The Exercise-Induced Increase in Plasma Levels of Endothelin-1 is Enhanced in Patients with Atherosclerotic Coronary Artery Disease. Modulation by Pentaerithrityltetranitrat (PETN)

Exhaustive exercise-induced tissue hypoxia does not change endothelin and big endothelin plasma levels in normal volunteers

“…The absence of an effect of exercise on ET-1 release in normal subjects is in agreement with previous studies. 3,12,13,15 At variance with our results, however, Rocker et al 9 showed that plasma endothelin levels increased by about 50% immediately after short-term exercise at maximal capacity. Maeda et al 8 reported that plasma ET-1 levels increased in parallel with exercise intensity with a peak at 30 min after termination of exercise.…”

“…Several investigators reported that with prolonged exercise ET-1 levels were markedly increased in healthy volunteers without 8 -10 or with dehydration 11 as well as in patients with coronary artery disease. 12,13 The increase was found to be augmented by alveolar hypoxia in healthy subjects.…”

“…14 Others, however, reported no change during exercise compared to resting values in normal volunteers under normoxic 3,12,13,15 or hypobaric conditions, 16 or in patients with coronary heart disease 17 or congestive heart failure. 4,18 These discrepancies may partly be attributable to different exercise protocols, in particular with regard to the duration and the workload increments (ie, aerobic v anaerobic conditions).…”

Endocrine response to exercise in young and old horses

“…These data suggest that while ageing may alter the control of cardiovascular function in the exercising horse, it does not produce the pronounced alterations that one would see in an exercising individual with a compromised cardiovascular system. Such is the case in studies of age-matched individuals with heart failure or hypertension (Seals and Reiling 1991;Letizia et al 1995;Predel et al 1995). The observed differences in PRA and the plasma concentrations of the A", AVP, and ALDO measured in the present study may, however, reflect differences in sensitivity in the regulation of blood pressure and blood flow during exertion.…”

Correlations of the renin‐angiotensin‐system (RAS) gene polymorphisms with cardiac growth factors endothelin‐1 and angiotensin II in high performance athletes

“…AII and ET-1 plasma concentrations were determined by radioimmunoassay (RIA) techniques as has been previously described (8,24).…”