Screening for oesophageal neoplasia in patients with head and neck cancer

Scherübl, Hans; Lampe, B; Faiss, Siegbert; Däubler, P; Bohlmann, P.; Plath, T.; Foss, Hans‐Dieter; Scherer, Hans; Strunz, Anke M.; Hoffmeister, Bodo; Stein, Harald; Zeitz, Martin; Riecken, Ernst–Otto

doi:10.1038/sj.bjc.6600018

Cited by 47 publications

(28 citation statements)

References 25 publications

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“…Even in those areas, however, surveillance and chemoprevention may be warranted in high-risk groups. High-risk groups for ESCC include male subjects with heavy drinking or smoking habits, patients with (previous) HNC, patients with corrosive oesophagitis or carriers of the gene for autosomal dominant transmission of tylosis (Makuuchi et al, 1996;Scherübl et al, 2002b). The overall prognosis of oesophageal cancer is very poor due to advanced disease at diagnosis and aggressive tumour biology.…”

Section: Discussionmentioning

confidence: 99%

“…All observers agreed on the diagnosis of cancer or dysplasia in the patients described here. Two out of three was considered a consensus for specimens without unanimous dysplasia grading (Scherübl et al, 2002b). Low-and high-grade dysplasia (synonym: intraepithelial neoplasia) was defined as unequivocal neoplastic transformation according to previously published criteria (Lewin and Appelman, 1995).…”

Section: Patients and Tissue Samplesmentioning

confidence: 99%

“…Oesophageal carcinogenesis and tumour progression require more detailed elucidation, particularly in high-risk groups. Patients with (previous) head and neck cancer (HNC) are a clinically important high-risk group with an 11.8 -16.6% risk of ESCC or intraepithelial neoplasia (Makuuchi et al, 1996;Tincani et al, 2000;Scherübl et al, 2002b). Thus, effective chemoprevention of oesophageal neoplasia is most desirable in these patients.…”

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Oesophageal squamous cell neoplasia in head and neck cancer patients: upregulation of COX-2 during carcinogenesis

et al. 2003

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Patients with (previous) head and neck cancer (HNC) are at high risk for developing second squamous cell cancer of the oesophagus. The role of cyclooxygenase-2 (COX-2) in oesophageal squamous carcinogenesis has not yet been investigated in this high-risk group. Therefore, this study examined COX-2 mRNA and protein expression in oesophageal biopsies and resected tissues of 44 HNC patients. The evaluation covered 55 oesophageal tissue samples (18 invasive oesophageal squamous cell cancers, four high-and eight low-grade dysplasias, 25 normal squamous epithelia) from the 44 patients. mRNA levels of COX-2 were measured by real-time PCR using a LightCycler. COX-2 protein expression was studied immunohistochemically and graded by a staining score. COX-2 mRNA was detected in all samples, and its levels correlated positively with the immunohistochemical staining score (Po0.05). COX-2 expression was upregulated during oesophageal squamous carcinogenesis in HNC patients, that is COX-2 expression increased significantly from normal oesophageal squamous epithelium to low-and high-grade dysplasia and finally to invasive squamous cell cancer (Po0.001). Our findings suggest that COX-2 upregulation contributes to oesophageal squamous carcinogenesis in HNC patients. Prospective studies are needed to evaluate the chemopreventive potential of COX-2 inhibitors in this high-risk group.

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Section: Discussionmentioning

confidence: 99%

Section: Patients and Tissue Samplesmentioning

confidence: 99%

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Oesophageal squamous cell neoplasia in head and neck cancer patients: upregulation of COX-2 during carcinogenesis

et al. 2003

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“…2 In patients with head and neck squamous cell carcinoma (HNSCC), esophageal cancer is the most common synchronous cancer. [3][4][5][6] In Korea, esophageal cancer is detected in 5.0∼7.1% of patients with HNSCC 4,7 and occurs most frequently in HNSCC patients with tumors of the hypopharynx. 7,8 Related risk factors for esophageal cancer include a positive history of smoking.…”

Section: Introductionmentioning

confidence: 99%

Incidence of Gastric Cancer in Patients with Laryngeal Cancer

Seo

Kim

Park

et al. 2017

Korean J Helicobacter Up Gastrointest Res

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Background/Aims: Gastric cancer (GC) is the second most common cancer in Korea and the most common in men in the south of the country. We investigated the incidence of synchronous GC in patients with head and neck squamous cell carcinoma (HNSCC) in the southern part of Korea. Materials and Methods: We retrospectively reviewed the medical records of HNSCC patients treated between 2011 and 2014. In patients with synchronous GC, evaluation included a history of smoking and alcohol consumption, endoscopic findings, Campylobacter-like organism (CLO) test, and immunohistochemical analysis of preserved HNSCC tissues. Results: Analysis of the records of 153 HNSCC patients revealed tumors of the larynx in 56 patients (36.6%), of the pharynx in 74 patients (48.4%), and tumors at other locations in 23 patients (15.0%). The mean age of patients was 66.0 years, and the men:women ratio was 8:1. Synchronous cancers were detected in 12 patients. We observed esophageal squamous cell carcinoma (SCC) in five patients (3.3%), and gastric adenocarcinoma in seven patients (4.6%). Synchronous GC was detected in patients with laryngeal SCC. All cases of GC were classified as early GC. Conclusions: Synchronous GC was as frequent as esophageal SCC in patients with HNSCC, and all cases of GC were observed to be early stage cancers in this study. Thorough endoscopic examination should be performed in patients with laryngeal cancer to de-

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“…Achalasia, Plummer-Vinson syndrome and scleroderma all increase the risk of oesophageal squamous dysplasia by oesophageal stasis [3]. An association between oesophageal carcinoma with another head and neck cancer has been well described, often secondary to smoking as the carcinogen [8]. A further disease that increases the risk of head and neck cancers is Fanconi anaemia representing a rare inherited genetic defect [9,10].…”

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confidence: 99%