The Endothelium of Clear Corneal Transplants

Bourne, William M.; Kaufman, Herbert E.

doi:10.1001/archopht.1976.03910040504008

Cited by 85 publications

(37 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the first study the endothelia in the centers of the donor corneas and of the grafts were photographed through a modified clinical specular microscope (Bourne & Kaufman 1976). Details of the photography and cell counting were given in the earlier papers (Ruusuvaara 1979(Ruusuvaara ,1980a.…”

Section: Methodssupporting

confidence: 42%

“…In our cases the corneal thickness was within the normal limits and in most other reports the graft thickness has been normal, supporting the view that, even with considerable cell loss, the graft endothelium maintains good function (Bourne & Kaufman 1976, Laing et al 1976, Sato 1978, Linn et al 1981, Abbott et al 1983). However, with a particularly low cell count, the endothelial cell permeability coefficient may be pathological (Beneyto et al 1996), meaning impending decompensation.…”

Section: Discussionmentioning

confidence: 45%

See 1 more Smart Citation

Follow‐up study of human corneal endothelial cells, photographed in vivo before enucleation and 20 years later in grafts

Vasara

Setälä

Ruusuvaara

1999

Acta Ophthalmologica Scandinavica

View full text Add to dashboard Cite

ABSTRACT.Purpose: To evaluate the long-term (20-year) survival of transplanted human corneal endothelial cells. Methods: The donor endothelium had been photographed 20 years ago with a specular microscope both before enucleation in the melanomatous eye and in situ after keratoplasty. The same donor endothelial cells were now photographed again 20 years later with a modern specular microscope to ascertain the morphology and cell density of the grafts. Results: In the earlier study the mean postoperative endothelial cell density was 1357∫543 cells/mm 2 , the average cell loss 11 months postoperatively being 48.2%; 20.5 years postoperatively the cell loss was 62.9% of the preoperative cell count. In our well-documented patient population the endothelial cell loss during the last 19 years had been only 14.7%, which amounts to a cell loss of less than 1% per year. Conclusion: In transplanted corneas, the main endothelial cell loss seems to take place during the first 1-2 postoperative years.

show abstract

Section: Methodssupporting

confidence: 42%

Section: Discussionmentioning

confidence: 45%

Follow‐up study of human corneal endothelial cells, photographed in vivo before enucleation and 20 years later in grafts

Vasara

Setälä

Ruusuvaara

1999

Acta Ophthalmologica Scandinavica

View full text Add to dashboard Cite

show abstract

“…Although overall corneal endothelial functions can be estimated by measuring corneal thickness [27], little pathophysiological information is gained by simply measuring corneal thickness [28, 29, 30]. With the improvement in the technique of drug delivery, fluorophotometry is now a useful clinical tool to investigate pathophysiological changes, especially in the barrier functions of the anterior segment [31, 32, 33, 34, 35, 36].…”

Section: Introductionsupporting

confidence: 42%

Effects of Contact Lenses on Corneal Endothelium – A Morphological and Functional Study

Chang

Lin

2001

Ophthalmologica

View full text Add to dashboard Cite

Purpose: To study the corneal endothelial morphological changes and endothelial barrier function in contact lens wearers. Methods: Specular microscopy and anterior segment fluorophotometry were performed on 116 controls (group 1) and 76 daily wear soft contact lens wearers. Group 2 patients (n = 34) had been wearing contact lenses for less than 5 years and group 3 (n = 42) for more than 5 years. The relationship of corneal thickness, endothelial cell density, hexagonal cell percentage, coefficient of variation in cell area, corneal autofluorescence and corneal endothelial permeability to the contact lens wear duration was studied. Results: The average corneal thickness of contact lens wearers did not differ significantly from controls (0.533 ± 0.031, 0.538 ± 0.044, 0.532 ± 0.031 mm for groups 1, 2 and 3, respectively; p = 0.89). However, there was a significant tendency toward corneal thinning with a longer history of contact lens wear (r = –0.31, p = 0.002 in groups 2 and 3). The percentage of hexagonal cells decreased with both increasing hours of contact lens wear per day (r = –0.36, p < 0.001) and the duration of contact lens wear in years (r = –0.33, p < 0.001), but there was no significant change in endothelial cell density in contact lens wearers. The coefficient of variation in cell size correlated more closely with increased hours of contact lens wear per day (r = 0.35, p = 0.002) than with the duration of contact lens wear in years (r = 0.12; p = 0.31). In the functional study, corneal autofluorescence increased in contact lens wearers (5.13 ± 0.71 ng/ml in group 1, 6.45 ± 2.03 ng/ml in group 2 and 7.21 ± 1.51 ng/ml in group 3, respectively, p < 0.001) and the mean endothelial permeability decreased in contact lens wearers (3.89 ± 0.95 ×10^–4/cm in group 1, 2.71 ± 0.73 × 10^–4/cm in group 2 and 2.95 ± 0.91 × 10^–4/cm in group 3, respectively, p = 0.003). Conclusions: Daily wear soft contact lenses caused morphological changes in the corneal endothelium. With an increasing span of contact lens wear, there was a significantly increased variation in cell size, a decreased hexagonal cell percentage, an evident intercellular dark area and rosette formation. The corneal autofluorescence increased and the overall endothelial permeability decreased as a consequence of contact lens wear. Contact lens wear also caused corneal thinning, and the cornea became thinner with increasing duration of contact lens wear.

show abstract

“…In contrast to cataract surgery, endothelial cell loss after PK is known to be an ongoing process even years after surgery. Endothelial cell loss is higher in the early time course after surgery and decreases 3-5 years after surgery [6,7,8,9,17].…”

Section: Introductionmentioning

confidence: 46%

Predictive donor factors for chronic endothelial cell loss after nonmechanical penetrating keratoplasty in a regression model

Langenbucher¹,

Nguyen²,

Seitz³

2003

Graefe's Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

show abstract

The Endothelium of Clear Corneal Transplants

Cited by 85 publications

References 10 publications

Follow‐up study of human corneal endothelial cells, photographed in vivo before enucleation and 20 years later in grafts

Follow‐up study of human corneal endothelial cells, photographed in vivo before enucleation and 20 years later in grafts

Effects of Contact Lenses on Corneal Endothelium – A Morphological and Functional Study

Predictive donor factors for chronic endothelial cell loss after nonmechanical penetrating keratoplasty in a regression model

Contact Info

Product

Resources

About