Introduction: High fat diet (HFD) can cause lipid accumulation and contribute to various metabolic disorders. Single clove garlic oil (SCGO) has advantages over regular garlic due to its higher amounts of organosulfide compounds in particular. This study aimed to determine the ability of SCGO extract to ameliorate hepatic steatosis and improve oxidative status by modulating expression of tumour necrosis factor α and superoxide dismutase in mice fed a HFD.Methods: Twenty-four adult male Balb/C mice were divided into six groups: i) normal diet; ii) positive control diet; iii) negative control diet; and iv) HFD with SCGO at 12.5 mg/kg body weight (mg/kg BW); v) HFD with SCGO at 25 mg/kg BW, vi) HFD with SCGO at 50 mg/kg BW. Liver weight and morphology, spleen weight, serum levels of superoxide dismutase (SOD) and tumour necrosis factor α (TNF-α), TNF-α expression in the aorta and lipid profiles were assessed at the end of the experimental period.Results: SCGO treatment was associated with significant decreases in liver and spleen weight as well as amelioration of hepatic steatosis. SCGO treatment also decreased TNF-α levels and expression. Serum levels of SOD in the SCGO groups were significantly increased compared with the negative control group. Lipid profiles were improved in the SCGO treatment groups compared with the negative control group.Conclusion: SCGO as an herbal medicine could be an effective treatment for degenerative disorders caused by HFD.
Tengger tribe is one of the tribes in Indonesia that live around Bromo Tengger Semeru National Park (BTSNP) area. BTSNP area inhabited by the Tengger tribe people is an area in Indonesia with high biodiversity. The local wisdom of the Tengger tribe is in terms of the use of natural resources for various requirements of their lives. This study aimed to explore the utilization of multiple plants by the Tengger tribe in Ngadas and Ranupani villages around BTSNP. This research used surveys and group discussion (GDF) methods involving traditional leaders and some people of the Tengger tribe. The data obtained were analyzed descriptively and qualitatively. The results showed that the plants used for traditional medicinal materials were 25 species, food sources were 17 species, industrial materials and household were 11 species, building materials were 17 species, ecological functions were nine species, and traditional ritual ceremonies were seven species. The Tengger tribe used the natural resources in the form cultivation plants and non-cultivation plants to support in all aspects of their livelihood.
AbstrakDi Indonesia, kekurangan Vitamin A masih menjadi masalah kesehatan masyarakat yang penting seperti terlihat pada balita penderita vitamin A defisiensi subklinis yang tinggi (50%). Hal tersebut akan berpengaruh terhadap berbagai fungsi tubuh yang antara lain meliputi sistem imun, penglihatan, sistem reproduksi dan diferensiasi sel. Tujuan dari penelitian ini adalah untuk mengetahui kontribusi konsumsi minyak yang diperkaya vitamin A dalam memperbaiki status vitamin A dan hemoglobin balita. Penelitian dengan disain studi intervensi Before-After ini dilaksanakan pada anak sehat berusia 7-10 tahun yang diberi obat cacing sebelum intervensi dilakukan. Pengukuran serum retinol dan hemoglobin dilakukan sebelum dan 3 bulan setelah intervensi . Minyak yang difortifikasi vitamin A telah disediakan di warung/ toko di sekitar tempat tinggal responden. Untuk meningkatkan demand, penelitian ini dilengkapi dengan pendekatan pemasaran sosial yang dilakukan pihak lain. Secara umum tidak terlihat perubahan status gizi, tetapi prevalensi anemia turun dari 21,8% menjadi 11,6%. Sementara, prevalens vitamin A defisiensi ditemukan lebih rendah pada anak yang mengkonsumsi ≥12 minggu (26,6%) daripada yang mengkonsumsi < 12 minggu (42%) . Hasil tersebut dapat dijadikan pertimbangan untuk merekomendasikan agar minyak difortifikasi vitamin A. Kata kunci : Defisiensi vitamin A, anak sekolah, minyak fortifikasi AbstractVitamin A deficiency (VAD) remains as one of significant public health problems in Indonesia. Around 50% of under five children are suffering from subclinical VAD. Deficiency of vitamin A will affect several important role in the body, such as immune system, vision, reproductive system and cell differentiation. Therefore, guarding Indonesian children to be free from VAD is crucial for their quality as Human Resources. We assessed the impact of the consumption of vitamin A fortified cooking oil on the improvement of vitamin A and hemoglobin status among school children in urban slum area in Makassar City. The study was an intervention design Before-After. Healthy school children 7-10 years were selected from schools and de-wormed before the intervention. Serum retinol and hemoglobin was measured at baseline and at 3 months after. Fortified oil was made available through distribution at shops and accompanied with social marketing. Eventhough overall there was no change in VAD prevalence, the VAD prevalence is lower among children who consumed fortified oil ≥12 weeks (26.6%) compared to those who consumed <12 weeks (42%). Prevalence of anemia decreased from 21.8% to 11.6%. We recommended that fortified oil is made mandatory.
Background and Aim: Hyperglycemia increases advanced glycation end-product (AGE) production, and the activity of receptor for AGE (RAGE) in testis, which leads to testicular histopathological damage and infertility. This research investigated the effect of black soybean tempeh (BST), purple sweet potato (PSP), and its combination on AGE and RAGE expression and spermatozoa quality in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: The rats were given high-fat diets for 5 weeks, then were injected intraperitoneally with multiple low doses of STZ (30 mg/kg body weight). Diabetes mellitus (DM) rats were divided into seven groups: DM, DM+glibenclamide, DM+BST, DM+PSP, and DM+combination of BST and PSP in ratio 1:3, 2:2, and 3:1 as C1, C2, and C3, respectively. The rats were treated for 30 days. Testicular AGE and RAGE expression and spermatozoa quality were measured. Results: The combination of BST and PSP significantly decreased AGE and RAGE expression in testicular organs and improved spermatozoa quality compared to the normal group. Conclusion: The combination of BST and PSP can be used as future alternatives to improve spermatozoa quality in DM patients.
Lipid is a substance needed for the body as various activities, such as forming a plasma membrane. Lipid will be digested and absorbed through the digestive system in the form of fatty acids and glycerol. Metabolism of lipid into fatty acids and glycerol and the absorption process in the body involves various kinds of enzymes; one of them is Fatty Acid Synthase (FAS). Excess lipid in the body will cause various diseases, such as obesity and cardiovascular diseases. Treatment for excess in lipid level is usually by using synthetic drugs such as statins, but excessive consumption of drug causes various side effects. Single garlic (Allium sativum) (SG) is widely used as an herb that can treat diverse diseases. SG contains organosulfur compounds including Allicin, Alliin, and Ajoene (E-Ajoene and Z-Ajoene). This study aimed to determine the potential of organosulfur compounds in SG as inhibitors of fatty acid synthase (FAS) enzymes which play a role in the process of lipid metabolism. The molecular docking was used to determine the interaction of organosulfur compounds compared with controls (Statins) in the FAS enzyme. Molecular Docking began by taking organosulfur SG compounds and enzymes in PubChem online services and GDP in sequence. The enzyme was sterilized using PyMol software, followed by a docking process, visualization and interaction of ligands on enzyme were carried out using PyRx, PyMol, and LigPlot+ software consecutively. The results showed that organosulfur SG compounds had potential as inhibitor of FAS enzymes. The Allicin, E-Ajoene, and Z-Ajoene had the same binding site with Statins in the FAS enzyme. Based on molecular docking results, it is known that the active compounds found in SG could act as an inhibitor for FAS enzymes which play a role in de novo lipogenesis.
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