The oral cavity is host to a complex and diverse microbiota community which plays an important role in health and disease. Major oral infections, i.e., caries and periodontal diseases, are both responsible for and induced by oral microbiota dysbiosis. This dysbiosis is known to have an impact on other chronic systemic diseases, whether triggering or aggravating them, making the oral microbiota a novel target in diagnosing, following, and treating systemic diseases. In this review, we summarize the major roles that oral microbiota can play in systemic disease development and aggravation and also how novel tools can help investigate this complex ecosystem. Finally, we describe new therapeutic approaches based on oral bacterial recolonization or host modulation therapies. Collaboration in diagnosis and treatment between oral specialists and general health specialists is of key importance in bridging oral and systemic health and disease and improving patients' wellbeing.
Although periodontal treatment showed no clinical effect on glycaemic control in this trial, important data were provided to support periodontal care among diabetic patients. Periodontal treatment is safe and improves oral health-related QoL in patients living with diabetes. ISRCTN15334496.
The aim of this study was to analyze the link between oral microbiota and obesity in humans. We conducted a pilot study including 19 subjects with periodontitis divided into two groups: normo-weighted subjects (NWS) with a body mass index (BMI) between 20 and 25 (n = 9) and obese subjects (OS) with a BMI > 30 (n = 10). Obesity was associated with a poor oral health status characterized by an increased number of missing teeth and a higher score of periodontal-support loss associated with dysbiotic oral microbiota (39.45 ± 3.74 vs. 26.41 ± 11.21, p = 0.03 for the Chao 1 index). Oral microbiota taxonomic analysis showed that the abundance of the Capnocytophaga genus was higher (2.47% ± 3.02 vs. 0.27% ± 0.29, p = 0.04) in OS compared to NWS. Obese females (OF) were characterized by an increase in the Streptococcus genus (34.12% ± 14.29 vs. 10.55% ± 10.42, p = 0.05) compared to obese males (OM), where the Neisseria genus was increased (5.75% ± 5.03 vs. 58.05% ± 30.64, p = 0.008). These first data suggest that sex/gender is determinant in the link between oral dysbiotic microbiota and obesity in patients with periodontitis. Our results could lead to recommendations concerning therapeutic strategies for obese patients with periodontitis following the sex/gender.
Non-stoichiometric nanocrystalline apatites present enhanced bioactivity compared to stoichiometric hydroxyapatite. The purpose of this work was to modify the calcium phosphates (CaP) generally used to prepare bioactive ceramics in the aim of obtaining a biomimetic apatite powder. Hydroxyapatite (HA) powder, amorphous tricalcium phosphate (amTCP) powder and a blend of these two were modified by means of an innovative, simple, ''green'' carbonation process, involving water and high-pressure CO 2 (80 bar). This process induced a modification of the CaP, which is sensitive to the environment in which it is located and, in particular, to the pH variations that occur during the treatment phase (decrease in the pH) and during the degassing phase (return to neutral pH). FTIR and Raman spectroscopy, XRD and SEM analyses showed that, depending on the type of initial CaP powder, high-pressure CO 2 treatment led to the formation of different types of calcium phosphate phases. This process allowed partial dissolution of the initial powder, mainly of TCP when present, and precipitation of a new CaP phase. HA and HA/amTCP powders were transformed into a mixture of OCP and immature carbonated apatite (PCCA) phases, including OCP maturation/transformation into PCCA. In the case of amTCP powder, a DCPD phase was also present due to the high TCP solubility and an earlier precipitation during the degassing step. This work shows the great potential of such an innovative low-temperature and high-pressure process to transform HA, HA/TCP and TCP powder into bioactive biphasic ceramics composed of OCP and PCCA similar to bone mineral.
Poly-(etheretherketone) (PEEK) began to be used in the field of odontology more than 10 years ago, especially in relation to the creation of removable partial dentures. Here we report the case of a 62 years old woman diagnosed with histamine intolerance (or histaminosis), who presented a very particular set of oral symptoms. She described a certain tingling, burning, and swelling of the mucous membranes. These symptoms seem to be linked with the wearing of a resin occlusal splint which was initially prescribed to compensate for the absence of a meniscus in the left temporomandibular joint of the patient. After a multidisciplinary concertation, it was decided to create a new splint with a resin-free material. For this reason, the production of a PEEK prosthesis was considered. Following the installation of the occlusal splint in the patient, and after clinical adjustments, she described the occlusion positioning as correct and a disappearance of the symptomatology. Mechanically, PEEK seems to have higher mechanical resistance than PMMA. Despite these characteristics, the use of PEEK still presents some limitations, especially concerning the overall aesthetic. Additionally, the prescription of the occlusal splint seems to be limited to patients who need special care. The case presented here thus confirms a new perspective concerning the use of PEEK as an occlusal splint.
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