Supporting the Wound Healing Process—Curcumin, Resveratrol and Baicalin in In Vitro Wound Healing Studies

Jagiełło, Kacper; Uchańska, Oliwia; Matyja, Konrad; Jackowski, Mateusz; Wiatrak, Benita; Kubasiewicz−Ross, Paweł; Karuga-Kuźniewska, Ewa

doi:10.3390/ph16010082

Cited by 5 publications

(3 citation statements)

References 47 publications

(87 reference statements)

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“…However, after 3 and 7 days from the beginning of the experiment, in addition to the fact that no toxicity was observed against the L929 cell line, the cell viability and proliferation increased significantly compared to the control sample. This increase can be attributed to Cur release from the platform and subsequently stimulated the cell viability …”

Section: Resultsmentioning

confidence: 98%

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Drug-Loaded Carbon Nanotube Incorporated in Nanofibers: A Multifunctional Nanocomposite for Smart Chronic Wound Healing

Shakiba

Jahangiri

Rahmani

et al. 2023

ACS Appl. Polym. Mater.

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A proper dressing for chronic wounds should be able to preserve moisture while absorbing the exudates and exhibit good antibacterial properties and reliable mechanical properties. Furthermore, drug delivery through a wound dressing is an added value that brings more therapeutic and regenerative functionalities. In this study, a carboxylated multiwalled carbon nanotube–curcumin hybrid composite was embedded in a polyamide 6/poly(vinyl alcohol) nanofibrous composite (PA6/PVA/CMWCNT-Cur) for controlled drug release and potential wound healing application. PA6/PVA/CMWCNT-Cur nanofibrous composites were synthesized in two steps. First, Cur was loaded throughout the CMWCNT, and then a cross-linked PA6/PVA/CMWCNT-Cur blend solution was electrospun at CMWCNT-Cur concentrations of 0.5, 0.75, and 1 wt %. The results showed that incorporating PVA and CMWCNT-Cur into the PA6 nanofiber improved its wettability, physical properties, and biodegradability. In addition, the optical density technique demonstrated that the produced nanofibers had high antibacterial activity, which effectively inhibited the development of Staphylococcus aureus and Escherichia coli bacteria. Due to its uniform nanofibrous structure, superior mechanical capabilities, and excellent antibacterial features, the PA6/PVA/CMWCNT-Cur hybrid nanofibrous composite containing 0.75 wt % CMWCNT-Cur was chosen as the most suitable sample. Studies on the release of Cur from the nanofibers at different pH values demonstrated a faster rate in mild acidic media. The cell viability against the L929 cell line showed that the PA6/PVA/CMWCNT-Cur hybrid nanofibrous composite significantly increased the cell viability and proliferation. This work provides a simple and quick strategy for producing a multifunctional nanofibrous mat for wound healing applications.

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Section: Resultsmentioning

confidence: 98%

“…This increase can be attributed to Cur release from the platform and subsequently stimulated the cell viability. 69…”

Section: 7mentioning

confidence: 99%

Drug-Loaded Carbon Nanotube Incorporated in Nanofibers: A Multifunctional Nanocomposite for Smart Chronic Wound Healing

Shakiba

Jahangiri

Rahmani

et al. 2023

ACS Appl. Polym. Mater.

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“…RSV supplementation has beneficial effects on wound healing because it interferes with cellular and molecular pathways responsible for pathophysiological processes such as oxidative stress, inflammation, infection, autophagy, collagen proliferation, and angiogenesis [213,214].…”

Section: Wound Healing Propertiesmentioning

confidence: 99%

Resveratrol: A Review on the Biological Activity and Applications

Bejenaru,

Biţă,

Belu

et al. 2024

Applied Sciences

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Resveratrol (RSV), a naturally occurring phytoalexin, is the most important stilbenoid synthesized by plants as a defense mechanism in response to microbial aggression, toxins, or ultraviolet radiation. RSV came to the attention of researchers both as a potential chemopreventive agent and a possible explanation for the low incidence of cardiovascular disease (CVD) in French people with a high-fat diet. RSV is mainly administered as a food supplement, and its properties are evaluated in vitro or in vivo on various experimental models. RSV modulates signaling pathways that limit the spread of tumor cells, protects nerve cells from damage, is useful in the prevention of diabetes, and generally acts as an anti-aging natural compound. It was highlighted that RSV could ameliorate the consequences of an unhealthy lifestyle caused by an exaggerated caloric intake. This paper reviews the evidence supporting the beneficial effect of RSV for various pathological conditions, e.g., neoplastic diseases, neurodegeneration, metabolic syndrome, diabetes, obesity, CVDs, immune diseases, bacterial, viral, and fungal infections. The study also focused on the chromatographic analysis of trans-RSV (tRSV) in Romanian wine samples, providing a comprehensive overview of tRSV content across different types of wine.

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Curcumin Nanoemulgel: Characterization, Optimization, and Evaluation of Photoprotective Efficacy, Anti-Inflammatory Properties, and Antibacterial Activity

Bagheri,

Ranjbar,

Karami-Mohajeri

et al. 2024

J Clust Sci

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Supporting the Wound Healing Process—Curcumin, Resveratrol and Baicalin in In Vitro Wound Healing Studies

Cited by 5 publications

References 47 publications

Drug-Loaded Carbon Nanotube Incorporated in Nanofibers: A Multifunctional Nanocomposite for Smart Chronic Wound Healing

Drug-Loaded Carbon Nanotube Incorporated in Nanofibers: A Multifunctional Nanocomposite for Smart Chronic Wound Healing

Resveratrol: A Review on the Biological Activity and Applications

Curcumin Nanoemulgel: Characterization, Optimization, and Evaluation of Photoprotective Efficacy, Anti-Inflammatory Properties, and Antibacterial Activity

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