The effects of hypervitaminosis A in sheep following intramuscular administrations of vitamin A

Raoofi, Afshin; Asadi, Farzad; Mardjanmehr, Seyed Hossein; Kazempoor, Reza

doi:10.1016/j.fct.2009.09.038

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…This result is not in agreement with the findings of previous studies on rats (JeyAkumAr et al, 2005) and lambs (RAooFi et al, 2010), where they found that feeding of high but non-toxic doses of vitamin A significantly reduces body weight.…”

Section: Organs and Body Weightscontrasting

confidence: 55%

Effects of vitamin A overdose on rat’s organs involved in immunity and vitamin A storage

Mahassni¹,

Alshaikh²

2014

Acta Alimentaria

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Vitamin A overdose is a common occurrence due to food fortification and ingestion of vitamin A supplements. Vitamin A is a nutrient that possesses known and potential effects on general health and the immune response. This research work is an in vivo investigation of the effects of administration of vitamin A above dietary requirements on some organs involved in immunity, vitamin A storage, and metabolism in healthy male rats. A total of 60 young adult male Wistar rats were equally divided into three groups. Rats in the two test groups were orally administered with vitamin A at different concentrations (8000 and 15 000 IU kg -1 body weight) for 21 days, while the control rats did not receive any supplementation. Weekly body weights and weights of the liver, kidney, spleen, and thymus were measured. Histological evaluations were carried out on the liver, kidney, thymus, and Peyer's patches. Findings show that vitamin A did not significantly affect body and organs' weights, except for a significant decrease of spleen weights for both experimental groups. Vitamin A was found to lead to some changes in the histology of the tested organs. This is the first study of its kind and sets a base for future studies.

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Section: Organs and Body Weightscontrasting

confidence: 55%

Effects of vitamin A overdose on rat’s organs involved in immunity and vitamin A storage

Mahassni¹,

Alshaikh²

2014

Acta Alimentaria

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“…Vitamin A is a fat-soluble vitamin essential for vision, growth, cellular differentiation and the integrity of the immune system. 1 Its established tolerable upper limit (UL) of safety is of ~ 2,800 to 3,000 µg/day for adult men and women. 2 The prevalence of exceeding this limit in populations with adequate dietary content of vitamin A has been shown to range between 10% and 31%.…”

Section: Introductionmentioning

confidence: 99%

“…6 Overt liver cirrhosis has also been documented following prolonged intake of high doses vitamin A supplements. 7,8 The hepatotoxicity profile includes hyperplasia of the hepatocytes and hepatic stellate cells (HSCs), 1,9 and an increase in the number and size of the vacuoles found in these cells. 10 The temporal sequence of these changes in response to hypervita-minosis A, however, is yet to be quantified.…”

Section: Introductionmentioning

confidence: 99%

Hypervitaminosis A Causes Reversible Changes in the Density of Hepatocytes and Hepatic Stellate Cells of Albino Rats (Rattus norvegicus)

Munguti¹,

Obimbo²,

Odula³

et al. 2020

JMS

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Background: hypervitaminosis A causes hyperplasia and vacuolation of hepatocytes and hepatic stellate cells (HSCs). The temporal sequence of these changes and the sequalae of their spontaneous reversion, however, remain largely unquantified. Methods: ethical approval was obtained from the Biosafety, Animal Use and Ethics Committee of the School of Veterinary Medicine at the University of Nairobi. A total of 45 adult albino rats were randomly divided into 3 groups. In groups A and B, 300,000 IU/Kg of vitamin A were administered to the rats every other day via subcutaneous injection for 4 and 8 weeks respectively. The rats in group C formed the control group. In total, 5 rats from group A were euthanized weekly at weeks 2, 4, 6 and 8, while those from group B were euthanized at weeks 6, 8, 10 and 12. Multistage systematic uniform random sampling was used to select harvested liver segments that were processed for histological staining. A one-way analysis of variance (ANOVA) was used to compare cell density in the 3 groups and over time. The Tukey test was used to detect the differences between the groups. Values of p < 0.05 were considered statistically significant at 95%confidence interval (95%CI). Results: in both the acutely-and chronically-exposed groups, there was a significant increaseinhepatocyte(p < 0.001) and HSC (p − 0.066) density over time. Stopping the exposure resulted in a significant decline in both cell lines (p < 0.05). Compensatory hyperplasia and hypertrophy of these cells emanated from the periportal areas. Conclusion: hepatocytes are more adversely affected by hypervitaminosis A compared to HSC, which reflects their active role in the metabolism of vitamin A.

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Effects of parenteral over-supplementation of vitamin A and iron on hematology, iron biochemistry, weight gain, and health of neonatal dairy calves

Moosavian

Mohri

Seifi

2010

Food and Chemical Toxicology

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The effects of hypervitaminosis A in sheep following intramuscular administrations of vitamin A

Cited by 5 publications

References 17 publications

Effects of vitamin A overdose on rat’s organs involved in immunity and vitamin A storage

Effects of vitamin A overdose on rat’s organs involved in immunity and vitamin A storage

Hypervitaminosis A Causes Reversible Changes in the Density of Hepatocytes and Hepatic Stellate Cells of Albino Rats (Rattus norvegicus)

Effects of parenteral over-supplementation of vitamin A and iron on hematology, iron biochemistry, weight gain, and health of neonatal dairy calves

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