The effects of chronic low-dose capsaicin treatment on substance P levels

Erin, Nuray; Zık, Berrin; Sarigul, M.; Tütüncü, Şerife

doi:10.1016/j.regpep.2008.10.007

Cited by 8 publications

(3 citation statements)

References 26 publications

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“…Therefore, a multimodal therapy proposal would be the better indicated, contemplating the several inflammatory factors that involve the formation and maintenance of the keloid. In the presented case, multimodal therapy performed included dietary guidance, in order to avoid consumption of ‘skin proinflammatory’ foods—those containing omega‐6 fatty acids, 31,32 rich in trans fats (processed and frozen foods) and saturated fats (pork and dairy products), 31 chitosan (seafood), 33 isoflavones (soybeans), 34 capsaicin 35 and phytosterol (avocado) 34 . Although there is no robust evidence regarding the influence of diet on scarring, the lipid model for keloids has gained attention, as deficiency of essential fatty acids from inflammatory precursors and competitors of arachidonic acid may be a factor in the multifactorial aetiology of keloid formation 36 …”

Section: Discussionmentioning

confidence: 99%

Keloids in male genitalia—Systematic review and illustrative case report

Isoldi,

Garcia,

Vieites

et al. 2024

Wound Repair Regeneration

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Keloid is the maximum expression of pathological fibroproliferative skin wound healing, whose pathophysiology is not yet fully understood. Its occurrence in the perineum and genitalia is uncommon. A systematic review was carried out regarding the occurrence and treatment of keloids on the penis. An illustrative case was also reported. The review used the PRISMA checklist and was registered in PROSPERO. The entire literature period up to April 2023 was searched in the EMBASE/Elsevier, Cochrane, Scopus, Medline, BVS, SciELO, and Lilacs databases. The inclusion criteria embraced primary studies, clinical trials, prospective or retrospective cohorts, case series, case–control studies and case reports. Three hundred and sixty‐one studies were found and 12 of them were included, consisting of 9 case reports and 3 case series. The most common triggering factor for keloid formation was circumcision, in 11 of the cases, of which more than half occurred in prepubescent children. Several therapies, associated or isolated, were used to treat the cases. Only one of the reported patients had scar recurrence after surgical treatment. Studies with better scientific evidence are needed to understand the involvement of keloids in male genitalia. However, keloid formation in this topography is rare, making it difficult to carry out more elaborate studies.

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Section: Discussionmentioning

confidence: 99%

Keloids in male genitalia—Systematic review and illustrative case report

Isoldi,

Garcia,

Vieites

et al. 2024

Wound Repair Regeneration

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“…In addition, SP is found in neutrophils, eosinophils, macrophages, and dendritic cells. SP plays roles in muscle contraction, epithelial ion transport, vascular permeability, and the regulation of immune function[ 18 - 23 ]. The inflammatory activity of SP has often been shown in in vitro studies and in animal experiments.…”

Section: Discussionmentioning

confidence: 99%

Childhood chronic gastritis and duodenitis: Role of altered sensory neuromediators

İşlek

Yılmaz

Elpek

et al. 2016

WJG

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AIMTo investigate the roles of the neuropeptides vasoactive intestinal peptide (VIP), substance P (SP), and calcitonin gene-related peptide (CGRP) in chronic gastritis and duodenitis in children.METHODSBiopsy samples from the gastric and duodenal mucosa of 52 patients and 30 control subjects were obtained. Samples were taken for pathological examination, immunohistochemical staining, enzyme activity measurements and quantitative measurements of tissue peptide levels.RESULTSWe observed differential effects of the disease on peptide levels, which were somewhat different from previously reported changes in chronic gastritis in adults. Specifically, SP was increased and CGRP and VIP were decreased in patients with gastritis. The changes were more prominent at sites where gastritis was severe, but significant changes were also observed in neighboring areas where gastritis was less severe. Furthermore, the degree of changes was correlated with the pathological grade of the disease. The expression of CD10, the enzyme primarily involved in SP hydrolysis, was also decreased in patients with duodenitis.CONCLUSIONBased on these findings, we propose that decreased levels of VIP and CGRP and increased levels of SP contribute to pathological changes in gastric mucosa. Hence, new treatments targeting these molecules may have therapeutic and preventive effects.

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“…On prolonged activation of TRPV1 receptors having neurons by capsaicin depletes presynaptic substance P. Systemic exposure to low-dose capsaicin enhances sensory nerve functions and also increases substance P in nonneuronal tissues. [10] The capsaicin (vanilloid) receptor also plays an important role in transducing thermal and inflammatory pain. Mice lacking the VR 1 genes deficits in thermal-or inflammation-induced hyperalgesia, which confirms the involvement of this channel in pain sensation, especially the sensation of heat-evoked pain.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Capsaicin: A promising therapy - A critical reappraisal

Chhabra

Aseri

Goyal

et al. 2012

Int J Nutr Pharmacol Neurol Dis

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Capsaicin, major capsainoid, derived from dried fruit of chilli pepper, is synthesized in the interlocular septa of chilli peppers by addition of a branched-chain fatty acid to vanillylamine. An extensive, although largely forgotten, literature addresses the utility of the capsaicin therapy as either adjunctive or main treatment strategy for a number of diseases. Topical capsaicin has been shown to improve the outcome in neuropathic and musculoskeletal pain, post herpetic neuralgia, arthritic pain, burning mouth syndrome, pain due to fibromyalgia, psoriatic disorder, burning mouth syndrome, various allergic disorders, and as intranasally for cluster headache. Capsaicin is under development therapy for various diseases, it may develop as a new treatment therapy for a number of diseases in near future. However, studies with systemic ingestion are limited and have been shown gastrointestinal adverse effects, which may be major limitations to systemic capsaicin therapy.

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The effects of chronic low-dose capsaicin treatment on substance P levels

Cited by 8 publications

References 26 publications

Keloids in male genitalia—Systematic review and illustrative case report

Keloids in male genitalia—Systematic review and illustrative case report

Childhood chronic gastritis and duodenitis: Role of altered sensory neuromediators

Capsaicin: A promising therapy - A critical reappraisal

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