The Effect of Vitamin D on Expression of TGF β1 in Ovary

Çördük, Nergül; Abban, Gülçin; Yildirim, Basak; Sarioglu-Buke, Akile

doi:10.1055/s-0032-1314858

Cited by 10 publications

(12 citation statements)

References 18 publications

(23 reference statements)

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“…TGFb1 could be a potential serum marker for invasiveness of prolactinomas -the simultaneous determination of TGFb1 and PRL levels could improve the noninvasive assessment of prolactinoma behaviour [105]. TGFb1 is thought to have important roles in several stages of folliculogenesis [106]. Maurya et al's [107] study demonstrates the importance of the liberation of biologically active TGFb1 from its latent complex during embryo implantation period and its regulation by oestradiol [107].…”

Section: Tgfb1 In Pathologymentioning

confidence: 99%

Transforming growth factor beta1 (TGFbeta1) in physiology and pathology

Kajdaniuk¹,

Marek²,

Borgiel−Marek³

et al. 2013

Endokrynologia Polska

150

118

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This review describes precisely the consequence of TGFb1 prevalence in the organism, and its significant influence on physiological and pathophysiological processes. Organ and tissue distinctiveness hinder unambiguous characterisation of the cytokine. However, there are constant functions of TGFb1 inducing no controversy: it participates in foetal development, control of cell growth and differentiation, induces fibrosis and scar formation (the process of 'wound healing'), causes the suppression of immune response, is involved in angiogenesis, the development of tumours, and inflammatory processes. Thus, TGFb1 is a multifunctional cytokine. There are three fundamental directions of its activities: I. TGFb1 regulates cell proliferation, growth, differentiation and cells movement. II. TGFb1 has immunomodulatory effects. III. TGFb1 has profibrogenic effects. TGFb1 action can be local and systemic. This review describes TGFb1 in pathology: colitis ulcerosa, Crohn's disease, coeliac disease, diabetic nephropathy, diabetic retinopathy and diabetic foot, pulmonary hypertension, and Alzheimer's disease. TGFb1 and its receptors are also of interest to endocrinologists. Lack of TGFb1-dependent growth control may result in oncogenesis: papillary, follicular and anaplastic thyroid cancers, prostate, breast and uterine cervical cancer, oesophagus, gastric, colorectal and liver cancers, NSCLC, and malignant melanoma. Excessive TGFb1 activity is an integral part of the fibrotic processes occurring in the response to injury. An increased TGFb1 expression has been observed in patients with pulmonary, kidney, and liver fibrosis. In chronic hepatitis, the prolonged stimulation of hepatic stellate cells being the result of chronic damage to hepatocytes results in the release of profibrogenic abundant factors such as TGFb1 and leads to the development of liver cirrhosis. The results of experimental procedures and treatment known as anti-TGFb1 strategy acting against the fibrosis in various tissues leads to hope regarding the use of anti-TGFb1 strategy in clinical practice. StreszczenieW artykule poglądowym szczegółowo opisano konsekwencje rozpowszechnienia TGFb1 w organizmie oraz jego wpływ na szereg procesów fizjologicznych i patofizjologicznych. Istotne odrębności narządowe i tkankowe utrudniają jednoznaczną charakterystykę tej cytokiny. Istnieją jednak stałe funkcje TGFb1 nie wzbudzające kontrowersji: uczestniczy w rozwoju płodu, regulacji wzrostu i różnicowa-nia komórek, indukuje proces włóknienia i bliznowacenia (proces "gojenia rany"), powoduje hamowanie odpowiedzi immunologicznej, uczestniczy w angiogenezie, w rozwoju nowotworów, w procesach zapalnych -jest więc cytokiną wieloczynnościową. Można wyróżnić trzy fundamentalne kierunki jego działania: I -TGFb1 reguluje proliferację, wzrost, różnicowanie i przemieszczanie komórek; II -TGFb1 wykazuje działanie immunomodulujące; III -TGFb1 wykazuje działanie profibrogenne. Działanie TGFb1 może mieć charakter miejscowy i systemowy. Opisano udział TGFb1 w stanach patologicznyc...

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Section: Tgfb1 In Pathologymentioning

confidence: 99%

Transforming growth factor beta1 (TGFbeta1) in physiology and pathology

Kajdaniuk¹,

Marek²,

Borgiel−Marek³

et al. 2013

Endokrynologia Polska

150

118

View full text Add to dashboard Cite

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“…tarafından yapılan çalışmada, D vitamininin sıçan yumurtalıklarında da TGF-β1 seviyelerini azalttığı saptanmıştır. 22 Sonuçlar birlikte ele alındığında, D vitamininin PKOS tedavisindeki olumlu etkileri, yolaklarından biri D vitamininin TGF-β1 üzerindeki etkileriyle açıklanabilir.…”

Section: Poli̇ki̇sti̇k Over Sendromunda D Vi̇tami̇ni̇ Eksi̇kli̇ği̇unclassified

“…25 İnsülin direnci ile ilişkili klinik sendromlar arasında Tip 2 diyabet, dislipidemi, metabolik sendrom, kardiyovasküler hastalık, esansiyel hipertansiyon, PKOS, alkolsüz yağlı karaciğer hastalığı, belirli kanser ve uyku apnesi türleri de bulunmaktadır. 22 İnsülin direnci, obezitenin derecesine bağlı olarak genel popülasyonun %10 ile %25'ini etkilemektedir. 26 Mevcut kanıtlar, insülin direncinin PKOS patogenezinde merkezi bir role sahip olduğunu ve hem metabolik hem de reprodüktif bozukluklara (hem uterus hem de ovaryuma ait bozukluklar) katkıda bulunduğunu ileri sürmektedir.…”

Section: Poli̇ki̇sti̇k Over Sendromu Ve İnsüli̇n Di̇renci̇unclassified

Complex Relationship: Vitamin D, Insulin Resistance and Polycystic Ovary Syndrome

Kenger¹,

Ozlu²,

Gürdoğan³

et al. 2020

Turkiye Klinikleri J Intern Med

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ÖZET Polikistik over sendromu (PKOS); menstrüel düzensizlik, yükselmiş androjen seviyeleri ve polikistik görünümlü overler gibi özellikleri ile üreme çağındaki kadınlarda en sık görülen endokrinopatidir. Kalıtım, obezite, diyabet hastalığı PKOS için başlıca risk faktörlerindendir. Bununla birlikte, mevcut kanıtlar insülin direncinin PKOS patogenezinde merkezi bir role sahip olduğunu ve altta yatan metabolik anormallikleri şiddetlendiren önemli bir faktör olarak öne çıktığını göstermektedir. Gözlemsel çalışmalar D vitamini eksikliğinin de PKOS gelişiminde rol oynayabileceğini düşündürmektedir. PKOS'lu kadınlarda D vitamini eksikliği yaygın görülen bir sorundur. PKOS'lu kadınların %67-85'inin ortalama 25-hidroksi vitamin D (25OHD) düzeyleri 20 ng/mL'nin altındadır. D vitamini eksikliği özellikle obezite, hiperandrojenizm, üreme fonksiyonlarında bozukluk durumlarını daha da ağırlaştırarak PKOS gelişimine zemin hazırlayabilmektedir. Bununla birlikte yapılan çalışmalar D vitamini eksikliğinin, PKOS patogenezinde başlıca rol oynayan insülin direncinin gelişiminde önemli bir rol oynadığını ortaya çıkarmıştır. Yakın geçmişte PKOS tedavisinde D vitamini takviyesinin etkilerini değerlendiren bazı randomize kontrollü çalışmalar dâhil olmak üzere yapılan çeşitli çalışmaların sonuçları ise değişkenlik göstermektedir. Vitamin D takviyesinin PKOS yönetimi için yararlı olabileceği düşünülse de PKOS'lu kadınlarda D vitamini desteğinin insülin direnci ve diğer semptomlar üzerindeki etkileri ve bu etkilerin hangi yolaklarla sağlandığı konuları hâlâ belirsizliğini korumaktadır. Bu çalışmada, D vitamininin PKOS ve insülin direnci patogenezindeki olası etkilerini ve PKOS tedavisindeki rolünü ortaya koymak amaçlanmıştır. Anah tar Ke li me ler: D vitamini eksikliği; insülin direnci;polikistik over sendromu ABS TRACT Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age with features such as menstrual irregularity, elevated androgen levels and polycystic ovaries. Family history, obesity, diabetes are the main risk factors for PCOS. However, current evidence suggests that insulin resistance plays a central role in the pathogenesis of PCOS and appears to be an important factor that compounds underlying metabolic abnormalities. Observational studies suggest that vitamin D deficiency may also play a role in the development of PCOS. Vitamin D deficiency is a common problem in women with PCOS. 67-85% of women with PCOS have 25-hydroxy vitamin D (25OHD) levels below 20 ng/mL. Vitamin D deficiency may aggravate the conditions of obesity, hyperandrogenism and reproductive functions, and may pave the way for the development of PCOS. However, studies have shown that vitamin D deficiency plays an important role in the development of insulin resistance, which plays a major role in PCOS pathogenesis. The results of several recent studies, including some randomized controlled trials evaluating the effects of vitamin D supplementation in PCOS treatment are variable. Although vitamin D supplementation is thought ...

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“…The most important in intraovarian factors include bone morphogenetic proteins (BMPs) 6, 7 and 15 (BMP6, BMP 7 and BMP15), ovarian somatic cells and transforming growth factor-beta (TGFB) expressed specifically by oocytes during the folliculogenesis phase (TGFB1 and TGFB2) are members of the superfamily (Knight and Glister 2006, Otsuka 2010). The cited genes regulate ovarian follicular development at the molecular level in addition to affecting fertility (Corduk et al 2012, Nagashima et al 2011, Paradis et al 2009. Furthermore, the growth differentiation factor 9 (GDF9) gene expression is important for both humans and animals as regards oocyte competence and fertility (Barros et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Holştayn Sığırlarında Foliküler ve Luteal Fazdaki Ovaryum Dokularında İntraovarian Genlerin Ekspresyon Profili

Özdemir¹,

Çomaklı²,

Arslan³

2018

Kocatepe Veterinary Journal

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The aim of the present study is to determine comparatively expression levels of the BMP15, TGFB1, TGFB2 and GDF9 genes in the preovulatory follicle and corpus luteum tissue of Holstein cattle. For this purpose, primarily the tissues were examined by immunohistochemical staining. Later on, follicular fluid was analyzed by ELISA test and estradiol and progesterone levels were determined. Finally, expression levels of the related genes were determined between the groups by qRT-PCR. Immunohistochemical staining revealed that estrogen receptor alpha and progesterone receptor immunoreactivities were intensely present in preovulatory follicles, estrogen alpha receptor immunoreactivity was very slight and progesterone receptors were similar to positivity in preovulatory follicles in corpus luteum. Furthermore, estradiol level was high in preovulatory follicles and progesterone level was high in corpus luteum. The levels of mRNA transcripts of the TGFB1 and TGFB2 genes in the preovulatory follicles were statistically higher than the corpus luteum (p<0.01, p<0.05, respectively), but there was no statistically significant difference between the groups in the mRNA transcript levels of the BMP15 and GDF9 genes (p>0.05). As a result, it is thought that differential expression of intraovarian genes may be associated with differences in follicular dynamics and gene expression levels within the cell population of ovarian tissue, so this situation may result in follicular and luteal phase.

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The Effect of Vitamin D on Expression of TGF β1 in Ovary

Cited by 10 publications

References 18 publications

Transforming growth factor beta1 (TGFbeta1) in physiology and pathology

Transforming growth factor beta1 (TGFbeta1) in physiology and pathology

Complex Relationship: Vitamin D, Insulin Resistance and Polycystic Ovary Syndrome

Holştayn Sığırlarında Foliküler ve Luteal Fazdaki Ovaryum Dokularında İntraovarian Genlerin Ekspresyon Profili

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