The Evaluation of Neutrophil to Lymphocyte ratio and mean platelet volume in patients with active and inactive thyroid orbitopathy

Litwińczuk

et al. 2020

JCM

Graves’ orbitopathy (GO) is an autoimmune disease with a chronic inflammatory background. Smoking behavior is the main environmental factor responsible for the transition of this major extra thyroidal manifestation of Graves’ disease (GD) from the subclinical to the overt form. Complete blood count-derived parameters are suggested to be novel inflammatory indices. The aim of this retrospective study was to investigate the association between neutrophil-to-lymphocyte (NLR), monocyte-to-lymphocyte (MLR), and platelet-to-lymphocyte ratios (PLR) with selected clinical parameters and smoking status in 406 GD patients with (n = 168) and without GO (n = 238). The control group consisted of 100 healthy individuals. The activity of GO was graded according to Clinical Activity Score. Significantly higher white blood cells (WBC), neutrophil, and NLR (p < 0.05) values were observed in GD patients with GO compared with those without GO. PLR values were significantly higher in GO patients than in the controls. WBC (6.81 ± 1.56 vs. 5.70 ± 1.23) and neutrophils (3.89 ± 1.06 vs. 3.15 ± 0.95) count was higher in active GO patients than in those with inactive GO. Positive correlation (p < 0.05) between CAS score and WBC, neutrophil and monocyte count, and NLR was found. Smoking was associated with higher WBC (p = 0.040), neutrophil (p = 0.049), PLR (p = 0.032) values. Multivariate analysis revealed that WBC, NLR may be risk factors for GO development. WBC, neutrophil, NLR and PLR values seem to be useful tools in the assessment of inflammation in GD.

Section: Discussionsupporting

confidence: 76%

Section: Discussionsupporting

confidence: 69%

See 1 more Smart Citation

Neutrophil-to-Lymphocyte, Monocyte-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Relation to Clinical Parameters and Smoking Status in Patients with Graves’ Orbitopathy—Novel Insight into Old Tests

Litwińczuk

et al. 2020

JCM

“…In addition to CV disease, these hematological markers were also studied in many acute or chronic diseases for the prognosis, pathophysiological mechanisms, risk stratification, and optimal management. 6 –8 Red cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR), monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHDLr), mean platelet volume (MPV), mean platelet volume-to-lymphocyte ratio (MPVLr), and platelet to lymphocyte ratio (PLR) are the most studied hematological indices in CV diseases. Each marker, on its own, has been shown to be associated with in-hospital and/or long-term mortality (LTM) in patients with STEMI.…”

Section: Introductionmentioning

confidence: 99%

Comparing the Prognostic Value of Hematological Indices in Patients With ST Segment Elevation Myocardial Infarction: “A Head to Head” Analysis

et al. 2020

Although there are reviews and meta-analyses focusing on hematological indices for risk prediction of mortality in patients with ST segment elevation myocardial infarction (STEMI), there are not enough data with respect to direct to head-to-head comparison of their predictive values. We aimed to investigate which hematological indices have the most discriminatory capability for prediction of in-hospital and long-term mortality in a large STEMI cohort. We analyzed the data of 1186 patients with STEMI. In-hospital and long-term all-cause mortality was defined as the primary end point of the study. In-hospital mortality rate was 8.6% and long-term mortality rate 9.0%. Although the neutrophil to lymphocyte ratio (NLR) and age were found to be independent predictors of in-hospital mortality in the multivariate regression analyses; Cox regression analysis revealed that age, ejection fraction, red cell distribution width (RDW), and monocyte to high-density lipoprotein ratio (MHDLr) were independently associated with long-term mortality. Neutrophil to lymphocyte ratio had the highest area under curve value in the receiver operating characteristic curve analyses for prediction of in-hospital mortality. In conclusion, while NLR may be used for prediction of in-hospital mortality, RDW and MHDLr ratio are better hematological indices for long-term mortality prediction after STEMI than other most common indices.

“…There is a significant independent relationship between inflammation markers such as leucocyte count, neutrophil count, CRP, interleukin, and TNF-α. [ 9 , 10 ] In addition, neutrophil-to-lymphocyte ratio (NLR) is considered to be a marker of subclinical inflammation which is associated with morbidity and mortality in diabetic patients. [ 11 , 12 ]…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Epicardial Fat Tissue Thickness and CRP And Neutrophil Lymphocyte Ratio In Metabolic Syndrome Patients Over 65 Years

et al. 2021

Objective: There are no data evaluating the association of neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) with epicardial fat tissue thickness (EFTT) in elderly metabolic syndrome (MS) patients. In this study, we aimed to investigate the relationship of EFTT with CRP and NLR in patients with MS over 65 years. Methods: A cross-sectional study was performed. Fifty patients (patient group) with MS and 25 subjects (control group) without MS were allocated in the study. All parameters were compared in patient and control groups. The correlations between NLR, CRP, and EFTT were evaluated. Results: White blood cell and neutrophil levels were higher in MS group ( p =0.020 and p =0.019, respectively). Both transverse and longitudinal EFTT were increased in MS patients ( p <0.001). There was a significant correlation between the EFTT and NLR but not with CRP in the MS group (r=0.4, p =0.003). Conclusion: Our study showed that both longitudinal and transverse EFTT are associated with NLR in patients older than 65 years with MS. In geriatric MS patients, higher NLR level may be an indicator of increased visceral fat around the myocardium.