The effects of helicobacter pylori eradication on modification of metabolic syndrome parameters in patients with functional dyspepsia

Mokhtare, Marjan; Mirfakhraee, Hosna; Arshad, Mahmoud; Fard, Seyed Hossein Samadani; Bahardoust, Mansour; Movahed, Alireza; Masoodi, Mohsen

doi:10.1016/j.dsx.2017.07.035

Cited by 27 publications

(22 citation statements)

References 17 publications

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“…In a Chinese study [6], patients infected with Helicobacter pylori were characterized by a higher level of fasting blood glucose and higher BMI. Awareness of this correlation is particularly important, considering a study conducted by Mokhtare et al who observed that effective eradication of Helicobacter pylori infection resulted in a reduction in fasting blood glucose and HbA 1c , improvement in lipid profile and reduction in waist circumference [7]. It means that thanks to the treatment of Helicobacter pylori infection, there is a potential chance of improving the prognosis in a large group of patients participating in our study.…”

Section: Discussionmentioning

confidence: 80%

Evaluation of the prevalence of glucose metabolism disorders in patients with dyspepsia

Moczulska

Knysak

Bryczkowska

et al. 2019

Clinical Diabetology

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Introduction. As estimated by IDF, by 2045 there will be about 628 million of people living with diabetes, of which 87-91% will have type 2 diabetes. Therefore, early diagnosis of diabetes is very important, and currently only 4-50% of cases are diagnosed early enough. The aim of the study was to establish whether patients with dyspepsia may potentially be a group at high risk of developing diabetes in which screening for glucose metabolism disorders would be particularly important. Material and methods. The study included 59 women (65.5%) and 31 men (34.5%), with a mean age of 36 years, hospitalized in order to perform gastroscopy due to symptoms of dyspepsia. All patients were apparently healthy, without the history of cardiovascular diseases or diabetes, and were non-smokers. The patients were subjected to laboratory tests (random blood glucose, oral glucose tolerance test [OGTT], lipid profile, C-reactive protein level), gastroscopy and a rapid urease test for detection of active Helicobacter pylori infection. Body mass index (BMI) was also calculated. Subjects with abnormal results of the oral glucose tolerance test (OGTT) were assigned to the group with glucose metabolism disorders and the remaining subjectsto the group without glucose metabolism disorders. Statistical analysis of the obtained research results was carried out using the Statistica 7.0 PL software. Results. The subjects were divided into two subgroups based on the result of the oral glucose tolerance test, adopting the principles of diagnosing carbohydrate metabolism disorders according to the Diabetes Poland. The group with glucose metabolism disorders included 33 patients (36.5%): 5 subjects (5.5%) with impaired fasting glucose, 20 patients (22%) with impaired glucose tolerance and 8 patients (9%) with diabetes. The remaining 57 (63.5%) patients had normal results of OGTT and were assigned to the group without glucose metabolism disorders. The mean BMI in the whole examined population was 26.7 kg/m 2. Patients with glucose metabolism disorders (GMD) had a significantly higher BMI (31.1 kg/m 2). The levels of total cholesterol, LDL cholesterol and TG were higher in patients with GDM; however, the difference was not statistically significant. Random blood glucose values were significantly higher in the group with GDM, but no patient had random blood glucose ≥ 200 mg/dL. The HbA 1c value was significantly higher in the GMD group. Also, the C-reactive protein (CRP) level was significantly higher in the group of patients with GMD than in the group of healthy subjects. All patients underwent gastroscopy and abnormal results were found in 41 patients (45.5% of total study population)-in 67% in the group with GMD and 33% in the group without GDM. The most frequent pathology was Helicobacter pylori infection (25.5%). This infection was more prevalent in the group with GDM (45%) than in the group without GDM (14%). In addition, gastritis, gastric cancer, gastro-esophageal reflux, hiatal hernia, and gastric polyps were found, without significant diffe...

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Section: Discussionmentioning

confidence: 80%

Evaluation of the prevalence of glucose metabolism disorders in patients with dyspepsia

Moczulska

Knysak

Bryczkowska

et al. 2019

Clinical Diabetology

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“…No significant changes were observed for systolic and diastolic blood pressure and triglyceride levels. These results suggest that H. spylori eradication may improve parameters of MS …”

Section: Metabolic Syndromementioning

confidence: 73%

Helicobacter pylori and extragastric diseases

2018

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Many studies have been performed in the last year concerning the potential role of Helicobacter pylori in different extragastric diseases, reinforcing the idea that specific microorganisms may cause diseases even far from the primary site of infection. While the role of H. pylori on idiopathic thrombocytopenic purpura, sideropenic anemia, and vitamin B12 deficiency has been well established, there is a growing interest in other conditions, such as cardiovascular, neurologic, dermatologic, obstetric, immunologic, and metabolic diseases. Concerning neurologic diseases, there is a great interest in cognitive impairment and neurodegeneration. The aim of this review was to summarize the results of the most relevant studies published over the last year on this fascinating topic.

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“…Предполагается, что вклад H. pylori в развитие МС может быть связан с длительной персистенцией хронического воспаления слизистой оболочки желудка, продукцией активных форм кислорода и модуляцией выработки грелина и лептина [38,39]. В нескольких отдельных исследованиях показано положительное влияние эрадикации H. pylori на показатели биохимических и клинических маркеров хронического воспаления и МС [40,41]. Дальнейшие проспективные исследования должны осветить роль антихеликобактерной терапии в коррекции проявлений МС.…”

Section: метаболические нарушенияunclassified

Helicobacter pylori and extragastroduodenal diseases: the proven facts and assumptions

Маев¹,

Бакулин²,

Курилович³

et al. 2018

Dok. gastroenterol.

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В обзоре освещены современные данные об ассоциации инфекции Helicobacter pylori с экстрагастродуоденальными заболеваниями. Проанализирована как негативная, так и защитная роль Н. pylori при заболеваниях крови, центральной нервной системы, органов сердечно-сосудистой и дыхательной систем, метаболических нарушениях, болезнях кишечника и кожи. Рассмотрен потенциальный эффект антихеликобактерной терапии при данной патологии.

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The effects of helicobacter pylori eradication on modification of metabolic syndrome parameters in patients with functional dyspepsia

Cited by 27 publications

References 17 publications

Evaluation of the prevalence of glucose metabolism disorders in patients with dyspepsia

Evaluation of the prevalence of glucose metabolism disorders in patients with dyspepsia

Helicobacter pylori and extragastric diseases

Helicobacter pylori and extragastroduodenal diseases: the proven facts and assumptions

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