2022
DOI: 10.1096/fj.202200640rr
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The function of Foxo1 in spermatogonia development is independent of PI3K/PTEN signaling

Abstract: Spermatogenesis is a highly coordinated process that initiates shortly after birth and continues throughout the lifespan of male animals. Foxo1 is a transcription factor and is involved in many biological processes. It has been reported that the inactivation of Foxo1 in gonocytes during the embryonic stage causes the defects of spermatogenesis. In the present study, we found that the inactivation of Foxo1 in spermatogonia after birth also caused germ cell loss and male infertility. We found that the initiation… Show more

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Cited by 5 publications
(2 citation statements)
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“…Although the function of Foxo1 has been studied in gonocytes 120 , little is known about the roles of Foxk2 and Pou6f1/2 in PGCs. Loss of Foxo1 in embryonic gonocytes leads to defective spermatogenesis in adulthood 120 , and inactivation of Foxo1 in spermatogonia results in germ cell loss and male infertility 121 . FOXO1 activity is also widely involved in regulating metabolic homeostasis, redox balance, cell death, and DNA damage repair 122 .…”
Section: Discussionmentioning
confidence: 99%
“…Although the function of Foxo1 has been studied in gonocytes 120 , little is known about the roles of Foxk2 and Pou6f1/2 in PGCs. Loss of Foxo1 in embryonic gonocytes leads to defective spermatogenesis in adulthood 120 , and inactivation of Foxo1 in spermatogonia results in germ cell loss and male infertility 121 . FOXO1 activity is also widely involved in regulating metabolic homeostasis, redox balance, cell death, and DNA damage repair 122 .…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, this study provides evidence that exosomes secreted by Thy1 spermatogonia play an important role in regulating the proliferation of SSCs. 50 In related studies, we found that spermatogonia have great significance in the study of male infertility diseases, 51 , 52 especially when examining sperm quality, and the number of spermatogonia largely affects the quality of sperm 53 , 54 and testicular development processes. 55 However, the current relevant research is more limited, and the mechanism has not yet been elucidated.…”
Section: Exosomes and Testicular Developmentmentioning
confidence: 99%