The effects of topical liposomal resveratrol on incisional and excisional wound healing process

Abstract

Background and Design: The objective of this study was to investigate the wound healing activity of different concentrations of liposomal trans-resveratrol formulations on incisional and excisional wounds in rats. Materials and Methods: The wound healing effect was tested by an excisional and incisional wound model. Wound closure was measured for 12 days. On the 12 th day of the study, maximal load, maximum stress, stress, and % of elongation values were evaluated in the incisional wound. In addition, angiogenesis, granulation tissue thickness, epidermal and dermal regeneration values, and macroscopic photographic analyses were evaluated in the excisional wound. Results: When the wound tissue surface healing rates were evaluated, similar effects were observed at the end of the 10 th and 12 th days between the 5% Res group and the commercial product containing 1% Centella asiatica extract used as the reference molecule. Histological evaluation showed that 1% Res and 5% Res groups induced significant wound healing activity compared to the control group. Furthermore, 1% Res and 5% Res groups increased wound healing rates by promoting granulation tissue, epidermal, and dermal regeneration as well as angiogenesis. Conclusion: Liposomal formulations containing 1% and 5% resveratrol were found to have positive effects on the healing process, both on excisional and incisional wound tissues.

In-vitro comparison release study of novel liposome and conventional formulation containing Rosmarinus officinalis extract

“…Liposome carrier systems were designed by thin film preparation method (Gunal et al, 2019). Firstly, liposome dispersions (HSP and Cholesterol) were designed by dissolving the 40 μmol mL −1 of phosphatidylcholine and lipophilic components in 30 mL chloroform in a round flask.…”

Evaluation of the Effect of Pomegranate Seed Oil on Healing in a Rat Wound Model With Antioxidant, Vascular, and Histopathological Parameters

“…Wound healing is not a stationary process, so the stages mentioned above may overlap. 2,3 Many factors influence the wound healing progress and any disruption may lead to defective tissue reconstruction.…”

Supporting the Wound Healing Process—Curcumin, Resveratrol and Baicalin in In Vitro Wound Healing Studies

“…Research has shown that nanocomposite hydrogels used for wound treatment exhibited significant inhibition against Gram-positive and Gram-negative bacteria due to Ag + ions released from silver nitrate [ 8 , 9 , 10 ]. Another readily used wound healing material is, for example, honey extract, which improves wound removal and cell proliferation, leading to faster closure of wound edges [ 11 , 12 , 13 , 14 , 15 ]. It is also beneficial due to its high sugar content, which creates a higher osmotic gradient that pulls fluid through the subdermal tissue and provides an additional source of glucose for the growth of cellular components in the wounded area [ 11 ].…”

“…It has a strong antioxidant, anti-inflammatory, antifungal and antibacterial effect as well as cardio- and neuroprotective properties [ 14 ]. Numerous studies also show its effectiveness against skin, prostate, lung, colon and liver cancer cells [ 15 , 16 ]. Furthermore, resveratrol has the ability to induce cell proliferation and accelerate wound closure in in vivo models in studies conducted on rats [ 21 ].…”