Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells
Adriana K. Alexander,
Karina F. Rodriguez,
Yu-Ying Chen
et al.
Abstract:Accurate specification of female and male germ cells during embryonic development is critical for sexual reproduction. Primordial germ cells (PGCs) are the bipotential precursors of mature gametes that commit to an oogenic or spermatogenic fate in response to sex-determining cues from the fetal gonad. The critical processes required for PGCs to integrate and respond to signals from the somatic environment in gonads are not understood. In this study, we developed the first single-nucleus multiomics map of chrom… Show more
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