Abstract:Background: hypervitaminosis A causes hyperplasia and vacuolation of hepatocytes and hepatic stellate cells (HSCs). The temporal sequence of these changes and the sequalae of their spontaneous reversion, however, remain largely unquantified. Methods: ethical approval was obtained from the Biosafety, Animal Use and Ethics Committee of the School of Veterinary Medicine at the University of Nairobi. A total of 45 adult albino rats were randomly divided into 3 groups. In groups A and B, 300,000 IU/Kg of vitamin A … Show more
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