Comparing the Prognostic Value of Hematological Indices in Patients With ST Segment Elevation Myocardial Infarction: “A Head to Head” Analysis

Sığırcı, Serhat; Ser, Özgür Selim; Keskin, Kudret; Yıldız, Süleyman Sezai; Gürdal, Ahmet; Kılıçkesmez, Kadriye Orta

doi:10.1177/0003319720977754

Cited by 7 publications

(6 citation statements)

References 38 publications

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“…It has previously been reported that high RDW is associated with increased incidence of CV diseases in the general population and that RDW is associated with poor prognosis in patients with established CV disease. 7,8,20,21 The present study demonstrated that RDW is significantly associated with coronary atherosclerosis, as measured by CACS. This association remained significant after adjustment for CV risk factors.…”

Section: Discussionsupporting

confidence: 60%

Associations of Red Cell Distribution Width With Coronary Artery Calcium in the General Population

et al. 2021

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Red cell distribution width (RDW) is a measure of the variability of erythrocyte volumes. RDW has been associated with incidence of cardiovascular diseases. However, the underlying mechanisms for the increased cardiovascular risk are still unclear. This study aimed to examine associations of RDW and coronary atherosclerosis in the general population. Computed tomography was performed and RDW was measured in fresh blood from 5772 subjects (aged 50–64 years) from the Swedish CArdioPulmonary bioImage Study (SCAPIS). Multinomial logistic regression was conducted to examine the associations between RDW and coronary artery calcium score (CACS). A total of 3902 (67.6%) individuals had low CACS (≤10), 18.6% had moderate CACS (>10 and ≤100) and 13.8% had high CACS (>100). The proportion with high CACS was 11.7%, 12.7%, 13.7% and 18.3%, respectively, in quartile 1–4 of RDW. After controlling for traditional risk factors, there were significant associations between RDW and high CACS: odds ratio = 1.51, 95% confidence interval: 1.18–1.94, and P = .001, for 4th vs 1st quartile of RDW. Elevated RDW is associated with coronary artery calcification in the middle-aged general population. RDW could be a reproducible and easily assessable biomarker of coronary calcification and cardiovascular risk.

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Section: Discussionsupporting

confidence: 60%

Associations of Red Cell Distribution Width With Coronary Artery Calcium in the General Population

et al. 2021

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“…14 Several studies reported that NLR was associated not only with CAD risk but also with CAD severity. 7,8,24,25 NLR was found to be a predictor of short-term 26,27 as well as long-term 28,29 prognosis in patients with myocardial infarction. In the overall population as well as in males of the present study, patients with CAD had higher WBC and neutrophil counts as well as NLR compared with non-CAD patients.…”

Section: Discussionmentioning

confidence: 91%

Sex Difference in the Association Between Neutrophil to Lymphocyte Ratio and Severity of Coronary Artery Disease

Qin

Zhang

et al. 2022

Angiology

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The neutrophil to lymphocyte ratio (NLR) is a predictor of cardiovascular risk. However, little was known about the influence of sex in this relationship. The present study was designed to evaluate the association between NLR and coronary artery disease (CAD) risk and severity in males and females. A total of 810 patients (478 males and 332 females) who had undergone coronary angiography at the Beijing Chaoyang Hospital were enrolled. CAD severity was evaluated using the Gensini and SYNTAX scores. For males, the NLR was higher in CAD patients than that in non-CAD patients (all P < .001). But there was no significant difference in NLR between female CAD and non-CAD patients ( P = .222). The NLR correlated with the Gensini and SYNTAX scores in male CAD patients (both P < .001), but this correlation was not found in female counterparts (both P > .10). Logistic regression analyses and receiver operator characteristic curve (ROC) analyses showed that the NLR was an independent risk factor and a predictor of CAD in males (both P < .01) but not in females (both P > .10). In conclusion, the NLR was closely related to the presence and severity of CAD in males but not in females.

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“…Notably, there are findings that high MHR is not associated with long-term outcomes in patients with CHD. Correlative studies have shown that a high MHR did not significantly increase case fatality [31]. This statistical result had a wide range of CIs and may be related to the small sample size for inclusion.…”

Section: Discussionmentioning

confidence: 96%

Association between monocyte to high-density lipoprotein ratio and coronary heart disease in US adults in the National Health and Nutrition Examination Surveys 2009–2018

Yan

Sha²,

Wang³

et al. 2022

Coronary Artery Disease

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Background Monocyte to high-density lipoprotein ratio (MHR) is associated with coronary heart disease (CHD) events. The purpose of this study was to analyze the correlation between MHR and CHD in American adults from 2009 to 2018 in the National Health and Nutrition Examination Surveys (NHANES) database. Methods A total of 25 862 persons in the NHANES from 2009 to 2018 were included in the cross-sectional analysis. The independent variable was MHR and the outcome variable was CHD. MHR was obtained by dividing the number of monocytes by the high-density lipoprotein concentration, and whether it is CHD is obtained through a questionnaire. Univariate analysis, stratified analysis, and a multivariate linear regression model were used to study the correlation between MHR and CHD. Results In each multivariate linear regression model, MHR was positively correlated with CHD, and this positive correlation was stable in both men and women [man odds ratio (OR): 1.54; 95% confidence interval (CI), 1.17–2.03; woman OR: 2.21; 95% CI, 1.40–3.50]. Our results show that the association between MHR and CHD was significant until MHR was less than 0.6 (OR: 7.2; 95% CI, 4.0–13.0); however, in cases where MHR was greater than 0.6, the results were negative but not significantly different (OR: 0.6; 95% CI, 0.3–1.2). Conclusion MHR has a clear association with CHD. Our prediction model and validation model show that MHR is highly predictive and robust as a predictor of CHD, therefore it can play an important role in the prediction of CHD.

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Comparing the Prognostic Value of Hematological Indices in Patients With ST Segment Elevation Myocardial Infarction: “A Head to Head” Analysis

Cited by 7 publications

References 38 publications

Associations of Red Cell Distribution Width With Coronary Artery Calcium in the General Population

Associations of Red Cell Distribution Width With Coronary Artery Calcium in the General Population

Sex Difference in the Association Between Neutrophil to Lymphocyte Ratio and Severity of Coronary Artery Disease

Association between monocyte to high-density lipoprotein ratio and coronary heart disease in US adults in the National Health and Nutrition Examination Surveys 2009–2018

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