The Functional Role of Garlic and Bioactive Components in Cardiovascular and Cerebrovascular Health: What We Do Know

Ugwu, Chidiebere E; Suru, Stephen Monday

doi:10.4236/jbm.2016.410004

Cited by 12 publications

(8 citation statements)

References 65 publications

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“…Down-regulation of TLR4 can decrease production of TNF-α. SCGO also contains ajoene that has anti-thrombosis and anti-aggregation activities by preventing binding of platelets to fibrinogen receptors that in turn prevents formation of thrombi in atherosclerosis disease (17). Here we showed that treatment of mice fed a HFD with SCGO could decrease TNF-α levels in serum compared to the negative control group given HFD alone.…”

Section: Discussionmentioning

confidence: 58%

“…Single clove garlic oil (SCGO) extract is used as an herbal medicine that is thought to prevent and treat various diseases caused by HFD. Organosulfur in garlic can increase SOD activity and decrease secretion of pro-inflammatory cytokines such as TNF-α (17). The aims of this study were to determine whether SCGO extracts can ameliorate hepatic steatosis and improve oxidative status by decreasing levels of TNF-α and restoring superoxide dismutase levels in HFD.…”

Section: Introductionmentioning

confidence: 99%

“…Alliins are converted into allicin by alliinase (16). Allicin is the precursor of various allyl sulfides such as diallyl disulfide (DADS), diallyl trisulfide (DATS), diallyl sulfide (DAS), E-ajoene, Z-ajoene, thioacroleins and vinyldithiins (14,17). Single clove garlic oil (SCGO) extract is used as an herbal medicine that is thought to prevent and treat various diseases caused by HFD.…”

Section: Introductionmentioning

confidence: 99%

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Herbal Medicine from Single Clove Garlic Oil Extract Ameliorates Hepatic Steatosis and Oxidative Status in High Fat Diet Mice

Arifah

Atho'illah

Lukiati

et al. 2020

MJMS

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Introduction: High fat diet (HFD) can cause lipid accumulation and contribute to various metabolic disorders. Single clove garlic oil (SCGO) has advantages over regular garlic due to its higher amounts of organosulfide compounds in particular. This study aimed to determine the ability of SCGO extract to ameliorate hepatic steatosis and improve oxidative status by modulating expression of tumour necrosis factor α and superoxide dismutase in mice fed a HFD.Methods: Twenty-four adult male Balb/C mice were divided into six groups: i) normal diet; ii) positive control diet; iii) negative control diet; and iv) HFD with SCGO at 12.5 mg/kg body weight (mg/kg BW); v) HFD with SCGO at 25 mg/kg BW, vi) HFD with SCGO at 50 mg/kg BW. Liver weight and morphology, spleen weight, serum levels of superoxide dismutase (SOD) and tumour necrosis factor α (TNF-α), TNF-α expression in the aorta and lipid profiles were assessed at the end of the experimental period.Results: SCGO treatment was associated with significant decreases in liver and spleen weight as well as amelioration of hepatic steatosis. SCGO treatment also decreased TNF-α levels and expression. Serum levels of SOD in the SCGO groups were significantly increased compared with the negative control group. Lipid profiles were improved in the SCGO treatment groups compared with the negative control group.Conclusion: SCGO as an herbal medicine could be an effective treatment for degenerative disorders caused by HFD.

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Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Herbal Medicine from Single Clove Garlic Oil Extract Ameliorates Hepatic Steatosis and Oxidative Status in High Fat Diet Mice

Arifah

Atho'illah

Lukiati

et al. 2020

MJMS

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“…Alliaceous vegetables are processed to different products such as dietary supplements, oil macerates, essential oils, powders, and extracts. These are available in numerous fresh and dehydrated products and are utilized in a wide range of medicine and dishes [ 91 ]. The dehydrated products are produced by the dehydration of alliaceous plants in hot air tunnels.…”

Section: Plant-derived Sulfur Compounds—gsls and Oscsmentioning

confidence: 99%

Health Benefits of Plant-Derived Sulfur Compounds, Glucosinolates, and Organosulfur Compounds

et al. 2020

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The broad spectrum of the mechanism of action of immune-boosting natural compounds as well as the complex nature of the food matrices make researching the health benefits of various food products a complicated task. Moreover, many routes are involved in the action of most natural compounds that lead to the inhibition of chronic inflammation, which results in a decrease in the ability to remove a pathogen asymptomatically and is connected to various pathological events, such as cancer. A number of cancers have been associated with inflammatory processes. The current review strives to answer the question of whether plant-derived sulfur compounds could be beneficial in cancer prevention and therapy. This review focuses on the two main sources of natural sulfur compounds: alliaceous and cruciferous vegetables. Through the presentation of scientific data which deal with the study of the chosen compounds in cancer (cell lines, animal models, and human studies), the discussion of food processing’s influence on immune-boosting food content is presented. Additionally, it is demonstrated that there is still a need to precisely demonstrate the bioavailability of sulfur-containing compounds from various types of functional food, since the inappropriate preparation of vegetables can significantly reduce the content of beneficial sulfur compounds. Additionally, there is an urgent need to carry out more epidemiological studies to reveal the benefits of several natural compounds in cancer prevention and therapy.

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“…The use of medicinal plants to treat various health problems have received considerable attention since ancient times [1] and currently have applied in numerous industries such as pharmaceutical, chemical, food and cosmetic [2]. As an herbal medication, single garlic plays a role in overcoming various types of health problems, including an antithrombotic, antihypertensive, antiatherosclerosis, antihyperhomocysteinemic [3,4] and anticancer [5] effect. These benefits are due to the presence of organosulfur bioactive compounds [6,7].…”

Section: Introductionmentioning

confidence: 99%

ELICITATION OF ORGANOSULFUR BIOACTIVE COMPOUNDS WITH Fe3+ AND Zn2+ IN CELL SUSPENSION CULTURE OF SINGLE GARLIC (ALLIUM SATIVUM L.)

SETIOWATI¹

2022

FARMACIA

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Single garlic (Allium sativum L.) is an herbal plant that is rich in organosulfur compounds and widely used for the treatment in health problems such as high blood pressure, hypercholesterolemia, atherosclerosis and cancer. This study aims to investigate the different concentrations effect of Fe 3+ and Zn 2+ elicitor (0, 0.1, 0.2, 0.3, 0.4, 0.5 mM, respectively) in single garlic cell suspension culture. The formation of suspension culture was done by culturing the callus in Murashige and Skoog liquid medium. The HPLC analysis revealed the presence of 30 organosulfur compounds. The Fe 3+ and Zn 2+ elicitors can increase the growth of cell suspension culture and production of organosulfur compounds. The highest of fresh weight, dry weight, settled cell volume, growth index were produced in the medium augmented by 0.5 mM Fe 3+ and 0.5 mM Zn 2+ , while organosulfur compounds increase with 0.3 mM Zn 2+ (2-fold) and 0.5 mM Fe 3+ (1.5-fold). The Fe 3+ and Zn 2+ metal ions are effective elicitors to increase the production of organosulfur bioactive compounds. RezumatUsturoiul monobulb (Allium sativum L.) este o plantă bogată în compuși organosulfurici și este utilizat pe scară largă pentru tratamentul diferitelor probleme de sănătate, cum ar fi hipertensiunea arterială, hipercolesterolemia, ateroscleroza și cancerul. Acest studiu își propune să investigheze efectul concentrațiilor diferite ale elicitorilor Fe 3+ și Zn 2+ (0, 0,1, 0,2, 0,3, 0,4 și 0,5 mM) asupra unei suspensii celulare provenite de la Allium sativum. Suspensia a fost obținută prin cultivarea calusului în mediul lichid Murashige și Skoog. Analiza HPLC a relevat prezența a 30 de tipuri de compuși organosulfurici. Elicitorii Fe 3+ și Zn 2+ pot determina înmulțirea celulelor în suspensie și biosinteza de compuși organosulfurici. S-au determinat următorii parametrii: greutatea proaspătă și uscată, volumul celular și indicele de creștere. Concentrațiile de 0,5 mM Fe 3+ și 0,5 mM Zn 2+ au avut cel mai important efect asupra acestor parametri. Concentrația compușilor organosulfurici a crescut sub acțiunea Zn 2+ 0,3 mM (de 2 ori) și respectiv Fe 3+ 0,5 mM (de 1,5 ori). Ionii metalici Fe 3+ și Zn 2+ sunt elicitori eficienți pentru valorificarea producției de compuși organosulfurici bioactivi.

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The Functional Role of Garlic and Bioactive Components in Cardiovascular and Cerebrovascular Health: What We Do Know

Cited by 12 publications

References 65 publications

Herbal Medicine from Single Clove Garlic Oil Extract Ameliorates Hepatic Steatosis and Oxidative Status in High Fat Diet Mice

Herbal Medicine from Single Clove Garlic Oil Extract Ameliorates Hepatic Steatosis and Oxidative Status in High Fat Diet Mice

Health Benefits of Plant-Derived Sulfur Compounds, Glucosinolates, and Organosulfur Compounds

ELICITATION OF ORGANOSULFUR BIOACTIVE COMPOUNDS WITH Fe3+ AND Zn2+ IN CELL SUSPENSION CULTURE OF SINGLE GARLIC (ALLIUM SATIVUM L.)

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