The frequency of a concomitant early esophageal cancer in male patients with oral and oropharyngeal cancer. Screening results using lugol dye endoscopy

Ina, Hiroyasu; Shibuya, Hitoshi; Ohashi, Isamu; Kitagawa, Masanobu

doi:10.1002/1097-0142(19940415)73:8<2038::aid-cncr2820730804>3.0.co;2-x

Cited by 98 publications

(66 citation statements)

References 7 publications

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“…It is also necessary to perform endoscopic screening of the esophagus by the Lugol dye method in patients with head and neck cancers before treatment. [17][18][19] In fact, we encountered four cases of early pharyngeal cancers that were successfully treated by endoscopic mucosal resection after surgery for esophageal cancer.…”

Section: Discussionmentioning

confidence: 99%

Multiple Primary Cancers Associated with Esophageal Carcinoma

et al. 2001

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This study was conducted to examine the characteristics of esophageal cancers with primary synchronous or metachronous cancer in another organ. We retrospectively evaluated 744 patients who underwent esophagectomy for esophageal cancers between 1985 and 1998. The patients were divided into two groups according to whether they had multiple primary cancer (MPC) or nonmultiple primary cancer (NPC). Stage I cancer was significantly more frequent among patients with MPC than among those with NPC (P < 0.0001). Among patients with MPC, another primary cancer was found in the head and neck region in 70 (42.4%), in the stomach in 51 (30.9%), and in the colon, lung, breast, and other locations in the remaining patients. Of the 70 patients with another primary cancer in the head and neck region, 32 (45.7%) had pharyngeal cancer. Furthermore, the incidence of intraesophageal multiple cancer in the patients with primary cancer in the head and neck region was significantly higher than that in those whose other primary cancers were gastric cancer or in those with NPC (P = 0.0135. P < 0.0001). The 5-year survival rate of the patients with MPC was 51.28%, which was significantly higher than that of those with NPC (P = 0.019). In conclusion, a better knowledge of the relationships between esophageal carcinoma and cancers in other organs may lead to earlier detection of other primary cancers and improved therapeutic results.

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Section: Discussionmentioning

confidence: 99%

Multiple Primary Cancers Associated with Esophageal Carcinoma

et al. 2001

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“…The reported incidence of esophageal carcinoma associated with multiple primary squamous cell carcinomas of the upper aerodigestive tract in series of head and neck tumor patients varies from 0% to 6.3% (1,2,3,4,5,7,8,9,10,11,12,13,14,17,18,19,22,25) ( Table 2). Furthermore, the incidence of multiple primary tumors in series of patients with squamous cell carcinoma of the esophagus ranged from 3.3% to 12.4% (2,4,9,20,21,24) ( Table 3).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the incidence of multiple primary tumors in series of patients with squamous cell carcinoma of the esophagus ranged from 3.3% to 12.4% (2,4,9,20,21,24) ( Table 3). This wide range in incidence can be partially explained by the site of the initial tumor, type of treatment, ethnic or racial differences, increasing awareness of such tumors, more accurate evaluation and improved survival rates following treatment of the initial primary (1,3,11,20,25) .…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma of the esophagus and multiple primary tumors of the upper aerodigestive tract

Ribeiro

Ivan

Safatle‐Ribeiro

et al. 1999

Arq. Gastroenterol.

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“…High-risk groups for oesophageal squamous cell cancer include male heavy drinkers and smokers, patients with corrosive esophagitis, achalasia or with (previous) head and neck cancer (Makuuchi et al, 1996). The incidence of a second neoplasm in patients who survive HNC is 3 -7% per year (Cooper et al, 1989;Sturgis and Miller, 1995;Ina et al, 1994). Nevertheless, surveillance of HNC patients has thus far not been generally recommended.…”

Section: Discussionmentioning

confidence: 99%

Screening for oesophageal neoplasia in patients with head and neck cancer

et al. 2002

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Due to advanced disease at the time of diagnosis the prognosis of oesophageal cancer is generally poor. As mass screening for oesophageal cancer is neither feasible nor reasonable, high-risk groups should be identified and surveilled. The aim of this study was to define the risk of oesophageal cancer in patients with (previous) head and neck cancer. A total of 148 patients with (previous) head and neck cancer were prospectively screened for oesophageal cancer by video-oesophagoscopy and random oesophageal biopsies. Even in a macroscopically normal looking oesophagus, four biopsy specimens were taken every 3 cm throughout the entire length of the squamous oesophagus. Low-or high-grade squamous cell dysplasia was detected histologically in 10 of the 148 patients (6.8%). All but one dysplasias were diagnosed synchronously with the head and neck cancers. In addition, oesophageal squamous cell carcinoma was diagnosed in 11 of the 148 patients (7.4%). Most invasive cancers (63.6%) occurred metachronously. The risk of squamous cell neoplasia of the oesophagus is high in patients with (previous) head and neck cancer. Surveillance is recommended in this high-risk group.

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The frequency of a concomitant early esophageal cancer in male patients with oral and oropharyngeal cancer. Screening results using lugol dye endoscopy

Cited by 98 publications

References 7 publications

Multiple Primary Cancers Associated with Esophageal Carcinoma

Multiple Primary Cancers Associated with Esophageal Carcinoma

Squamous cell carcinoma of the esophagus and multiple primary tumors of the upper aerodigestive tract

Screening for oesophageal neoplasia in patients with head and neck cancer

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