of C. nutans extracted with n-hexane, dichloromethane and methanol against herpes simplex virus-1 were 32.05±3.63, 44.50±2.66, and 64.93±7.00 µg/ml, respectively. Ping et al [31] reported that the repeatedly dosing of C. nutans extract at 0.3, 0.6 and 0.9 g/kg up to 14 days was proven safe in male Sprague Dawley rats without causing any adverse effects and organ damages in rats.…”