The emerging role of exosomes in the development of testicular

Li, Chunyang; Liu, Songpo; Dai, Xiaofang; Lan, Dongfeng; Song, Tao; Wang, Xian-Yao; Kong, Qinghong; Tan, Jun; Zhang, Jidong

doi:10.4103/aja2022126

Cited by 3 publications

(1 citation statement)

References 110 publications

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“…Characterization and analysis of the MSC secretome might help to elucidate the precise role of MSCs in tissue regeneration. For example, it has been demonstrated that MSCs release exosomes containing different RNA molecules, such as miRNAs and proteins, that may be key mediators of this process [ 130 , 131 ]. According to a recent study, MSC treatment mitigated busulfan-induced azoospermia in rats by altering the expression of spermatogenesis-related miRNAs and their target genes [ 132 ].…”

Section: Mirnas In Fertility Preservation Strategiesmentioning

confidence: 99%

The Role of microRNA in Spermatogenesis: Is There a Place for Fertility Preservation Innovation?

Klees,

Alexandri,

Demeestere

et al. 2023

IJMS

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Oncological treatments have dramatically improved over the last decade, and as a result, survival rates for cancer patients have also improved. Quality of life, including concerns about fertility, has become a major focus for both oncologists and patients. While oncologic treatments are often highly effective at suppressing neoplastic growth, they are frequently associated with severe gonadotoxicity, leading to infertility. For male patients, the therapeutic option to preserve fertility is semen cryopreservation. In prepubertal patients, immature testicular tissue can be sampled and stored to allow post-cure transplantation of the tissue, immature germ cells, or in vitro spermatogenesis. However, experimental techniques have not yet been proven effective for restoring sperm production for these patients. MicroRNAs (miRNAs) have emerged as promising molecular markers and therapeutic tools in various diseases. These small regulatory RNAs possess the unique characteristic of having multiple gene targets. MiRNA-based therapeutics can, therefore, be used to modulate the expression of different genes involved in signaling pathways dysregulated by changes in the physiological environment (disease, temperature, ex vivo culture, pharmacological agents). This review discusses the possible role of miRNA as an innovative treatment option in male fertility preservation–restoration strategies and describes the diverse applications where these new therapeutic tools could serve as fertility protection agents.

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Section: Mirnas In Fertility Preservation Strategiesmentioning

confidence: 99%

The Role of microRNA in Spermatogenesis: Is There a Place for Fertility Preservation Innovation?

Klees,

Alexandri,

Demeestere

et al. 2023

IJMS

View full text Add to dashboard Cite

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Therapeutic potential of exosomes in spermatogenesis regulation and male infertility

Mohammadi,

Shabani,

Bashiri

et al. 2024

Biology of the Cell

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BackgroundSpermatogenesis is a fundamental process crucial for male reproductive health and fertility. Exosomes, small membranous vesicles released by various cell types, have recently garnered attention for their role in intercellular communication.ObjectiveThis review aims to comprehensively explore the role of exosomes in regulating spermatogenesis, focusing on their involvement in testicular development and cell‐to‐cell communication.MethodsA systematic examination of literature was conducted to gather relevant studies elucidating the biogenesis, composition, and functions of exosomes in the context of spermatogenesis.ResultsExosomes play a pivotal role in orchestrating the complex signaling networks required for proper spermatogenesis. They facilitate the transfer of key regulatory molecules between different cell populations within the testes, including Sertoli cells, Leydig cells, and germ cells.ConclusionThe emerging understanding of exosome‐mediated communication sheds light on novel mechanisms underlying spermatogenesis regulation. Further research in this area holds promise for insights into male reproductive health and potential therapeutic interventions.

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From Germ Cells to Implantation: The Role of Extracellular Vesicles

Fazzio,

Caponnetto,

Ferrara

et al. 2024

JDB

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Extracellular vesicles represent a large heterogeneous class of near and long-distance intercellular communication mediators, released by both prokaryotic and eukaryotic cells. Specifically, the scientific community has shown growing interest in exosomes, which are nano-sized vesicles with an endosomal origin. Not so long ago, the physiological goal of exosome generation was largely unknown and required more investigation; at first, it was hypothesized that exosomes are able to remove excess, reject and unnecessary constituents from cells to preserve cellular homeostasis. However, thanks to recent studies, the central role of exosomes in regulating cellular communication has emerged. Exosomes act as vectors in cell–cell signaling by their cargo, proteins, lipids, and nucleic acids, and influence physiological and pathological processes. The findings on exosomes are widespread in a large spectrum of biomedical applications from diagnosis and prognosis to therapies. In this review, we describe exosome biogenesis and the current methods for their isolation and characterization, emphasizing the role of their cargo in female reproductive processes, from gametogenesis to implantation, and the potential involvement in human female disorders.

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The emerging role of exosomes in the development of testicular

Cited by 3 publications

References 110 publications

The Role of microRNA in Spermatogenesis: Is There a Place for Fertility Preservation Innovation?

The Role of microRNA in Spermatogenesis: Is There a Place for Fertility Preservation Innovation?

Therapeutic potential of exosomes in spermatogenesis regulation and male infertility

From Germ Cells to Implantation: The Role of Extracellular Vesicles

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