Predictive donor factors for chronic endothelial cell loss after nonmechanical penetrating keratoplasty in a regression model

Langenbucher, Achim; Nguyen, Nhung X.; Seitz, Berthold

doi:10.1007/s00417-003-0701-1

Cited by 29 publications

(28 citation statements)

References 34 publications

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“…Especially when the host endothelium is insufficient, a relatively large graft delivers more endothelial cells and may thus provide better protection for the central graft. Langenbucher et al [15] demonstrated that annual endothelial cell loss correlated significantly inversely with the trephination diameter in a bullous keratopathy group after nonmechanical PKP. In our patients with mechanical PKP, an inverse correlation was also observed between endothelial cell loss and trephine diameter at all follow-up times >3 months (table 3).…”

Section: Discussionmentioning

confidence: 99%

Corneal Endothelial Cell Loss after Penetrating Keratoplasty in Relation to Preoperative Recipient Endothelial Cell Density

Chung

Kim²,

Kim³

2009

Ophthalmologica

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Aim: Our purpose was to assess recipient endothelial cell density and trephination diameter as predictive factors for corneal endothelial cell density after penetrating keratoplasty (PKP). Methods: Forty-eight eyes showing keratoconus (group I, with sufficient recipient endothelial cell density) and 42 eyes demonstrating bullous keratopathy or Fuchs’ dystrophy (group II, with insufficient recipient endothelial cell density) were included in this retrospective study. The endothelial cell density after PKP was assessed over 2 years. Results: Chronic endothelial cell loss was significantly higher in group II than in group I patients at all follow-up times >3 months (p < 0.05). In group II patients, an inverse correlation between endothelial cell loss and trephine diameter was observed. Conclusion: This study shows that recipient endothelial cell density is a risk factor for increased endothelial cell loss following PKP. In patients with insufficient endothelial cell density, a large trephine size could reduce chronic endothelial cell loss.

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Section: Discussionmentioning

confidence: 99%

Corneal Endothelial Cell Loss after Penetrating Keratoplasty in Relation to Preoperative Recipient Endothelial Cell Density

Chung

Kim²,

Kim³

2009

Ophthalmologica

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“…Langenbucher et al [13] reported no significant association between the annual endothelial cell loss and the donor age as well as postmortem interval. However, the storage time had a statistically significant correlation with the annual endothelial cell loss.…”

Section: Effect Of Donor and Eye-bank Variables On Clinical Outcomesmentioning

confidence: 98%

“…When indicated for optical purposes, PK surgeons prefer transplanting donor cornea tissues with quality ranging from good to very good to excellent to provide adequate endothelial cells for a lifelong period. The acceptable conditions for PK donors are donor age varying from 1 to 96 years [9][10][11][12][13][14][15][16], endothelial cell density between 2000 and ≥ 3000 cells/mm In contrast to penetrating keratoplasty, donors with quality ranging from fair to excellent are employed for DALK [20,21]. Furthermore, long-term preserved donor tissues completely devoid of cells are also transplanted [22][23][24][25].…”

Section: Type and Quality Of Donors Used For Pk And Dalkmentioning

confidence: 99%

Donor Graft Quality Used for Penetrating Keratoplasty and Deep Anterior Lamellar Keratoplasty

Feizi¹

2016

Advances in Eye Surgery

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Deep anterior lamellar keratoplasty (DALK) has been recently introduced as an alternative to penetrating keratoplasty (PK) for corneal pathologies not involving corneal endothelium. DALK does not rely on donor endothelium and requires less rigid criteria for donor corneal tissue quality. Therefore, it provides a greater availability of donor corneas that do not need perfectly healthy endothelium and high endothelial cell density to be suitable for PK. Furthermore, as lamellar corneal surgery expands the potential use of acellular corneal tissue, long-term preservation techniques are being revisited as a way to increase availability of corneal tissue to alleviate constraints of availability, cost, storage, and transportation in many countries. The recent alterations in the technique of corneal transplantation and hence the type of donor cornea tissues used for each technique, may require eye banks and corneal surgeons to reassess their selection criteria but it is important for any changes to be evidence-based. The purpose of this chapter, therefore, is to present an updated analysis on the type and quality of donor corneas used for PK and DALK, to evaluate the impact of donor and eye bank variables on the suitability of corneas for transplantation and then go on to determine whether any of these donor factors affect clinical outcomes, complications, and graft survivals.

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“…Nestes casos, existe a necessidade eventual de cirurgias trí-plices de fixação escleral ou iriana da LIO nos afácicos ou com LIOs descentradas, colocação de tubos para controle da pressão intra-ocular, reorganização do segmento anterior por terem antecedentes de cirurgias de cataratas complicadas. Isto faz com que o tempo cirúrgico e a reação inflamatória no pós-operatório seja maior, contribuindo para maior perda de células endoteliais e pior prognóstico visual (36)(37)(38) . Tem-se avaliado a ceratoplastia lamelar posterior (DSEK e DLEK) para casos de doenças endoteliais da córnea.…”

Section: Tratamentounclassified

Ceratopatia bolhosa: etiopatogênese e tratamento

Gonçalves¹,

Campos²,

Paris³

et al. 2008

Arq. Bras. Oftalmol.

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Predictive donor factors for chronic endothelial cell loss after nonmechanical penetrating keratoplasty in a regression model

Cited by 29 publications

References 34 publications

Corneal Endothelial Cell Loss after Penetrating Keratoplasty in Relation to Preoperative Recipient Endothelial Cell Density

Corneal Endothelial Cell Loss after Penetrating Keratoplasty in Relation to Preoperative Recipient Endothelial Cell Density

Donor Graft Quality Used for Penetrating Keratoplasty and Deep Anterior Lamellar Keratoplasty

Ceratopatia bolhosa: etiopatogênese e tratamento

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