Effects of parenteral over-supplementation of vitamin A and iron on hematology, iron biochemistry, weight gain, and health of neonatal dairy calves

Moosavian, Hamidreza; Mohri, Mehrdad; Seifi, Hesam A

doi:10.1016/j.fct.2010.02.030

Cited by 23 publications

(26 citation statements)

References 23 publications

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“…The life span of E in cattle lasts 160 days. Different authors studied values of haematological variables in calves and observed that the values are changing with age (Greatorex, 1954;Scheidegger, 1973;Hanschke & Schulz, 1982;Steinhardt & Thielscher, 2000a;Steinhardt & Thielscher, 2000b;Klinkon et al, 2000;Brun-Hansen et al, 2006;Moosavian et al, 2010;Mohri et al, 2010). Immediately after parturition the values of (PCV), haemoglobin (Hb) and number of E are higher and they decreased in first days of life what could be associated with colostrum intake, which increase the plasma volume due to osmotic effect (Scheidegger, 1973;Harvey, 1997).…”

Section: Haematological Variables In Calvesmentioning

confidence: 99%

Values of Blood Variables in Calves

Klinkon¹,

Ježek²

2012

A Bird's-Eye View of Veterinary Medicine

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Section: Haematological Variables In Calvesmentioning

confidence: 99%

Values of Blood Variables in Calves

Klinkon¹,

Ježek²

2012

A Bird's-Eye View of Veterinary Medicine

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“…Vitamin A is essential for normal growth, differentiation of epithelial tissues, reproduction, and adequate immune function. A lack of vitamin A can result in decreased disease resistance and increased mortality, particularly in growing animals (Frye et al 1991;Puvogel et al 2005;Moosavian et al 2010). Increased susceptibility to bacterial infections, particularly mastitis and pneumonia, reproductive failure, and postpartum diseases such as retained placenta and metritis have been associated with hypovitaminosis A (Chew et al 1982;Frye et al 1991;Michal et al 1994;He et al 2012).…”

mentioning

confidence: 99%

Factors associated with serum vitamin A and E concentrations in beef calves from Alberta and Saskatchewan and the relationship between vitamin concentrations and calf health outcomes

Waldner

Uehlinger

2016

Can. J. Anim. Sci.

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The study objectives were to identify factors associated with serum vitamin A and vitamin E concentrations in beef calves less than 1 mo old and to examine associations between vitamin concentrations and health outcomes. Serum vitamin A concentrations were highest in calves more than 4 d old, with serum immunoglobulin G concentrations > 19 g L −1 , from cows without perinatal health problems, and born where precipitation in the previous growing season was ≥200 mm. Serum vitamin E was highest in calves more than 4 d old, born earlier in the calving season, not born to heifers, and that received selenium and vitamin E injections at or shortly after birth. After accounting for other risk factors, calves with serum vitamin A less than 0.14 μg mL −1 were 2.8 times more likely to die (P = 0.02), and calves with serum vitamin E less than adequate for their age (2-7 d old, <0.8 μg mL −1 ; >7 d old, <0.5 μg mL −1) were 3.2 times more likely to be treated for enteritis than calves with higher concentrations (P = 0.0001). Drought conditions, dam peripartum health problems, and inadequate colostrum intake contribute to low vitamin A and vitamin E concentrations and adverse health outcomes in beef calves.

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“…Indeed, in situations of iron deficiency in rats, iron is a critical determinant of IGF-I regulation (Tran et al 2012), and previous research has also shown that iron deficiency reduces GH-mediated IGF-I secretion (Ceppi and Blum 1994). Nevertheless, conversely to what was observed in the iron deficiency state, parenteral administration of iron in calves during the early postnatal period resulted in a rise of serum IGF-I concentrations (Moosavian et al 2010). The significant reduction of serum IGF-I observed in iron-deficient calves is therefore more likely a consequence of altered iron status, indicating an important relationship between the iron status and IGF-I activity in 10-day-old calves.…”

Section: Indicatorsmentioning

confidence: 67%

“…The most severe consequence of this disorder is iron deficiency anaemia, which is considered to be common in the veal industry but not in calves fed roughage with concentrates and mineral/vitamin supplements (Lindt and Blum 1994). However, a significant incidence of anaemia in neonatal calves has been reported by Bostedt et al (1990) and by Moosavian et al (2010).…”

mentioning

confidence: 96%

Relationship between serum iron and insulin-like growth factor-I concentrations in 10-day-old calves

et al. 2014

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Newborn calves are often deficient in iron and progressive reduction in blood iron concentration occurs over the first weeks of life. Some reports indicate the importance of interactions among iron and components of the insulin-like growth factor system. The aim of the study was to determine if there is a relationship between serum iron and insulin-like growth factor-I concentrations in neonatal calves. Blood samples were collected from 16 female Holstein-Friesian calves on day 10 of age. Erythrogram determination and measurements of serum iron, total protein, albumin, total iron binding capacity and serum insulin-like growth factor-I concentrations were performed. Haematological values were measured using an automatic analyzer, biochemical properties were determined spectrophotometrically, insulin-like growth factor-I concentration was measured by radioimmunoassay. Calves were divided into 2 groups according to iron concentrations; the first group of iron-deficient calves (n = 8, Fe < 10 μmol/l) and the second group of calves with optimal iron concentration (n = 8, Fe > 18 μmol/l). Blood indicators in all calves from the first group followed a pattern typically observed in anaemic calves. Insulin-like growth factor-I concentrations were significantly (P < 0.01) lower in the first group compared to the second group. However, insulin-like growth factor-I very strongly correlated with iron in calves from the second group compared to iron-deficient calves (r = 0.624; P < 0.01 and r = 0.478; P > 0.05, respectively). Based on our results, iron seems to have an important relationship to secretion of insulin-like growth factor-I in 10-day-old calves. This is the first report about such relationship in this age group of animals. Calf, haematology, IGF-I, iron deficiency

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Effects of parenteral over-supplementation of vitamin A and iron on hematology, iron biochemistry, weight gain, and health of neonatal dairy calves

Cited by 23 publications

References 23 publications

Values of Blood Variables in Calves

Values of Blood Variables in Calves

Factors associated with serum vitamin A and E concentrations in beef calves from Alberta and Saskatchewan and the relationship between vitamin concentrations and calf health outcomes

Relationship between serum iron and insulin-like growth factor-I concentrations in 10-day-old calves

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