The effects of periodontal treatment on diabetic patients: The <scp>DIAPERIO</scp> randomized controlled trial

Vergnes, Jean-Noël; Canceill, Thibault; Vinel, Alexia; Laurencin‐Dalicieux, Sara; Maupas-Schwalm, Françoise; Blasco-Baqué, Vincent; Hanaire, H.; Arrivé, Élise; Rigalleau, Vincent; Nabet, Cathy; Sixou, Michel; Gourdy, Pierre; Monsarrat, Paul

doi:10.1111/jcpe.13003

Cited by 34 publications

(23 citation statements)

References 49 publications

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“…In the present study, the antibiotic was prescribed. This coincided with Vergnes et al () that recommended the use of antibiotic therapy for uncontrolled diabetes to prevent local infection after invasive dental therapies (Vergnes et al, ). Furthermore, the data from the present study demonstrated that the use of a combination of amoxicillin and metronidazole as adjunctive to SRP yielded considerable clinical and metabolic advantages at 3‐month follow‐up period.…”

Section: Discussionsupporting

confidence: 61%

The effects of non‐surgical periodontal therapy on glycemic control in diabetic patients: A randomized controlled trial

El‐Makaky

Shalaby

2020

Oral Diseases

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Aim The present study aimed to monitor the clinical outcomes and the metabolic response of periodontal therapy (non‐surgical) in patients with periodontitis (chronic) and uncontrolled diabetes (type 2). Methods Eighty‐eight subjects with periodontitis (chronic) and uncontrolled diabetes (type 2) were enrolled in this controlled trial and allocated randomly to the test group (44 patients were received immediate periodontal therapy) or the control group (44 patients were received delayed periodontal therapy). The metabolic and clinical evaluations were conducted at baseline and 3 months. This included clinical attachment level, glycated hemoglobin (HbA1c), bleeding on probing, visible plaque, and pocket depth. The periodontal therapy in this study consists of one‐stage scaling and root planning, a combination of systemic antibiotics (amoxicillin 500 mg and metronidazole 400 mg), and oral hygiene instructions. Results Regarding clinical and metabolic parameters at baseline, no statistically significant differences were displayed between the two groups. However, at 3‐month follow‐up period the patients within the test group demonstrated significantly better clinical and metabolic outcomes than patients in the control group. Conclusion The non‐surgical periodontal treatment using a combination of metronidazole and amoxicillin significantly improved the metabolic outcome in addition to periodontal health in diabetic subjects with chronic periodontitis.

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Section: Discussionsupporting

confidence: 61%

The effects of non‐surgical periodontal therapy on glycemic control in diabetic patients: A randomized controlled trial

El‐Makaky

Shalaby

2020

Oral Diseases

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“…However, the effect of periodontal treatment alone on uncontrolled type 2 diabetes mellitus in Thai older subjects was not signi cant although HbA1C values for the treatment group dropped by -0.2% three months after completion of the treatment 29 . Similar to full-mouth non-surgical scaling and root planing, it could improve periodontal health, but it had no signi cant effects on glycaemic control based on HbA1c values of -0.04% 30 .…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of the Oral Care Program in Type 2 Diabetic Elderly Patients with Periodontitis: A Clustered Randomised Controlled Study With 6-month Follow-Up

Phetnin¹,

Tippanart²,

Chuchai³

2020

Preprint

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Background: Diabetes mellitus and periodontal disease have a bidirectional relationship. This study aimed to assess the effectiveness of the oral care program in reducing glycaemic status and improving oral health behaviours and oral hygiene among type 2 diabetes mellitus (T2DM) older patients with periodontitis.Methods: A clustered randomised controlled study was conducted in Nakhon Ratchasima province between July 2019 and January 2020. The two health centres were randomly assigned to control and intervention groups, which thirty-five T2DM older patients with chronic periodontitis were recruited in each group. The intervention group received the program consisted of oral health education based on Health Belief Model (HBM), individual oral hygiene instruction and scaling and root planning at one month and followed by individual oral hygiene instruction at three months. The patients in the control group received the routine program provided by the health centre. Outcomes were measured using the interviewed questionnaire, simplified oral hygiene index, and the glycaemic status (HbA1c) at baseline, 3 months and 6 months, respectively. Data were analysed using a descriptive statistic, Chi-square test, t-test, repeated measure ANOVA at p-value = 0.05. Results: After the 3 and 6 months, the results showed that the intervention group significantly improved in the HBM scores, oral health behaviours scores, and decreased in OHI-S scores and HbA1c level (p < 0.05), while there was no significant difference in the control group.Conclusion: The findings suggested that the proposed program was effective among diabetic older people with periodontitis to improve oral health perception, behaviours, oral hygiene, and decreased glycaemic status at 3- and 6-month evaluation.Trial registration: Thai Clinical Trials Registry (TCTR), TCTR202004230005. Registered 22 April 2020 - Retrospectively registered.

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“…• Presence of at least six permanent teeth per mouth, excluding the third molars (Vergnes et al, 2018).…”

Section: Inclusion Criteriamentioning

confidence: 99%

“…Thorough medical history, data on age, and socio-demographic characteristics were gathered for all participants in study groups at the baseline to reveal any significant variations between study groups concerning age, family size, residence, and occupation which make external variables that could affect the study findings (Quintero et al, 2018;Vergnes et al, 2018). A full-mouth periodontal screening was carried out by one specialist (MY) using a manual probe (Hu-Friedy).…”

Section: Clinical and Periodontal Evaluationmentioning

confidence: 99%

Salivary tumor necrosis factor‐alpha to detect the severity of erectile dysfunction: A randomized clinical trial

2020

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Aim This study aimed to provide evidence on the impact of chronic periodontitis (CP) on the severity of erectile dysfunction (ED) through the assessment of the salivary level of tumor necrosis factor‐alpha (TNF‐α). Methods 140 patients with chronic periodontitis and erectile dysfunction were enrolled in this study and then randomly allocated to the control group (70 participants received delayed periodontal treatment) or test group (70 participants were subjected to immediate periodontal therapy). The assessment of the clinical and serological outcomes was done at baseline and 3 months postoperatively. This included pocket depth (PD), visible plaque, clinical attachment level (CAL), bleeding on probing (BOP), level of tumor necrosis factor‐alpha (TNF‐α), and the severity of erectile dysfunction. Periodontal therapy consists of oral hygiene instructions and single‐visit scaling and root planing. Results There were no significant differences regarding the serological and clinical outcomes at baseline between the two groups (p > .05). At 3‐month follow‐up, the PD, BOP, CAL, and visible dental plaque means in the control group were significantly higher than those in the test group (PD: 4.94 ± 0.647 mm vs. 4.25 ± 0.619 mm; BOP: 49.03 ± 29.98 vs. 6.20 ± 7.14; CAL: 4.96 ± 0.631 mm vs. 4.31 ± 0.591 mm; visible dental plaque: 48.49 ± 30.07 vs. 5.83 ± 6.51) (p = .00). Compared with baseline findings, both groups showed significant reductions in TNF‐α in serum, salivary TNF‐α, and severity of erectile dysfunction (p < .001). Conclusion The non‐surgical periodontal therapy could significantly improve the severity of erectile dysfunction in addition to periodontal and serological parameters. Salivary TNF‐α could be used as a new diagnostic tool to detect the severity of erectile dysfunction.

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The effects of periodontal treatment on diabetic patients: The DIAPERIO randomized controlled trial

Cited by 34 publications

References 49 publications

The effects of non‐surgical periodontal therapy on glycemic control in diabetic patients: A randomized controlled trial

The effects of non‐surgical periodontal therapy on glycemic control in diabetic patients: A randomized controlled trial

Effectiveness of the Oral Care Program in Type 2 Diabetic Elderly Patients with Periodontitis: A Clustered Randomised Controlled Study With 6-month Follow-Up

Salivary tumor necrosis factor‐alpha to detect the severity of erectile dysfunction: A randomized clinical trial

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The effects of periodontal treatment on diabetic patients: The DIAPERIO randomized controlled trial

Cited by 34 publications

References 49 publications

The effects of non‐surgical periodontal therapy on glycemic control in diabetic patients: A randomized controlled trial

The effects of non‐surgical periodontal therapy on glycemic control in diabetic patients: A randomized controlled trial

Effectiveness of the Oral Care Program&nbsp;in Type 2 Diabetic Elderly Patients with Periodontitis:&nbsp;A Clustered Randomised&nbsp;Controlled Study With 6-month Follow-Up

Salivary tumor necrosis factor‐alpha to detect the severity of erectile dysfunction: A randomized clinical trial

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Effectiveness of the Oral Care Program in Type 2 Diabetic Elderly Patients with Periodontitis: A Clustered Randomised Controlled Study With 6-month Follow-Up