The efficacy of ginseng supplementation on plasma lipid concentration in adults: A systematic review and meta-analysis

Supplementation with Ginseng, Lilii Bulbus, and Poria induces alterations in the serum metabolic profile of healthy adults

“…24–27 Several mechanisms have been reported to explain Ginseng's anti-hyperlipidemic effects in humans, including its anti-inflammatory and antioxidant activities and its ability to reduce liver cholesterol and TG levels through activating AMP-activated protein kinase (AMPK). 8 Based on the above evidence, we speculate that the drug decreases saturated fatty acids. PON1 is an HDL-associated protein that can hydrolyze oxidized LDL-cholesterol, perhaps protecting against atherosclerosis.…”

“…Food & Function through activating AMP-activated protein kinase (AMPK). 8 Based on the above evidence, we speculate that the drug decreases saturated fatty acids. PON1 is an HDL-associated protein that can hydrolyze oxidized LDL-cholesterol, perhaps protecting against atherosclerosis.…”

“…Ginseng, of which ginsenosides are active ingredients, has a number of pharmacological activities, including antioxidant, 4,5 anti-inflammatory, 6,7 and lipid reduction. 7,8 Lilii Bulbus is a traditional Chinese herb with multiple health benefits. It has been found in pharmacological research to inhibit inflammatory responses 9,10 and to have antioxidant 11,12 and free radical scavenging 11 activities attributed to its active components.…”

The Efficacy of Ginseng (Panax) on Human Prediabetes and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

“…The higher the dose, the greater the effect of ginseng supplementation on lowering HDL-C. We found a disparity in findings obtained from previous meta-analyses investigating the efficacy of ginseng administration on lipid profile parameters. One suggested no lipid-lowering effects of ginseng consumption from three previous meta-analyses conducted on healthy and unhealthy individuals [36], while others indicated significant exerted effects of ginseng intake [32,34]. Additionally, a previous meta-analysis that investigated ginseng supplementation in patients with T2DM demonstrated a significant effect of ginseng supplementation on serum TC, TG, and LDL-C levels [63].…”

“…Some studies documented improved levels of anthropometric indices [1], glucose-related markers [26,27], lipid profile components [5], blood pressure [28], and inflammatory markers [21] following ginseng consumption, whereas others indicated null effects [12,22,29,30]. Furthermore, previous systematic reviews and meta-analyses of randomized controlled trials (RCTs) on ginseng supplementation have only covered certain cardiometabolic indicators in various health conditions [19,[31][32][33][34][35][36]. Besides, there was no prior systematic review and meta-analysis investigating the effects of ginseng supplementation on cardiometabolic indicators exclusively in individuals with prediabetes and T2DM.…”