A comprehensive review on phytochemicals for fatty liver: are they potential adjuvants?

Moinho, Taís Menezes do; Matos, Sandro Leão; Carvalho, Carla Roberta de Oliveira

doi:10.1007/s00109-021-02170-3

Cited by 6 publications

(3 citation statements)

References 166 publications

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“…In the recent era of research and development, the natural phytochemicals are also playing very important role for the treatment of NAFLD. Epidemiological evidence recommends that a healthy dietary habits with cumulative intake of several plant-based natural phytochemicals, i.e., spirulina, berberine, oleuropein, garlic, curcumin, resveratrol, coffee, ginseng, glycyrrhizin, cocoa powder, bromelain, and epigallocatechin-3-gallate could lower the risk of NAFLD [ 149 , 150 ], and researchers are working to develop the phytochemicals based on conventional, safe, and effective dose formulations via the clinical studies. Some of the important bioactive components of antiobesity preclinical screening details are discussed in Table 4 .…”

Section: Therapeutic Application Of Phytochemicals In Obesitymentioning

confidence: 99%

Biogenic Phytochemicals Modulating Obesity: From Molecular Mechanism to Preventive and Therapeutic Approaches

Kumar

Singh

Lakhawat

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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The incidence of obesity and over bodyweight is emerging as a major health concern. Obesity is a complex metabolic disease with multiple pathophysiological clinical conditions as comorbidities are associated with obesity such as diabetes, hypertension, cardiovascular disorders, sleep apnea, osteoarthritis, some cancers, and inflammation-based clinical conditions. In obese individuals, adipocyte cells increased the expression of leptin, angiotensin, adipocytokines, plasminogen activators, and C-reactive protein. Currently, options for treatment and lifestyle behaviors interventions are limited, and keeping a healthy lifestyle is challenging. Various types of phytochemicals have been investigated for antiobesity potential. Here, we discuss pathophysiology and signaling pathways in obesity, epigenetic regulations, regulatory mechanism, functional ingredients in natural antiobesity products, and therapeutic application of phytochemicals in obesity.

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Section: Therapeutic Application Of Phytochemicals In Obesitymentioning

confidence: 99%

Biogenic Phytochemicals Modulating Obesity: From Molecular Mechanism to Preventive and Therapeutic Approaches

Kumar

Singh

Lakhawat

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Due to its complex etiology reflecting multiple interactions between environmental and genetic factors, there is no official approved pharmacological therapy available for NAFLD currently except for weight reduction to meet the great demand. 2 Traditional Chinese medicine (TCM) has undergone thousands of years of development and has also formed a unique theoretical system that acknowledged NALFD is related to deficiency and depression of Qi. The practice of TCM has been guided by the principle of "observing its pulse patterns, knowing where to go wrong, and treating according to the symptoms".…”

Section: Introductionmentioning

confidence: 99%

UPLC-Q-TOF-MS Analysis of Chemical Constituents of the Kadsura coccinea Extract with Effect of Attenuating Lipid Accumulation in Vitro

Gu,

Liu,

Wang

et al. 2024

Natural Product Communications

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Objective/Background: This study aims to explore the Kadsura coccinea extract (KCE)'s effect on lipid accumulation in vitro and its chemical components characterizations, aiming at developing a new alternative plant medicinal resource to fight against non-alcoholic fatty liver disease (NAFLD). Methods: After toxicological evaluation of KCE on HepG2 cells, Oil red O staining model and intracellular TGs quantification kit were used to examine the effects of KCE on lipid accumulation in vitro. The chemical components characterizations and potential active chemical constituents of the bioactive KCE were analyzed using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) technology. Results: Among the chosen non-toxic concentrations of KCE (5, 10, 20 μg/mL), KCE can reduce the number and volume of lipid droplets in the oleic acid induced HepG2 cells in a dose-dependent manner, and the results of TGs quantification were almost consistent with the results of the oil red O staining experiment. These data indicate the KCE has ameliorative effect on lipid accumulation in vitro. In addition, a total of 26 compounds from the KCE were tentatively identified, dibenzocyclooctadiene lignans (DCLs) including Kadsulignan L and Gomisin J could be the main supposed components. Conclusion: These findings support further investigation into Kadsura coccinea containing DCLs as a new alternative medicinal arsenal to battle against NAFLD.

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“…For many decades, scientists explored the potential efficacy of plant and herb extracts/metabolites in enhancing poultry health, production and welfare as an alternative to antibiotics (Bhardwaj et al, 2021;Jambwa et al, 2023;Mnisi et al, 2023). PFS (phytogenic feed supplements) are natural molecules that are procured from herbs and widely employed for several purposes in human and animal trials for preventing some metabolic syndromes (do Moinho et al, 2022;Wang et al, 2022) or improving their health status and wellbeing (Pandey et al, 2019). Commercially, the PFS can exist in various shapes viz herbs, essential oils, active compounds, and spices (Steiner and Syed, 2015).…”

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confidence: 99%

The relationship between dietary curcumin supplementation and metabolic syndrome – A Review

El‐Hack

Alazragi

Khafaga

et al. 2024

Annals of Animal Science

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Metabolic syndrome is one of the utmost frequent diseases with the augmentation of the fast oscillations in societies’ lifestyles. On the other side, various medicinal plants have recently been extensively used for plentiful therapeutics. Among these, curcumin and turmeric are the main components derivative from the rhizome of plants, with significant effects on preventing metabolic syndromes. Due to their antioxidant and anti-inflammatory activities, the biological activities of turmeric and its bioactive element, curcumin, have antidiabetic properties via augmenting insulin release and anti-hyperlipidemia effects via enhancing fatty acids uptake, anti-obesity properties via declining lipogenesis, and antihypertensive properties via augmenting nitric oxide synthesis. Moreover, the dietary presence of turmeric and its bioactive element, curcumin, significantly affected poultry productivity, health and welfare. According to human and animal trials, turmeric or curcumin has important values as dietary supplementation and complementary therapy in some metabolic syndromes. This scenario highpoint on the potential effects of curcumin (turmeric) on poultry health and its role in complementary therapy in metabolic syndrome. Additional high-quality clinical trial investigations are required to establish the clinical efficiency of the curcumin complement confidently.

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A comprehensive review on phytochemicals for fatty liver: are they potential adjuvants?

Cited by 6 publications

References 166 publications

Biogenic Phytochemicals Modulating Obesity: From Molecular Mechanism to Preventive and Therapeutic Approaches

Biogenic Phytochemicals Modulating Obesity: From Molecular Mechanism to Preventive and Therapeutic Approaches

UPLC-Q-TOF-MS Analysis of Chemical Constituents of the Kadsura coccinea Extract with Effect of Attenuating Lipid Accumulation in Vitro

The relationship between dietary curcumin supplementation and metabolic syndrome – A Review

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