The Efficacy of Fucoidan on Gastric Ulcer

Abstract

Hyperacidity causes gastric injury, and in severe situations, ulcer could develop. The growth factors known as the basic fibroblast growth factor (bFGF) and the epidermal growth factor (EGF) have been recognized to promote ulcer healing. Fucoidan is extracted from a brown seaweed of Okinawa called Mozuku or Cladosiphon okamuranus. Fucoidan is effective for the healing of gastric ulcers by inducing epithelial cells to produce growth factors. The aim of this study is to explore the efficacy of fucoidan in patient who suffered by gastric ulcer. A randomized control trial double blind was conducted to 33 eligible samples. By using four-blocks random samples were divided into fucoidan and placebo groups. 100 mg of fucoidan was given to the fucoidan group and 100 mg of glucose was given to the placebo group. Due to ethical reasons, for both groups were given a proton pump inhibitor. There was no difference in the age category between the fucoidan group (mean: 46.23 ± 14.8 years) and the placebo group (mean: 46.18 ± 18.4 years) (p: 0.28). There was also no difference in sex between the fucoidan group (female: 10/33; male 7/33) and the placebo group (female: 7/33; male: 9/33); p: 0.38. According to the SAKITA and MIWA criterias 32 patients fulfilled A1 which indicate active severe ulcer, and 1 patient fulfilled A2 which indicate active moderate ulcer. Most of the ulcers were gastric ulcer. There was a significant improvement of the grade of ulcer in fucoidan group (94%) (16/17) compared to placebo group (37.5%) (6/16,p: 0.005). There was a significant reduction of abdominal pain after 5 days in the fucoidan group, compared to the placebo group (p: 0.04). Vomiting tends to decrease in day 6 of the fucoidan group however its proportion is similar with that of the placebo group (p: 0.9). Fucoidan is effective for ulcer healing and reducing ulcer symptoms.

Fucoidan Extracts Ameliorate Acute Colitis

“…Similarly, in a rat model of acute colitis, an orally delivered polysaccharide food supplement containing fucoidan reduced monocyte numbers and improved clinical markers of colitis [ 22 ]. Fucoidan is also known to protect against aspirin-induced gastric ulcers in a rat model [ 23 ] and is known from pre-clinical and clinical investigations to inhibit gastric pathogens [ 24 – 26 ].…”

Effect of fucoidan on gut microbiota and its clinical efficacy in Helicobacter pylori eradication: A randomized controlled trial

“…Wang et al 15 revealed that fucoidan protected against alcohol‐induced gastric mucosal damage. Juffrie et al 16 further verified the effect of fucoidan on ulcer healing and the improvement of ulcer symptoms. Other studies have also revealed that fucoidan can increase intestinal microbial diversity and modulate the microbiota composition 17 …”

Gastroprotective polysaccharide from natural sources: Review on structure, mechanism, and structure–activity relationship

“…Noteworthily, efficacies of sulfated polysaccharides in treating gastric diseases have been confirmed in clinical research. Dietary supplement of Cladosiphon okamuranus fucoidan for 3 weeks could improve the ulcer healing of patients with severe GU (Juffrie et al., 2011). GU patients treated with a sulfated polysaccharide exhibited dominant decreases in ulcer size per day (Zimmon et al., 1969).…”