Capsaicin: A promising therapy - A critical reappraisal

Chhabra, Naveen; Aseri, M K Gharibn; Goyal, Vandana; Sankhla, Sanjay

doi:10.4103/2231-0738.93124

Cited by 12 publications

(3 citation statements)

References 46 publications

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“…Capsaicin is the main capsaicinoid in chili peppers. Capsaicin is currently used in topical ointments, as well as a high-dose dermal patch, to relieve the pain of peripheral neuropathy such as post-herpetic neuralgia caused by shingles (Chhabra, Aseri, Goyal, & Sankhla, 2012). Many pharmacological studies have used capsaicin as a tool to activate many physiological systems, with an emphasis on pain research, but also including functions such as the cardiovascular system, the respiratory system, and the urinary tract (O'Neill et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Effects of Thymoquinone or Capsaicin against Acrylamide-Induced Testicular Failure in Rats: Impact Oxidative Stress, NF-Κb/P65, and Occludin

Hasan¹,

haleem²,

Arafa³

2020

Preprint

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Endocrine disrupting effects have become a major issue in the field of environmental toxicology. Due to the testicular toxicity reported for acrylamide and confirmed in our study, and the double jeopardy with its well-documented carcinogenicity following leaching out from overcooked starchy foods, the current study was extended to address the possible protective effects of two nutraceuticals. The present study was designed to assess the possible reproductive toxicity of acrylamide in adult male Swiss albino rats. Also, the work was extended to investigate the potential protective effects of two nutraceuticals namely; thymoquinone (TQ) and capsaicin against acrylamide-induced reproductive toxicity. Sixty male albino rats were allotted into six groups. Group 1: Rats received free tap water and served as control group. Group 2: Rats received acrylamide in a daily dose and served as the model. Group 3: Rats were administered TQ twice weekly. Group 4: Rats were administered capsaicin once daily. Group 5: Rats challenged with acrylamide were administered TQ twice weekly. Group 6: Rats challenged with acrylamide were administered capsaicin once daily. A murine model of acrylamide testicular toxicity was reproduced and was characterized biochemically, morphologically and histologically. Acrylamide increased oxidative stress, expression of testicular NF-κB/p65, in addition down regulated the expression of occludin that may further account for its testicular toxicity. Both nutraceuticals; TQ and capsaicin have proven more or less efficacy in ameliorating all the toxic insults exerted by acrylamide in the current reproductive toxicity model.

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Section: Introductionmentioning

confidence: 99%

Effects of Thymoquinone or Capsaicin against Acrylamide-Induced Testicular Failure in Rats: Impact Oxidative Stress, NF-Κb/P65, and Occludin

Hasan¹,

haleem²,

Arafa³

2020

Preprint

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“…[1][2][3][4][5] Topical capsaicin acts in the skin to reduce pain and diminish cutaneous hypersensitivity by a process best described as the "defunctionalization" of nociceptor fibers. Defunctionalization can be achieved by repeated applications of capsaicin, which can render a loss of responsiveness in patients to a wide range of noxious stimuli.…”

Section: Introductionmentioning

confidence: 99%

Capsaicin-loaded nanolipoidal carriers for topical application: design, characterization, and in vitro/in vivo evaluation

Wang¹,

Gao²,

Niu³

et al. 2017

IJN

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Capsaicin has been used in clinical applications for the treatment of pain disorders and inflammatory diseases. Given the strong pungency and high oil/water partition coefficient of capsaicin, capsaicin-loaded nanolipoidal carriers (NLCs) were designed to increase permeation and achieve the analgesic, anti-inflammatory effect with lower skin irritation. Capsaicin-loaded NLCs were prepared and later optimized by the Box–Behnken design. The physicochemical characterizations, morphology, and encapsulation of the capsaicin-loaded NLCs were subsequently confirmed. Capsaicin-loaded NLCs and capsaicin-loaded NLCs gel exhibited sustained release and no cytotoxicity properties. Also, they could significantly enhance the penetration amount, permeation flux, and skin retention amounts of capsaicin due to the application of NLCs. To study the topical permeation mechanism of capsaicin, 3,3′-dioctadecyloxacarbocyanine perchlorate (Dio) was used as a fluorescent dye. Dio-loaded NLCs and Dio-loaded NLCs gel could effectively deliver Dio up to a skin depth of 260 and 210 μm, respectively, primarily through the appendage route on the basis of version skin sections compared with Dio solution, which only delivered Dio up to 150 μm. In vivo therapeutic experiments demonstrated that capsaicin-loaded NLCs and capsaicin-loaded NLCs gel could improve the pain threshold in a dose-dependent manner and inhibit inflammation, primarily by reducing the prostaglandin E2 levels in the tissue compared with capsaicin cream and capsaicin solution. Meanwhile, skin irritation was reduced, indicating that application of NLCs could decrease the irritation caused by capsaicin. Overall, NLCs may be a potential carrier for topical delivery of capsaicin for useful pain and inflammation therapy.

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“…Capsaicin topically is being tried and showing promising results in patients with diabetic neuropathic pain. [17] In this study 5 days after CCI, rats showed a relatively higher degree of allodynia and hyperalgesia against mechanical and thermal stimuli. The role of anticonvulsant drugs in the treatment of neuropathic pain is evolving and has been clearly demonstrated with gabapentin and carbamazepine.…”

Section: Discussionmentioning

confidence: 96%

Comparing the efficacy of carbamazepine, gabapentin and lamotrigine in chronic constriction injury model of neuropathic pain in rats

Chogtu

Bairy

Himabindu

et al. 2013

Int J Nutr Pharmacol Neurol Dis

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Context: Anti-epileptics are used in the treatment of neuropathic pain. Newer anti-epileptics with improved safety profile are being used in neuropathic pain. The animal models of neuropathic pain have helped to find newer drugs for this condition. As the efficacy of these drugs is modest, there is always a need to compare the efficacy of newer anti-epileptics with conventional drugs in this condition. Aims: The aim of this study was to compare the efficacy of anti-epileptics in neuropathic pain induced by chronic constriction injury. Settings and Design: It was a randomised, prospective study. Materials and Methods: The rats were divided into four groups. The first three groups were administered each of carbamazepine, gabapentin and lamotrigine respectively and the fourth group acted as control. Assessment was started on day five of surgery by hot plate method and Randall Selitto test. Statistical Analysis Used: Statistical analysis was done by one way analysis of variance followed by posthoc test. Results: In mechanical allodynia rats treated with lamotrigine and gabapentin (P = 0.001) showed a significant increase in mechanical threshold whereas in thermal hyperalgesia, it was the carbamazepine (P = 0.027) which was superior to other two drugs. Conclusions: Lamotrigine and gabapentin are efficacious in mechanical allodynia whereas carbamazepine is superior in thermal hyperalgesia. This shows that effect of drugs vary in different behavioral tests. So, the choice of treatment in different types of neuropathic pain can vary.

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Capsaicin: A promising therapy - A critical reappraisal

Cited by 12 publications

References 46 publications

Effects of Thymoquinone or Capsaicin against Acrylamide-Induced Testicular Failure in Rats: Impact Oxidative Stress, NF-Κb/P65, and Occludin

Effects of Thymoquinone or Capsaicin against Acrylamide-Induced Testicular Failure in Rats: Impact Oxidative Stress, NF-Κb/P65, and Occludin

Capsaicin-loaded nanolipoidal carriers for topical application: design, characterization, and in vitro/in vivo evaluation

Comparing the efficacy of carbamazepine, gabapentin and lamotrigine in chronic constriction injury model of neuropathic pain in rats

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