The Effects of Topical Sesame (Sesamum indicum) Oil on Pain Severity and Amount of Received Non-Steroid Anti-Inflammatory Drugs in Patients with Upper or Lower Extremities Trauma

Abstract

Background:Most patients with trauma experience different levels of pain. Due to side effects as well as economic burden of drugs used for pain relief after trauma commonly, it is important to use low-cost methods independently or combined with drugs to alleviate pain.Objectives:Therefore, this study aimed to investigate the effects of topical sesame oil on pain severity and frequency of received NSAIDs of patients with trauma.Patients and Methods:This randomized clinical trial study was conducted on 150 patients with upper or lower extremities trauma in Dezful Ganjavian Hospital, Ahvaz, Iran, in 2014. Data was collected by a researcher-made questionnaire and Visual Analogue Scale (VAS). Patients were divided into two groups of control (n = 75) and intervention (n = 75) randomly. In the intervention group, patients applied topical sesame oil beside the routine cares, while in the control group patients just received routine cares. Severity of pain and frequency of received NSAIDs was assessed in the first, third, seventh and tenth days after the intervention in the both groups. Data was analyzed by SPSS19 software using descriptive and analytic (Chi-square and independent sample t-test) statistical methods.Results:Based on student sample t-test, there was a significant difference between intervention and control groups regarding the pain severity in the first (P = 0.06), third (P = 0.001), seventh (P = 0.001) and tenth (P = 0.001) days after the intervention. Besides, the frequency of received NSAIDs in the intervention group and the control group showed significant difference in four days after the intervention (for four days P = 0.001).Conclusions:Topical application of sesame oil could reduce pain severity and frequency of received NSAIDs in patients with upper or lower extremities trauma. Therefore, it is recommended to use this oil in complementary medicine for pain relief due to low cost, easy usage and lack of adverse effects.

Effectiveness of topical interventions to prevent or treat intravenous therapy‐related phlebitis: A systematic review

“…All of the studies concerning treatment included in this systematic review showed regression of symptoms of intravenous therapy‐related phlebitis (Becherucci et al, 2000; Ravindra & Krupta, 2015; Reis et al, 2011; Bigdeli Shamloo et al, 2015; Trillo & Esteban, 2006; Villardell et al, 1999). Three studies presented better symptom regression of intravenous therapy‐related phlebitis with treatment (Becherucci et al, 2000; Trillo & Esteban, 2006; Villardell et al, 1999).…”

“…The mechanisms of NSAID gel are already known; it inhibits prostaglandin G/H synthase, or cyclooxygenase, the enzyme that catalyses the transformation of arachidonic acid to prostaglandins and thromboxanes responsible for the inflammatory response (Teslim, 2014). In contrast, in addition to the anti‐inflammatory properties, sesame oil has anti‐mutagenic, anti‐oxidant, anti‐cardio and anti‐pyretic protective effects as well as anti‐nociceptive properties and is widely used in Iranian and Taiwanese traditional medicine (Bigdeli Shamloo et al, 2015).…”

Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils

“…In a rat model of monosodium urate monohydrate (MSU) crystal-induced acute inflammatory response in a pseudosynovial cavity, orally administered sesame oil reduced inflammation [ 92 ]. In a clinical study by Shamloo et al, topical application of sesame oil was shown to lower the severity of pain and reduce the frequency of nonsteroidal anti-inflammatory drug use in patients with limb trauma [ 93 ]. Topical sesame oil also protects the skin from UV radiation [ 65 ].…”

An Integrative Approach to Neuroinflammation in Psychiatric disorders and Neuropathic Pain

“… 95 In another randomized clinical study of 150 patients with limb trauma, topical application of sesame oil was shown to lower the severity of perceived pain and reduce the frequency of nonsteroidal anti-inflammatory drug use in these patients. 96 Clinical studies are needed to evaluate the effect of topical application of sesame oil on circulating cytokines, but sesame oil offers the potential to be useful as an adjunct therapy for treating neuroinflammation.…”